Results 51 to 60 of about 5,805 (230)
Updated Masses for the Gas Giants in the Eight-planet Kepler-90 System Via Transit-timing Variation and Radial Velocity Observations
The Astronomical JournalThe eight-planet Kepler-90 system exhibits the greatest multiplicity of planets found to date. All eight planets are transiting and were discovered in photometry from the NASA Kepler primary mission. The two outermost planets, g ( P _g = 211 days) and h David E. Shaw, Lauren M. Weiss, Eric Agol, Karen A. Collins, Khalid Barkaoui, Cristilyn N. Watkins, Richard P. Schwarz, Howard M. Relles, Chris Stockdale, John F. Kielkopf, Fabian Rodriguez Frustaglia, Allyson Bieryla, Joao Gregorio, Owen Mitchem, Katherine Linnenkohl, Adam Popowicz, Norio Narita, Akihiko Fukui, Michaël Gillon, Ramotholo Sefako, Avi Shporer, Adam Lark, Amelie Heying, Isa Khan, Beibei Chen, Kylee Carden, Donald M. Terndrup, Robert Taylor, Dasha Crocker, Sarah Ballard, Daniel C. Fabrycky +30 moredoaj +1 more sourceHighly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors
Molecular Oncology, EarlyView.Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi +10 morewiley +1 more sourceDetailed Architecture of the L 98-59 System and Confirmation of a Fifth Planet in the Habitable Zone
The Astronomical JournalThe L 98-59 system, identified by TESS in 2019, features three transiting exoplanets in compact orbits of 2.253, 3.691, and 7.451 days around an M3V star, with an outer 12.83 day nontransiting planet confirmed in 2021 using ESPRESSO.Charles Cadieux, Alexandrine L’Heureux, Caroline Piaulet-Ghorayeb, René Doyon, Étienne Artigau, Neil J. Cook, Louis-Philippe Coulombe, Pierre-Alexis Roy, David Lafrenière, Pierrot Lamontagne, Michael Radica, Björn Benneke, Eva-Maria Ahrer, Drew Weisserman, Ryan Cloutier +14 moredoaj +1 more sourceA large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival
Molecular Oncology, EarlyView.There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas +20 morewiley +1 more sourceTOI-1408: Discovery and Photodynamical Modeling of a Small Inner Companion to a Hot Jupiter Revealed by Transit Timing Variations
The Astrophysical Journal LettersWe report the discovery and characterization of a small planet, TOI-1408 c, on a 2.2 day orbit located interior to a previously known hot Jupiter, TOI-1408 b ( P = 4.42 days, M = 1.86 ± 0.02 M _Jup , R = 2.4 ± 0.5 R _Jup ) that exhibits grazing transits. Judith Korth, Priyanka Chaturvedi, Hannu Parviainen, Ilaria Carleo, Michael Endl, Eike W. Guenther, Grzegorz Nowak, Carina M. Persson, Phillip J. MacQueen, Alexander J. Mustill, Juan Cabrera, William D. Cochran, Jorge Lillo-Box, David Hobbs, Felipe Murgas, Michael Greklek-McKeon, Hanna Kellermann, Guillaume Hébrard, Akihiko Fukui, Enric Pallé, Jon M. Jenkins, Joseph D. Twicken, Karen A. Collins, Samuel N. Quinn, Ján Šubjak, Paul G. Beck, Davide Gandolfi, Savita Mathur, Hans J. Deeg, David W. Latham, Simon Albrecht, David Barrado, Isabelle Boisse, Hervé Bouy, Xavier Delfosse, Olivier Demangeon, Rafael A. García, Artie P. Hatzes, Neda Heidari, Kai Ikuta, Petr Kabáth, Heather A. Knutson, John Livingston, Eder Martioli, María Morales-Calderón, Giuseppe Morello, Norio Narita, Jaume Orell-Miquel, Hanna L. M. Osborne, Dinil B. Palakkatharappil, Viktoria Pinter, Seth Redfield, Howard M. Relles, Richard P. Schwarz, Sara Seager, Avi Shporer, Marek Skarka, Gregor Srdoc, Monika Stangret, Luis Thomas, Vincent Van Eylen, Noriharu Watanabe, Joshua N. Winn +62 moredoaj +1 more sourceMultidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells
Molecular Oncology, EarlyView.Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher +11 morewiley +1 more sourceTOI-2015 b: A Warm Neptune with Transit Timing Variations Orbiting an Active Mid-type M Dwarf
The Astronomical JournalWe report the discovery of a close-in ( P _orb = 3.349 days) warm Neptune with clear transit timing variations (TTVs) orbiting the nearby ( d = 47.3 pc) active M4 star, TOI-2015.Sinclaire E. Jones, Guđmundur Stefánsson, Kento Masuda, Jessica E. Libby-Roberts, Cristilyn N. Gardner, Rae Holcomb, Corey Beard, Paul Robertson, Caleb I. Cañas, Suvrath Mahadevan, Shubham Kanodia, Andrea S. J. Lin, Henry A. Kobulnicky, Brock A. Parker, Chad F. Bender, William D. Cochran, Scott A. Diddams, Rachel B. Fernandes, Arvind F. Gupta, Samuel Halverson, Suzanne L. Hawley, Fred R. Hearty, Leslie Hebb, Adam Kowalski, Jack Lubin, Andrew Monson, Joe P. Ninan, Lawrence Ramsey, Arpita Roy, Christian Schwab, Ryan C. Terrien, John Wisniewski +31 moredoaj +1 more sourceEscape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells
Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk +11 morewiley +1 more sourceTESS Hunt for Young and Maturing Exoplanets (THYME). X. A Two-planet System in the 210 Myr MELANGE-5 Association
The Astronomical JournalYoung (Pa Chia Thao, Andrew W. Mann, Madyson G. Barber, Adam L. Kraus, Benjamin M. Tofflemire, Jonathan L. Bush, Mackenna L. Wood, Karen A. Collins, Andrew Vanderburg, Samuel N. Quinn, George Zhou, Elisabeth R. Newton, Carl Ziegler, Nicholas Law, Khalid Barkaoui, Francisco J. Pozuelos, Mathilde Timmermans, Michaël Gillon, Emmanuël Jehin, Richard P. Schwarz, Tianjun Gan, Avi Shporer, Keith Horne, Ramotholo Sefako, Olga Suarez, Djamel Mekarnia, Tristan Guillot, Lyu Abe, Amaury H. M. J. Triaud, Don J. Radford, Ana Isabel Lopez Murillo, George R. Ricker, Joshua N. Winn, Jon M. Jenkins, Luke G. Bouma, Michael Fausnaugh, Natalia M. Guerrero, Michelle Kunimoto +37 moredoaj +1 more sourceShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling
Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones +11 morewiley +1 more source
