Results 71 to 80 of about 5,813 (219)

MicroRNA 196a contributes to the aggressiveness of esophageal adenocarcinoma through the MYC/TERT/NFκB axis

Molecular Oncology, EarlyView.
mir‐196a promotes Esophagus Adenocarcinoma aggressiveness. On one hand, mir‐196a targets the valosin‐containing protein (VCP) mRNA, causing the accumulation of c‐MYC protein that leads to high amounts of TERT. On the other hand, mir‐196a targets the inhibitor of NFκB (NFKBIA).
Jesús García‐Castillo, Carlos M. Martínez‐Cáceres, Manuel Bernabé‐García, Vicente Munitiz, David Ruiz de Angulo, Pascual Parrilla, Ángeles Ortiz, Luisa F. Martínez de Haro, María L. Cayuela   +8 more
wiley   +1 more source

TrES-1 b: A Case Study in Detecting Secular Evolution of Exoplanet Orbits

The Astronomical Journal
We present a comprehensive analysis of transit, eclipse, and radial velocity data of the hot Jupiter TrES-1 b and confirm evidence of orbital variations on secular timescales.
Simone R. Hagey, Billy Edwards, Angelos Tsiaras, Aaron C. Boley, Anastasia Kokori, Norio Narita, Pedro V. Sada, Filip Walter, Robert T. Zellem, Napaporn A-thano, Kevin B. Alton, Miguel Ángel Álava Amat, Paul Benni, Emmanuel Besson, Patrick Brandebourg, Marc Bretton, Mauro Caló, Martin Valentine Crow, Jean-Christophe Dalouzy, Marc Deldem, Tõnis Eenmäe, Stephane Ferratfiat, Pere Guerra, Gary Vander Haagen, Ken Hose, Adrian Jones, Yves Jongen, Didier Laloum, Stefano Lora, Alessandro Marchini, Jacques Michelet, Matej Mihelčič, Johannes Mieglitz, Eric Miny, David Molina, Mario Morales Aimar, Raphael Nicollerat, Ivo Peretto, Manfred Raetz, François Regembal, Robert Roth, Lionel Rousselot, Mark Salisbury, Darryl Sergison, Anaël Wünsche, Jaroslav Trnka   +45 more
doaj   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

Molecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song, Ting Liu, Qishan Hao, Qiuyun Fang, Xiaoyuan Gong, Yan Li, Zheng Tian, Hui Wei, Min Wang, Jianxiang Wang, Tao Cheng, Yingchang Mi   +11 more
wiley   +1 more source

The Exoplanet Edge: Planets Do Not Induce Observable Transit Timing Variations with a Dominant Transit Timing Variation Period Faster than Half Their Orbital Period

The Astrophysical Journal Letters
Transit timing variations (TTVs) are observed for exoplanets at a range of amplitudes and periods, yielding an ostensibly degenerate forest of possible explanations.
Daniel A. Yahalomi, David Kipping, Eric Agol, David Nesvorný   +3 more
doaj   +1 more source

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

Molecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop, Edgar Cardenas De La Hoz, Hanne Verswyvel, Joey De Backer, Ho Wa Lau, Angela Privat‐Maldonado, Wim Vanden Berghe, Steve Vanlanduit, Evelien Smits, Annemie Bogaerts, Abraham Lin   +10 more
wiley   +1 more source

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

Molecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho, Yubin Hah, Eunsik Yun, Hye In Ka, Aram Lee, Sora Han, Dawn Lee, Sung Wook Kim, Jong Hoon Park, Byung Su Kwon, Young Yang, Jongmin Kim   +11 more
wiley   +1 more source

On the detection of (habitable) super-Earths around low-mass stars using Kepler and transit timing variation method [PDF]

, 2011
Nader Haghighipour, S. Kirste
openalex   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Detection of Earth-mass and super-Earth Trojan planets using transit timing variation method [PDF]

, 2013
Nader Haghighipour, Stephanie Capen, T. C. Hinse   +2 more
openalex   +1 more source