Results 81 to 90 of about 75,518 (268)
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
Detecting New Planets in Transiting Systems
, 2006 I present an initial investigation into a new planet detection technique that uses the transit timing of a known, transiting planet. The transits of a solitary planet orbiting a star occur at equally spaced intervals in time.
Steffen, Jason H.
core
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Observations and Studies on the Transiting Systems HAT-P-36, XO-2 and WASP-76
The Astronomical JournalWe conducted photometric observations for transit events of three exoplanetary systems HAT-P-36, XO-2 and WASP-76 using the 1 m and 2.4 m telescopes at Yunnan Observatories and the 0.85 m telescope at National Astronomical Observatories of China.
Weilong Wang +10 more
doaj +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
The Astronomical JournalThe eight-planet Kepler-90 system exhibits the greatest multiplicity of planets found to date. All eight planets are transiting and were discovered in photometry from the NASA Kepler primary mission. The two outermost planets, g ( P _g = 211 days) and h
David E. Shaw +30 more
doaj +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
The Astronomical JournalWe present new results for the hot Jupiters HAT-P-16b, TOI-1516b, and TOI-2046b, based on photometric observations collected using both space- and ground-based facilities.
E. Sonbas +7 more
doaj +1 more source
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
Detailed Architecture of the L 98-59 System and Confirmation of a Fifth Planet in the Habitable Zone
The Astronomical JournalThe L 98-59 system, identified by TESS in 2019, features three transiting exoplanets in compact orbits of 2.253, 3.691, and 7.451 days around an M3V star, with an outer 12.83 day nontransiting planet confirmed in 2021 using ESPRESSO.
Charles Cadieux +14 more
doaj +1 more source