Results 151 to 160 of about 22,114 (260)

Effects of gamification on the engagement and translation proficiency of the Chinese EFL learners: a case of Quizizz. [PDF]

Front Psychol
Zhang J.
europepmc   +1 more source

A Phase‐Resolved Geometric Deep Learning Framework Maps Structural Determinants of Disease‐Associated Protein Aggregation and Guides Suppressor Design

Advanced Science, EarlyView.
SKALE 2.0 maps disease‐associated protein aggregation as a phase‐resolved structural process, linking mutation‐induced geometric perturbations to nucleation, elongation, and suppressor design. Across neurodegenerative proteins, the framework reveals cryptic aggregation vulnerabilities, separates phase‐concordant and phase‐switching mutations, and ...
Jia Shen Sio, Wei Xuan Wilson Loo, Yan Shan Loo, Wen Xin Tan, Hui Xuan Lim, Huitao Liu, Chen Seng Ng   +6 more
wiley   +1 more source

Detection and characterization of protein methylation in bacteriophages and their host, <i>Cellulophaga baltica</i>, during infection. [PDF]

mSystems
Stai AJ, Howard-Varona C, Urvoy M, Gittrich MR, Sullivan MB, Hettich RL.   +5 more
europepmc   +1 more source

ZNF33B Promotes Japanese Encephalitis Virus Infection by Regulating the Stability of M6A‐Modified Trim25 to Control the Autophagy Process

Advanced Science, EarlyView.
Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du, Chunwei Li, Jiyuan Luo, Huizhi Zhang, Jinyan Zhang, Suya Wang, Huanchun Chen, Hongli Xu, Xiangmin Li, Ping Qian   +9 more
wiley   +1 more source

Implementation of a clinical decision support tool for postpartum depression: protocol for a prospective randomised clinical trial. [PDF]

BMJ Open
Joly R, Gossey TJ, Daoud AK, Zhang Y.
europepmc   +1 more source

NAD+ Metabolism Licenses Zygotic Genome Activation via PARP7‐Mediated ADP‐Ribosylation of UHRF1 in Mouse Early Embryos

Advanced Science, EarlyView.
This study uncovers a metabolic‐epigenetic axis licensing zygotic genome activation (ZGA) in mouse embryos. A developmental decline in NAD+ levels activates PARP7, which mono‐ADP‐ribosylates and stabilizes UHRF1. This modification promotes the establishment of permissive histone acetylation marks, thereby facilitating timely ZGA.
Guangyi Cao, Ziqi Zhang, Anqi Chen, Yanbo Liu, Yuling Lin, Lina Yu, Ruixin Shi, Aolei Guo, Yan Mao, Ganggui Lou, Chaojun Li, Luhong Wen, Guijun Yan, Haixiang Sun   +13 more
wiley   +1 more source

Iron-sulfur cofactors in nucleic acid metabolism and protein synthesis: Assembly, delivery, and putative roles in cellular and viral systems. [PDF]

J Biol Chem
Maio N, Rouault TA.
europepmc   +1 more source

Tandem Duplication‐Driven Neofunctionalization of UDP‐Glycosyltransferases Shapes the Diversification of Triterpenoid Saponins in the Cucurbitaceae

Advanced Science, EarlyView.
We present a chromosome‐level genome assembly of Siraitia grosvenorii and, through comparative genomics, uncover a conserved UGT73 tandem array driving triterpenoid saponin diversification in Cucurbitaceae. Crystalized SgUGT73AM30 further reveals the regioselectivity mechanism underlying its catalytic activity.
Guangyi Wang, Mengmeng Li, Xuehui Dai, Yanchen Zhang, Yuhan Wu, Zhaotao Yan, Chenfei Tian, Hongkai Fan, Haili Liu, Xiaowei Zhang, Yiming Yang, Jiayu Lu, Yuwei Sun, Yong Wang   +13 more
wiley   +1 more source

University presses, academic books, and authors in Ibero-America: a systematic review. [PDF]

Front Res Metr Anal
Calle Pesántez SE, Suárez-Giraldo C, Ramos Alonso A, Méndez-Rátiva CP, Abadía AA.   +4 more
europepmc   +1 more source

Magnetotransport Signatures of Spin–Orbit Coupling in High‐Temperature Cuprate Superconductors

Advanced Science, EarlyView.
Large angle‐dependent magnetoresistance and planar Hall effects emerge at the superconducting transition of YBa2Cu3O7−x$\mathrm{YBa_2Cu_3O_{7-x}}$ thin films. These anomalous transport signatures, absent in the normal state, point to spin‐polarized quasiparticle dynamics enabled by an unexpected spin–orbit coupling landscape in cuprate superconductors,
Aleix Barrera, Huidong Li, Thomas Gunkel, Jordi Alcalá, Silvia Damerio, Can Onur Avci, Anna Palau   +6 more
wiley   +1 more source