Results 51 to 60 of about 19,159 (254)

Exoplanet Ephemerides Change Observations (ExoEcho). II. Transit Timing Variation Analysis of Brown Dwarfs around Solar-type Stars

open access: yesThe Astrophysical Journal
Transit timing variation (TTV) is a useful tool for studying the orbital properties of transiting objects. However, few TTV studies have been done on transiting brown dwarfs (BDs) around solar-type stars.
Wenqin Wang   +5 more
doaj   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

open access: yesFEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang   +2 more
wiley   +1 more source

A stepwise emergence of evolution in the RNA world

open access: yesFEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Validation of a Third Planet in the LHS 1678 System

open access: yesThe Astronomical Journal
The nearby LHS 1678 (TOI-696) system contains two confirmed planets and a wide-orbit, likely brown-dwarf companion, which orbit an M2 dwarf with a unique evolutionary history. The host star occupies a narrow “gap” in the Hertzsprung–Russell diagram lower
Michele L. Silverstein   +26 more
doaj   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

open access: yesFEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp   +5 more
wiley   +1 more source

Exoplanet Ephemerides Change Observations (ExoEcho). I. Transit Timing Analysis of 37 Exoplanets Using HST/WFC3 Data

open access: yesThe Astronomical Journal
The ExoEcho project is designed to study the photodynamics of exoplanets by leveraging high-precision transit timing data from ground- and space-based telescopes.
Xinyue Ma   +8 more
doaj   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

open access: yesFEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro   +2 more
wiley   +1 more source

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

open access: yesFEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche   +2 more
wiley   +1 more source

Doomed Worlds. I. No New Evidence for Orbital Decay in a Long-term Survey of 43 Ultrahot Jupiters

open access: yesThe Planetary Science Journal
Ultrahot Jupiters (UHJs) are likely doomed by tidal forces to undergo orbital decay and eventual disruption by their stars, but the timescale over which this process unfolds is unknown. We present results from a long-term project to monitor UHJ transits.
Elisabeth R. Adams   +10 more
doaj   +1 more source

Machine Learning Implementation on TTV Analysis using TTVFast

open access: yesJournal of Physics: Conference Series
Exoplanet research has undergone rapid development lately due to the increasing number of space telescopes and satellite surveys launched in recent years. Two missions with the most exoplanet discoveries using transit methods are Kepler and TESS missions.
M. I. Ikhsan   +2 more
semanticscholar   +1 more source

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