Results 71 to 80 of about 2,352,765 (289)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Elucidating the Molecular Mechanisms of Physiological Fruit Abscission in Actinidia arguta Through Comparative Transcriptomics and Transient Genetic Transformation

Plants
Actinidia arguta (A. arguta) is valued for its nutritional richness, but physiological fruit abscission severely limits production efficiency in elite cultivars. To unravel the molecular basis of this process, we compared two cultivars: abscission-prone ‘
Pengqiang Yuan, Yanli Wang, Yining Sun, Guoliang Liu, Hongyan Qin, Shutian Fan, Yiping Yan, Bowei Sun, Wenpeng Lu   +8 more
doaj   +1 more source

Transient model analysis of gas flow behavior for a multi-fractured horizontal well incorporating stress-sensitive permeability

Journal of Petroleum Exploration and Production Technology, 2018
The assumption of constant reservoir permeability is not strictly applicable to reservoirs where rock properties undergo changes, such as stress-sensitive porous media.
Li-Na Cao, Li-Ze Lu, Xiao-Ping Li, He-Hua Wang, Wei He, Bing Xu, Yong Deng, Li-Ping Jiang   +7 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Phase-mode transformation matrix application for transmission line and electromagnetic transient analyses

, 2011
Frequency-dependent transmission line models can be developed in phase domain or in mode domain. Associated to these transmission line models, time domain or frequency domain can be used for electromagnetic transient analysis solutions.
Filho, José Pissolato [UNESP], Do Prado, Afonso José [UNESP], Kurokawa, Sérgio [UNESP], Bovolato, Luiz Fernando [UNESP], Da Costa, Eduardo Coelho Marques [UNESP]   +4 more
core  

Establishment of an Efficient Protoplast Isolation and Transfection Method for Eucommia ulmoides Oliver

Frontiers in Bioscience-Landmark
Background: Eucommia ulmoides Oliver is a unique high-quality natural rubber tree species and rare medicinal tree species in China. The rapid characterization of E.
Bin Hu, Mingyang Dong, Ruonan Liu, Wen Shan, Yi Wang, Yang Ding, Jingyi Peng, Luyang Meng, Chaoyong Wang, Qiang Zhou   +9 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Induction of Embryogenic Callus, Protoplast Isolation, and PEG-Mediated Transformation Protocols in Eucommia ulmoides

Plants
Eucommia ulmoides, a tree species native to China, holds considerable medicinal, ecological, and industrial importance. However, the absence of an efficient and stable genetic transformation system poses significant challenges to gene function studies ...
Hongrun Zhou, Zibo Zhou, Jiangyuan Zhang, Haoran Kan, Mengqi Yin, Han Zhang, Luyao Wang, Jie Zhao, Jing Ye   +8 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source