Results 21 to 30 of about 8,459 (174)
Structure and function of the transketolase from Mycobacterium tuberculosis and comparison with the human enzyme [PDF]
Open Biology, 2012 The transketolase (TKT) enzyme in Mycobacterium tuberculosis represents a novel drug target for tuberculosis treatment and has low homology with the orthologous human enzyme.
Elizabeth Fullam +4 more
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Biomedicines, 2021 Thiamine helps transketolase in removing toxic metabolites, counteracting high glucose-induced damage in microvascular cells, and progression of diabetic retinopathy/nephropathy in diabetic animals.
Aurora Mazzeo +6 more
doaj +1 more source
Antioxidants, 2023 Crosstalk of renal epithelial cells with interstitial fibroblasts plays an important role in kidney pathophysiology. A previous study showed that crosstalk between renal epithelial cells and renal fibroblasts protects against acidosis-induced damage.
Marie-Christin Schulz +5 more
doaj +1 more source
Thiamine Use in Hospitalized Patients: A Clinical Review. [PDF]
J Nutr MetabThiamine, or vitamin B1, is a water‐soluble vitamin necessary for multiple metabolic processes throughout the human body. Thiamine is primarily obtained from our diet and is found in sources such as whole grains, legumes, and pork. Short bowel syndrome, severe malnutrition, alcohol use disorder, or diuretic use can all lead to thiamine deficiency ...
Rosewarne RE, Farina N.
europepmc +2 more sources
Structure-Based Discovery and Synthesis of Potential Transketolase Inhibitors
Molecules, 2018 Transketolase (TKL) plays a key role in plant photosynthesis and has been predicted to be a potent herbicide target. Homology modeling and molecular dynamics simulation were used to construct a target protein model.
Jingqian Huo +6 more
doaj +1 more source
Is transketolase-like protein, TKTL1, transketolase?
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2013 Until recently it was assumed that the transketolase-like protein (TKTL1) detected in the tumor tissue, is catalytically active mutant form of human transketolase (hTKT). Human TKT shares 61% sequence identity with TKTL1. And the two proteins are 77% homologous at the amino acid level.
Meshalkina, Ludmilla E. +4 more
openaire +2 more sources
Mìžnarodnij Endokrinologìčnij Žurnal, 2019 The review article presents an analysis of the literature on the effect of thiamine and its derivatives on the metabolism in cells and its role in the pathogenesis of complications of diabetes mellitus.
K. Singh, T. Yuzvenko, D. Kogut
doaj +1 more source
Diphenyl urea derivatives as inhibitors of transketolase: a structure-based virtual screening. [PDF]
PLoS ONE, 2012 Transketolase is an enzyme involved in a critical step of the non-oxidative branch of the pentose phosphate pathway whose inhibition could lead to new anticancer drugs. Here, we report new human transketolase inhibitors, based on the phenyl urea scaffold,
Cristian Obiol-Pardo +3 more
doaj +1 more source
Microbiology Spectrum, 2023 Despite advances in rapid molecular techniques for tuberculosis (TB) diagnostics, there is an unmet need for a point-of-care, nonsputum-based test. Previously, through a T7 phage antigen display platform and immunoscreening, we identified that the serum ...
Jaya Talreja +4 more
doaj +1 more source
Transketolase Is Identified as a Target of Herbicidal Substance α-Terthienyl by Proteomics
Toxins, 2018 α-terthienyl is a natural phytotoxin isolated originally from Flaveria bidentis (L.) Kuntze. The bioassay presented here shows the strong herbicidal activity of α-terthienyl on Digitaria sanguinalis, Arabidopsis thaliana and Chlamydomonas reinhardtii ...
Bin Zhao +4 more
doaj +1 more source