Transit timing variation method - Open Access .click

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A Fourth Planet in the Kepler-51 System Revealed by Transit Timing Variations

The Astronomical Journal
Kepler-51 is a ≲1 Gyr old Sun-like star hosting three transiting planets with radii ≈6–9 R _⊕ and orbital periods ≈45–130 days. Transit timing variations (TTVs) measured with past Kepler and Hubble Space Telescope (HST) observations have been ...
Kento Masuda +51 more
doaj +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam +9 more
wiley +1 more source

Investigating the Atmospheric Mass Loss of the Kepler-105 Planets Straddling the Radius Gap

The Astronomical Journal
An intriguing pattern among exoplanets is the lack of detected planets between approximately 1.5 R _⊕ and 2.0 R _⊕ . One proposed explanation for this “radius gap” is the photoevaporation of planetary atmospheres, a theory that can be tested by studying ...
Aaron Householder +23 more
doaj +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé +7 more
wiley +1 more source

Giant Outer Transiting Exoplanet Mass (GOT ‘EM) Survey. IV. Long-term Doppler Spectroscopy for 11 Stars Thought to Host Cool Giant Exoplanets

The Astrophysical Journal Supplement Series
Discovering and characterizing exoplanets at the outer edge of the transit method’s sensitivity has proven challenging owing to geometric biases and the practical difficulties associated with acquiring long observational baselines.
Paul A. Dalba +31 more
doaj +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan +10 more
wiley +1 more source

Tidally Heated Sub-Neptunes, Refined Planetary Compositions, and Confirmation of a Third Planet in the TOI-1266 System

The Astronomical Journal
TOI-1266 is a benchmark system of two temperate (
Michael Greklek-McKeon +40 more
doaj +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka +10 more
wiley +1 more source

The Exoplanet Edge: Planets Do Not Induce Observable Transit Timing Variations with a Dominant Transit Timing Variation Period Faster than Half Their Orbital Period

The Astrophysical Journal Letters
Transit timing variations (TTVs) are observed for exoplanets at a range of amplitudes and periods, yielding an ostensibly degenerate forest of possible explanations.
Daniel A. Yahalomi +3 more
doaj +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu +15 more
wiley +1 more source

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