Results 91 to 100 of about 548,529 (284)

Transient model analysis of gas flow behavior for a multi-fractured horizontal well incorporating stress-sensitive permeability

Journal of Petroleum Exploration and Production Technology, 2018
The assumption of constant reservoir permeability is not strictly applicable to reservoirs where rock properties undergo changes, such as stress-sensitive porous media.
Li-Na Cao, Li-Ze Lu, Xiao-Ping Li, He-Hua Wang, Wei He, Bing Xu, Yong Deng, Li-Ping Jiang   +7 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Establishment of an Efficient Protoplast Isolation and Transfection Method for Eucommia ulmoides Oliver

Frontiers in Bioscience-Landmark
Background: Eucommia ulmoides Oliver is a unique high-quality natural rubber tree species and rare medicinal tree species in China. The rapid characterization of E.
Bin Hu, Mingyang Dong, Ruonan Liu, Wen Shan, Yi Wang, Yang Ding, Jingyi Peng, Luyang Meng, Chaoyong Wang, Qiang Zhou   +9 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

An Effective Agrobacterium-Mediated Transient Transformation System for Studying the Lead-Tolerance Genes in Hydrangea

Horticulturae
Soil lead (Pb) contamination is a severe environmental issue. Hydrangea, with high ornamental value, shows strong tolerance to the heavy metal Pb. Discovery of the gene(s) determining Pb resistance has been hindered by the lack of a stabilized and ...
Rong Cong, Liang Shi, Bing Zhao
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Deterministically driven random walks in a random environment on Z [PDF]

, 2013
We introduce the concept of a deterministic walk in a deterministic environment on a countable state space (DWDE). For the deterministic walk in a fixed environment we establish properties analogous to those found in Markov chain theory, but for systems ...
Little, Colin M. W.
core  

Analysis of Transient Actions Influence in Power Transformer

Advances in Electrical and Electronic Engineering, 2011
This article is focused on the theory of unacceptable effect on transformer winding, mainly the overvoltages and the mechanical forces. In the next part of the article is described the measurement of selfdischarging voltage frequency dependence on transformer. The second measurement shows one of the possible type of SFRA method. The measurement results
Jurcik, Jozef, Gutten, Miroslav, Korenčiak, Daniel   +2 more
openaire   +3 more sources