Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian +10 more
wiley +1 more source
Follow the Mass—A Concordance Picture of Tidal Disruption Events
The Astrophysical JournalThree recent global simulations of tidal disruption events (TDEs) have produced, using different numerical techniques and parameters, very similar pictures of their dynamics.
Julian Krolik, Tsvi Piran, Taeho Ryu
doaj +1 more source
Molecular Oncology, EarlyView.We evaluated circulating tumor DNA (ctDNA) detection in advanced pancreatic cancer using DNA methylation, cell‐free DNA fragment lengths, and 5′ end motifs. Machine learning models were trained to estimate ctDNA levels from each feature and their combination.
Morten Lapin +10 more
wiley +1 more source
Low-frequency, Wideband Study of an Active Repeater, FRB 20240114A, with the GMRT
The Astrophysical JournalWe report the detection of 167 bursts from an active repeater, FRB 20240114A, using the upgraded Giant Metrewave Radio Telescope. The observations were carried out over a frequency range of 300–750 MHz, and on four different dates over a period of 6 ...
U. Panda +4 more
doaj +1 more source
Dual-action benefits: global (action-inherent) and local (transient) sources of action prepotency underlying inhibition failures in multiple action control. [PDF]
Psychol Res, 2023 Kürten J +3 more
europepmc +1 more source
Convergence characteristics and acceleration of the transient fixed source equation solved by Monte Carlo method [PDF]
, 2023 Xiaoyu Guo, Guanbo Wang, Kan Wang
openalex +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Bright Bursts with Submillisecond Structures of FRB 20230607A in a Highly Magnetized Environment
The Astrophysical JournalWe report the observations of a repeating FRB 20230607A for 15.6 hr spanning 16 months using the Five-hundred-meter Aperture Spherical Radio Telescope with the detection of 565 bursts.
DeJiang Zhou +21 more
doaj +1 more source
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
CSS 161010: A Luminous Fast Blue Optical Transient with Broad Blueshifted Hydrogen Lines
The Astrophysical JournalWe present ultraviolet, optical, and near-infrared photometric and optical spectroscopic observations of the luminous fast blue optical transient (LFBOT) CSS 161010:045834–081803 (CSS 161010).
Claudia P. Gutiérrez +40 more
doaj +1 more source