Results 101 to 110 of about 788,774 (301)
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
A Time-domain Study of Repeat and Nonrepeat Fast Radio Bursts
The Astrophysical JournalFast radio bursts (FRBs) are extremely energetic radio transients, typically classified as repeat or nonrepeat, but their origins remain uncertain. In this work, we focus on the timing characteristics of the pulses in 536 FRBs observed by CHIME with ...
Zheng-Huo Jiang +6 more
doaj +1 more source
Transient difference solutions of the inhomogeneous wave equation: Simulation of the Green's function [PDF]
A time-dependent finite difference formulation to the inhomogeneous wave equation is derived for plane wave propagation with harmonic noise sources. The difference equation and boundary conditions are developed along with the techniques to simulate the ...
Baumeiste, K. J.
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
The Astrophysical JournalFast radio bursts (FRBs) have emerged as one of the most dynamic areas of research in astronomy and cosmology. Despite increasing number of FRBs having been reported, the exact origin of FRBs remains elusive.
Huan Zhou, Zhengxiang Li, Zong-Hong Zhu
doaj +1 more source
Source separation techniques for characterising cosmic ray transients from neutron monitor networks [PDF]
, 2008 Thierry Dudok de Wit +2 more
openalex +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
A Catalog of Local Universe Fast Radio Bursts from CHIME/FRB and the KKO
The Astrophysical Journal Supplement SeriesWe present the first catalog of fast radio burst (FRB) host galaxies from CHIME/FRB Outriggers, selected uniformly in the radio and the optical by localizing 81 new bursts to 2″ × ∼ 60″ accuracy using CHIME and the k’niʔatn k’l ⌣ stk’masqt Outrigger ...
The CHIME/FRB Collaboration +64 more
doaj +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source