Results 111 to 120 of about 75,518 (268)

Orbital Decay of the Ultra-hot Jupiter TOI-2109b: Tidal Constraints and Transit-timing Analysis

The Astrophysical Journal
TOI-2109b is the ultra-hot Jupiter with the shortest orbital period (∼16 hr) yet discovered. At this close distance, strong tidal interactions can produce a significant exchange of angular momentum with the star.
Jaime A. Alvarado-Montes, Mario Sucerquia, Jorge I. Zuluaga, Christian Schwab   +3 more
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

The TESS-Keck Survey. XVII. Precise Mass Measurements in a Young, High-multiplicity Transiting Planet System Using Radial Velocities and Transit Timing Variations

The Astronomical Journal
We present a radial velocity (RV) analysis of TOI-1136, a bright Transiting Exoplanet Survey Satellite (TESS) system with six confirmed transiting planets, and a seventh single-transiting planet candidate.
Corey Beard, Paul Robertson, Fei Dai, Rae Holcomb, Jack Lubin, Joseph M. Akana Murphy, Natalie M. Batalha, Sarah Blunt, Ian Crossfield, Courtney Dressing, Benjamin Fulton, Andrew W. Howard, Dan Huber, Howard Isaacson, Stephen R. Kane, Grzegorz Nowak, Erik A Petigura, Arpita Roy, Ryan A. Rubenzahl, Lauren M. Weiss, Rafael Barrena, Aida Behmard, Casey L. Brinkman, Ilaria Carleo, Ashley Chontos, Paul A. Dalba, Tara Fetherolf, Steven Giacalone, Michelle L. Hill, Kiyoe Kawauchi, Judith Korth, Rafael Luque, Mason G. MacDougall, Andrew W. Mayo, Teo Močnik, Giuseppe Morello, Felipe Murgas, Jaume Orell-Miquel, Enric Palle, Alex S. Polanski, Malena Rice, Nicholas Scarsdale, Dakotah Tyler, Judah Van Zandt   +43 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

A Fourth Planet in the Kepler-51 System Revealed by Transit Timing Variations

The Astronomical Journal
Kepler-51 is a ≲1 Gyr old Sun-like star hosting three transiting planets with radii ≈6–9 R _⊕ and orbital periods ≈45–130 days. Transit timing variations (TTVs) measured with past Kepler and Hubble Space Telescope (HST) observations have been ...
Kento Masuda, Jessica E. Libby-Roberts, John H. Livingston, Kevin B. Stevenson, Peter Gao, Shreyas Vissapragada, Guangwei Fu, Te Han, Michael Greklek-McKeon, Suvrath Mahadevan, Eric Agol, Aaron Bello-Arufe, Zachory Berta-Thompson, Caleb I. Cañas, Yayaati Chachan, Leslie Hebb, Renyu Hu, Yui Kawashima, Heather A. Knutson, Caroline V. Morley, Catriona A. Murray, Kazumasa Ohno, Armen Tokadjian, Xi Zhang, Luis Welbanks, Matthew C. Nixon, Richard Freedman, Norio Narita, Akihiko Fukui, Jerome P. de Leon, Mayuko Mori, Enric Palle, Felipe Murgas, Hannu Parviainen, Emma Esparza-Borges, Daniel Jontof-Hutter, Karen A. Collins, Paul Benni, Khalid Barkaoui, Francisco J. Pozuelos, Michaël Gillon, Emmanuël Jehin, Zouhair Benkhaldoun, Suzanne Hawley, Andrea S. J. Lin, Guđmundur Stefánsson, Allyson Bieryla, Mesut Yilmaz, Hakan Volkan Senavci, Eric Girardin, Giuseppe Marino, Gavin Wang   +51 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Giant Outer Transiting Exoplanet Mass (GOT ‘EM) Survey. IV. Long-term Doppler Spectroscopy for 11 Stars Thought to Host Cool Giant Exoplanets

The Astrophysical Journal Supplement Series
Discovering and characterizing exoplanets at the outer edge of the transit method’s sensitivity has proven challenging owing to geometric biases and the practical difficulties associated with acquiring long observational baselines.
Paul A. Dalba, Stephen R. Kane, Howard Isaacson, Benjamin Fulton, Andrew W. Howard, Edward W. Schwieterman, Daniel P. Thorngren, Jonathan Fortney, Noah Vowell, Corey Beard, Sarah Blunt, Casey L. Brinkman, Ashley Chontos, Fei Dai, Steven Giacalone, Michelle L. Hill, Molly Kosiarek, Jack Lubin, Andrew W. Mayo, Teo Močnik, Joseph M. Akana Murphy, Erik A. Petigura, Malena Rice, Ryan A. Rubenzahl, Judah Van Zandt, Lauren M. Weiss, Diana Dragomir, David Kipping, Matthew J. Payne, Arpita Roy, Alex Teachey, Steven Villanueva Jr.   +31 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Investigating the Atmospheric Mass Loss of the Kepler-105 Planets Straddling the Radius Gap

The Astronomical Journal
An intriguing pattern among exoplanets is the lack of detected planets between approximately 1.5 R _⊕ and 2.0 R _⊕ . One proposed explanation for this “radius gap” is the photoevaporation of planetary atmospheres, a theory that can be tested by studying ...
Aaron Householder, Lauren M. Weiss, James E. Owen, Howard Isaacson, Andrew W. Howard, Daniel Fabrycky, Leslie A. Rogers, Hilke E. Schlichting, Benjamin J. Fulton, Erik A. Petigura, Steven Giacalone, Joseph M. Akana Murphy, Corey Beard, Ashley Chontos, Fei Dai, Judah Van Zandt, Jack Lubin, Malena Rice, Alex S. Polanski, Paul Dalba, Sarah Blunt, Emma V. Turtelboom, Ryan Rubenzahl, Casey Brinkman   +23 more
doaj   +1 more source

Transcriptional regulation of neuropeptide receptors underlies context‐dependent adaptation in Drosophila melanogaster

FEBS Open Bio, EarlyView.
Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu, Yanan Wei, Zekun Wu, Tianmu Zhang, DoHoon Lee, Hadi Najafi, Woo Jae Kim   +6 more
wiley   +1 more source