Results 41 to 50 of about 486,539 (269)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Scale-invariant transition probabilities in free word association trajectories

Frontiers in Integrative Neuroscience, 2009
Free-word association has been used as a vehicle to understand the organization of human thoughts. The original studies relied mainly on qualitative assertions, yielding the widely intuitive notion that trajectories of word associations are structured ...
Martin Elias Costa, Flavia Bonomo, Mariano Sigman   +2 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

A note on computing average state occupation times

Demographic Research, 2014
Objective: This review discusses how biometricians would probably compute or estimate expected waiting times, if they had the data. Methods: Our framework is a time-inhomogeneous Markov multistate model, where all transition hazards are allowed to be ...
Jan Beyersmann, Hein Putter
doaj   +1 more source

Markov chains as a proxy for the predictive memory representations underlying mismatch negativity

Frontiers in Human Neuroscience, 2023
Events not conforming to a regularity inherent to a sequence of events elicit prediction error signals of the brain such as the Mismatch Negativity (MMN) and impair behavioral task performance.
Erich Schröger, Urte Roeber, Nina Coy, Nina Coy   +3 more
doaj   +1 more source

A multistate dynamic site occupancy model for spatially aggregated sessile communities

, 2016
Markov community models have been applied to sessile organisms because such models facilitate estimation of transition probabilities by tracking species occupancy at many fixed observation points over multiple periods of time.
Fukaya, Keiichi, Nakaoka, Masahiro, Noda, Takashi, Okuda, Takehiro, Royle, J. Andrew   +4 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Experimental Determination of Electron Transition Probabilities in Elementary Electron-Phonon Scattering Processes Using Electron-Energy-Loss Spectroscopy: The Example of Graphite

, 2010
We have investigated coupling constants in elementary electron-phonon scattering processes on a graphite surface by the combined use of high-resolution electron-energy-loss spectroscopy (HREELS) and very low-energy electron diffraction (VLEED). HREELS is
Ishida, Yasuchika, Kamide, Kenji, Kato, Shuhei, Niikura, Ryota, Oshima, Chuhei, Yanagisawa, Hirofumi, Yorisaki, Toma   +6 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Basic parametric analysis for a multi-state model in hospital epidemiology

BMC Medical Research Methodology, 2017
Background The extended illness-death model is a useful tool to study the risks and consequences of hospital-acquired infections (HAIs). The statistical quantities of interest are the transition-specific hazard rates and the transition probabilities as ...
Maja von Cube, Martin Schumacher, Martin Wolkewitz   +2 more
doaj   +1 more source