Results 71 to 80 of about 19,159 (254)
TOI-1408: Discovery and Photodynamical Modeling of a Small Inner Companion to a Hot Jupiter Revealed by Transit Timing Variations
The Astrophysical Journal LettersWe report the discovery and characterization of a small planet, TOI-1408 c, on a 2.2 day orbit located interior to a previously known hot Jupiter, TOI-1408 b ( P = 4.42 days, M = 1.86 ± 0.02 M _Jup , R = 2.4 ± 0.5 R _Jup ) that exhibits grazing transits. Judith Korth, Priyanka Chaturvedi, Hannu Parviainen, Ilaria Carleo, Michael Endl, Eike W. Guenther, Grzegorz Nowak, Carina M. Persson, Phillip J. MacQueen, Alexander J. Mustill, Juan Cabrera, William D. Cochran, Jorge Lillo-Box, David Hobbs, Felipe Murgas, Michael Greklek-McKeon, Hanna Kellermann, Guillaume Hébrard, Akihiko Fukui, Enric Pallé, Jon M. Jenkins, Joseph D. Twicken, Karen A. Collins, Samuel N. Quinn, Ján Šubjak, Paul G. Beck, Davide Gandolfi, Savita Mathur, Hans J. Deeg, David W. Latham, Simon Albrecht, David Barrado, Isabelle Boisse, Hervé Bouy, Xavier Delfosse, Olivier Demangeon, Rafael A. García, Artie P. Hatzes, Neda Heidari, Kai Ikuta, Petr Kabáth, Heather A. Knutson, John Livingston, Eder Martioli, María Morales-Calderón, Giuseppe Morello, Norio Narita, Jaume Orell-Miquel, Hanna L. M. Osborne, Dinil B. Palakkatharappil, Viktoria Pinter, Seth Redfield, Howard M. Relles, Richard P. Schwarz, Sara Seager, Avi Shporer, Marek Skarka, Gregor Srdoc, Monika Stangret, Luis Thomas, Vincent Van Eylen, Noriharu Watanabe, Joshua N. Winn +62 moredoaj +1 more sourceCirculating tumor cells: advancing personalized therapy in small cell lung cancer patients
Molecular Oncology, EarlyView.Small cell lung cancer (SCLC) is an aggressive form of lung cancer that spreads rapidly to secondary sites such as the brain and liver. Cancer cells circulating in the blood, “circulating tumor cells” (CTCs), have demonstrated prognostic value in SCLC, and evaluating biomarkers on CTCs could guide treatment decisions such as for PARP inhibitors ...Prajwol Shrestha, Steven Kao, Veronica K. Cheung, Wendy A. Cooper, Nico van Zandwijk, John E. J. Rasko, Dannel Yeo +6 morewiley +1 more sourceTOI-2015 b: A Warm Neptune with Transit Timing Variations Orbiting an Active Mid-type M Dwarf
The Astronomical JournalWe report the discovery of a close-in ( P _orb = 3.349 days) warm Neptune with clear transit timing variations (TTVs) orbiting the nearby ( d = 47.3 pc) active M4 star, TOI-2015.Sinclaire E. Jones, Guđmundur Stefánsson, Kento Masuda, Jessica E. Libby-Roberts, Cristilyn N. Gardner, Rae Holcomb, Corey Beard, Paul Robertson, Caleb I. Cañas, Suvrath Mahadevan, Shubham Kanodia, Andrea S. J. Lin, Henry A. Kobulnicky, Brock A. Parker, Chad F. Bender, William D. Cochran, Scott A. Diddams, Rachel B. Fernandes, Arvind F. Gupta, Samuel Halverson, Suzanne L. Hawley, Fred R. Hearty, Leslie Hebb, Adam Kowalski, Jack Lubin, Andrew Monson, Joe P. Ninan, Lawrence Ramsey, Arpita Roy, Christian Schwab, Ryan C. Terrien, John Wisniewski +31 moredoaj +1 more sourceA comparative study of circulating tumor cell isolation and enumeration technologies in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells were spiked into donor blood to evaluate the recovery rates of the following circulating tumor cell (CTC) enrichment technologies: CellMag™, EasySep™, RosetteSep™, Parsortix® PR1, and Parsortix® Prototype systems. Each method's advantages and disadvantages are described.Volga M Saini, Ezgi Oner, Mark P. Ward, Sinead Hurley, Brian David Henderson, Faye Lewis, Stephen P. Finn, Gerard J. Fitzmaurice, John J. O'Leary, Sharon O'Toole, Lorraine O'Driscoll, Kathy Gately +11 morewiley +1 more sourceCellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients
