Results 51 to 60 of about 8,459 (174)

TKTL1 is overexpressed in a large portion of non-small cell lung cancer specimens

Diagnostic Pathology, 2008
In several tumors the transketolase activity, controlled inter alia by enzymes of the pentose phosphate pathway which is an alternative, energy generating reaction-cascade to glycolysis, has been correlated with proliferation.
Zabel Peter, Vollmer Ekkehard, Branscheid Detlev, Kähler Daniel, Schultz Holger, Goldmann Torsten   +5 more
doaj   +1 more source

Regulation of R‐Loop Dynamics by Proteins and Long Noncoding RNAs: An Emerging Paradigm for Cancer Treatment

Cancer Science, Volume 117, Issue 2, Page 297-307, February 2026.
R‐loops are three‐stranded nucleic acid structures whose dysregulation leads to genomic instability and cancer progression. This review summarizes the protein and lncRNA machineries that regulate R‐loop dynamics and discusses the therapeutic potential of targeting these pathways in cancer.
Miho M. Suzuki, Keiko Shinjo, Tatsunori Nishimura, Yutaka Kondo   +3 more
wiley   +1 more source

NAD⁺ Reduction in Glutamatergic Neurons Induces Lipid Catabolism and Neuroinflammation in the Brain via SARM1

Advanced Science, Volume 13, Issue 6, 30 January 2026.
NAD⁺ homeostasis maintains neuronal integrity through opposing actions of NMNAT2 and SARM1. Loss of NMNAT2 in glutamatergic neurons reprograms cortical metabolism from glucose to lipid catabolism, depletes lipid stores, and triggers inflammation and neurodegeneration.
Zhen‐Xian Niou, Sen Yang, Andrea Enriquez, Nino A. Espinas, Anoosha Sri, Caliel D. Hines, Jason M. Tennessen, Chia‐Shan Wu, Jui‐Yen Huang, Hui‐Chen Lu   +9 more
wiley   +1 more source

ALDOA‐Mediated Metabolic Reprogramming is a Targetable Vulnerability for Ferroptosis Sensitization in Cancer

Advanced Science, Volume 13, Issue 6, 30 January 2026.
ALDOA‐depletion‐mediated glycolytic reprogramming promotes autophagy‐mediated degradation of MBOAT2, increasing the ratio of phospholipids containing pro‐ferroptotic polyunsaturated fatty acids over anti‐ferroptotic monounsaturated fatty acids, and thus sensitizing cancer cells to ferroptosis.
Pengqi Wang, Kezhang He, Bowen Wang, Wei Zhou, Ying Zhang, Tianhua Ma, Sheng Ding   +6 more
wiley   +1 more source

Severe thiamine deficiency in eastern Baltic cod (Gadus morhua).

PLoS ONE, 2020
The eastern Baltic cod (Gadus morhua) population has been decreasing in the Baltic Sea for at least 30 years. Condition indices of the Baltic cod have decreased, and previous studies have suggested that this might be due to overfishing, predation, lower ...
Josefin Engelhardt, Oscar Frisell, Hanna Gustavsson, Tomas Hansson, Rajlie Sjöberg, Tracy K Collier, Lennart Balk   +6 more
doaj   +1 more source

Biophysical characterization of the inactivation of E. coli transketolase by aqueous co-solvents

Scientific Reports, 2021
Transketolase (TK) has been previously engineered, using semi-rational directed evolution and substrate walking, to accept increasingly aliphatic, cyclic, and then aromatic substrates.
Phattaraporn Morris, Ribia García-Arrazola, Leonardo Rios-Solis, Paul A. Dalby   +3 more
doaj   +1 more source

Genetic Factors Associated with Toe Walking in Children

Вопросы современной педиатрии, 2020
The article describes genetic factors associated with toe walking in children. Association of gait abnormality with variants in genes listed below is shown: PMP22 (peripheral myelin protein 22), EGR2 (early growth response protein 2), AIFM1 (apoptosis ...
David Pomarino, Anneke Thren, Stefaine Morigeau, Johanna R. Thren, Anna A. Emelina   +4 more
doaj   +1 more source

Genome‐Wide Association Study and RNA Sequencing Identify Candidate Genes Regulating Nitrogen Use Efficiency and Associated Traits in Sorghum (Sorghum bicolor (L.) Moench)

Food and Energy Security, Volume 15, Issue 1, January/February 2026.
ABSTRACT Sorghum (Sorghum bicolor L. Moench) is a resilient cereal crop with remarkable adaptability to diverse environments. Nitrogen use efficiency (NUE) is critical for improving sorghum yields, resource utilization, livelihood security, and environmental sustainability of the target ecologies.
Srikanth Bollam, Laavanya Rayaprolu, Kirandeep Kaur Romana, Pradeep Ruperao, Sivasubramani Selvanayagam, Anil Kumar Vemula, Gopikrishna Adapala, Vinod Kumar Valluri, Prasad Bajaj, Abhishek Rathore, Damaris A. Odeny, Rakesh K. Srivastava, Santosh P. Deshpande, Rajeev Gupta   +13 more
wiley   +1 more source

IL21—STAT3 controls the pentose phosphate pathway to support metabolic reprogramming and tumor progression in chronic lymphocytic leukemia

HemaSphere, Volume 10, Issue 1, January 2026.
Abstract Studying how microenvironmental cues influence metabolic reprogramming can uncover mechanisms driving tumor progression. Using an in vitro model with proliferative stimuli of the in vivo lymph node niche (LN)—including interleukin‐21 (IL‐21)—we examined metabolic rewiring in chronic lymphocytic leukemia (CLL) cells. We found that the metabolic
Rosita Del Prete, Vjola Tusha, Helga Simon‐Molas, Virginia Anna Gazziero, Federica Nardi, Roberta Drago, Gaia Bartolini, Danilo Licastro, Margherita Malchiodi, Cristina Mariottini, Giuseppe Marotta, Giulio Caravagna, Stefano Bruscoli, Eric Eldering, Alessandro Gozzetti, Monica Bocchia, Anna Kabanova   +16 more
wiley   +1 more source

Overexpression of Transketolase Relieves xylA Repression and Enhances Xylose Utilization in Saccharomyces cerevisiae During Mixed Sugar Fermentation

GCB Bioenergy
Metabolic engineering of Saccharomyces cerevisiae has enabled xylose‐fermenting yeast strains. However, the bioavailability dilemma of xylose has become the core bottleneck restricting the economy of lignocellulose.
Si Xu, Wanli Cheng, Huanan Li, Jiashu Liu, Kexin Chen, Zhengbing Jiang   +5 more
doaj   +1 more source