Results 61 to 70 of about 788,774 (301)

A powerful bursting radio source towards the Galactic Centre

, 2005
Transient astronomical sources are typically powered by compact objects and usually signify highly explosive or dynamic events. While radio astronomy has an impressive record of obtaining high time resolution observations, usually it is achieved in quite
ACS Readhead, AD Gray, AG Lyne, AJ Burgasser, AP Marscher, Craig B. Markwardt, DB Melrose, E Berger, E Berger, F Yusef-Zadeh, Farhad Yusef-Zadeh, G Bruggmann, GA Dulk, H Bradt, HA Mayer-Hasselwander, J-H Zhao, M Guedel, ME Nord, Namir E. Kassim, Paul S. Ray, RM Cutri, RP Fender, Scott D. Hyman, SD Hyman, SD Hyman, T. Joseph W. Lazio, TH Hankins, TJW Lazio, TS Bastian, TS Bastian, W Reich, WM Farrell   +31 more
core   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

The Radio Counterpart to the Fast X-Ray Transient EP240414a

The Astrophysical Journal
Despite being operational for only a short time, the Einstein Probe mission, with its large field of view and rapid localization capabilities, has already significantly advanced the study of rapid variability in the soft X-ray sky.
Joe S. Bright, Francesco Carotenuto, Rob Fender, Carmen Choza, Andrew Mummery, Peter G. Jonker, Stephen J. Smartt, David R. DeBoer, Wael Farah, James Matthews, Alexander W. Pollak, Lauren Rhodes, Andrew Siemion   +12 more
doaj   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

Molecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima, Yuko Takami, Ken Kawabe, Kazuhiro Tanabe, Chihiro Hayashi, Mikio Mikami, Tetsuya Kusumoto   +6 more
wiley   +1 more source

The Nature of Optical Afterglows without Gamma-Ray Bursts: Identification of AT2023lcr and Multiwavelength Modeling

The Astrophysical Journal
In the past few years, the improved sensitivity and cadence of wide-field optical surveys have enabled the discovery of several afterglows without associated detected gamma-ray bursts (GRBs).
Maggie L. Li, Anna Y. Q. Ho, Geoffrey Ryan, Daniel A. Perley, Gavin P. Lamb, Nayana A.J., Igor Andreoni, G. C. Anupama, Eric C. Bellm, Edo Berger, Joshua S. Bloom, Eric Burns, Ilaria Caiazzo, Poonam Chandra, Michael W. Coughlin, Kareem El-Badry, Matthew J. Graham, Mansi Kasliwal, Garrett K. Keating, S. R. Kulkarni, Harsh Kumar, Frank J. Masci, Richard A. Perley, Josiah Purdum, Ramprasad Rao, Antonio C. Rodriguez, Ben Rusholme, Nikhil Sarin, Jesper Sollerman, Gokul P. Srinivasaragavan, Vishwajeet Swain, Zachary Vanderbosch   +31 more
doaj   +1 more source

Swift/BAT and MAXI/GSC Broadband Transient Monitor

, 2015
We present the newly developed broadband transient monitor using the Swift Burst Alert Telescope (BAT) and the MAXI Gas Slit Camera (GSC) data. Our broadband transient monitor monitors high energy transient sources from 2 keV to 200 keV in seven energy ...
Arimoto, Makoto, Barthelmy, Scott D., Kawai, Nobuyuki, Krimm, Hans A., Mihara, Tatehiro, Nakahira, Satoshi, Oda, Ryoma, Sakamoto, Takanori, Serino, Motoko, Yoshida, Atsumasa   +9 more
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Delayed X-Ray Brightening Accompanied by Variable Ionized Absorption Following a Tidal Disruption Event

The Astrophysical Journal
Supermassive black holes can experience super-Eddington peak mass fallback rates following the tidal disruption of a star. The theoretical expectation is that part of the infalling material is expelled by means of an accretion disk wind, whose ...
T. Wevers, M. Guolo, D. R. Pasham, E. R. Coughlin, F. Tombesi, Y. Yao, S. Gezari   +6 more
doaj   +1 more source

Swift J1644+57: An Ultra-Luminous X-ray Event

, 2012
The photon spectral energy distribution of the powerful transient Sw J1644+57 resembles those of the brightest Ultra-Luminous X-ray sources (ULXs).
Goodman, Kompane'ets, Madau, Nayakshin, Nayakshin, Phinney, Ramirez-Ruiz, Ross, Shakura, Socrates, Socrates, Socrates, Sunyaev, Thompson   +13 more
core   +1 more source