Molecular Oncology, EarlyView.We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno +31 morewiley +1 more sourceIntegrative analysis of circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients: a comprehensive approach
Molecular Oncology, EarlyView.This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals, Dimitrios Papakonstantinou, Argyro Roumeliotou, Evangelia Pantazaka, Athanasios‐Nasir Shaukat, Athina Christopoulou, Angelos Koutras, Foteinos‐Ioannis Dimitrakopoulos, Vassilis Georgoulias, Anastasia Xagara, Evangelia Chantzara, Fillipos Koinis, Athanasios Kotsakis, Constantinos Stathopoulos, Galatea Kallergi +13 morewiley +1 more sourceTESS Hunt for Young and Maturing Exoplanets (THYME). X. A Two-planet System in the 210 Myr MELANGE-5 Association
The Astronomical JournalYoung (Pa Chia Thao, Andrew W. Mann, Madyson G. Barber, Adam L. Kraus, Benjamin M. Tofflemire, Jonathan L. Bush, Mackenna L. Wood, Karen A. Collins, Andrew Vanderburg, Samuel N. Quinn, George Zhou, Elisabeth R. Newton, Carl Ziegler, Nicholas Law, Khalid Barkaoui, Francisco J. Pozuelos, Mathilde Timmermans, Michaël Gillon, Emmanuël Jehin, Richard P. Schwarz, Tianjun Gan, Avi Shporer, Keith Horne, Ramotholo Sefako, Olga Suarez, Djamel Mekarnia, Tristan Guillot, Lyu Abe, Amaury H. M. J. Triaud, Don J. Radford, Ana Isabel Lopez Murillo, George R. Ricker, Joshua N. Winn, Jon M. Jenkins, Luke G. Bouma, Michael Fausnaugh, Natalia M. Guerrero, Michelle Kunimoto +37 moredoaj +1 more sourceResponse to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes
Molecular Oncology, EarlyView.Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux +16 morewiley +1 more sourceThe TESS-Keck Survey. XVII. Precise Mass Measurements in a Young, High-multiplicity Transiting Planet System Using Radial Velocities and Transit Timing Variations
The Astronomical JournalWe present a radial velocity (RV) analysis of TOI-1136, a bright Transiting Exoplanet Survey Satellite (TESS) system with six confirmed transiting planets, and a seventh single-transiting planet candidate.Corey Beard, Paul Robertson, Fei Dai, Rae Holcomb, Jack Lubin, Joseph M. Akana Murphy, Natalie M. Batalha, Sarah Blunt, Ian Crossfield, Courtney Dressing, Benjamin Fulton, Andrew W. Howard, Dan Huber, Howard Isaacson, Stephen R. Kane, Grzegorz Nowak, Erik A Petigura, Arpita Roy, Ryan A. Rubenzahl, Lauren M. Weiss, Rafael Barrena, Aida Behmard, Casey L. Brinkman, Ilaria Carleo, Ashley Chontos, Paul A. Dalba, Tara Fetherolf, Steven Giacalone, Michelle L. Hill, Kiyoe Kawauchi, Judith Korth, Rafael Luque, Mason G. MacDougall, Andrew W. Mayo, Teo Močnik, Giuseppe Morello, Felipe Murgas, Jaume Orell-Miquel, Enric Palle, Alex S. Polanski, Malena Rice, Nicholas Scarsdale, Dakotah Tyler, Judah Van Zandt +43 moredoaj +1 more sourceAdverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer
Molecular Oncology, EarlyView.We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström +26 morewiley +1 more source
