Results 31 to 40 of about 226,342 (310)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Kesalahan Terjemahan Konjungtor -te pada Kalimat Majemuk Bahasa Jepang: Kajian Struktur dan Makna

open access: yesJLA (Jurnal Lingua Applicata), 2019
In translating Japanese compound sentences, generally, students still have difficulty in interpreting the meaning of the -te verb which functioned as a conjunction (-te conjunction) in compound sentences. Semantically, the -te verb form has some meanings
Saidatun Nishfullayli   +1 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

Cognitive Dynamics in Language Mediation Insights from Translation, Audiovisual Translation, and Interpreting Studies [PDF]

open access: yesSHS Web of Conferences
This article ventures into the intricate world of cognitive processes underlying translation and interpreting. It presents a meticulous examination of the complex mental processes and cognitive strategies that translators and interpreters employ in their
Wang Jianing
doaj   +1 more source

IAD annual report [PDF]

open access: yes, 2006
The Institute for Aboriginal Development Incorporated (IAD) was established by the Uniting Church in 1969 to assist community development for Aboriginal people and provide cross-cultural education between Aboriginal and non-Aboriginal society.
Institute for Aboriginal Development
core  

Trunk muscle activity during drop jump performance in adolescent athletes with back pain [PDF]

open access: yes, 2018
It was with great interest we read the recently published article “Trunk Muscle Activity during Drop Jump Performance in Adolescent Athletes with Back Pain.” Investigating back pain (BP) in adolescents is commendable as there is growing evidence that for
Caneiro, J.   +5 more
core   +3 more sources

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Public service interpreting and translating: providing human rights and access to social justice

open access: yesRUDN Journal of Law, 2013
The article analizes the role of public service interpreting and translation (PSIT) in today multicultural world. The EU multilingual polices and experience in providing human rights through language services are highlighted within the multilingualism ...
- Carmen Valero-Garcés   +1 more
doaj  

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