Results 151 to 160 of about 6,898,913 (302)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Advertising across cultures, where translation is nothing... or everything

, 2018
This article deals with the concept of 'translation' in the field of advertising, often known as 'copy adaptation.' The different advertising strategies used when adverts are published or broadcast in different countries involve different approaches to ...
Cruz García, Laura
core  

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Is machine translation gisting translation?

This article explores the question of whether machine translation (MT) is translation by analyzing the processes involved in a translator-led ‘traditional’ process against those involved in receiver-led MT gisting. Backed by evidence from recent research
Nurminen, Mary
core   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

How knowledge translation interventions involving health policy decision makers are evaluated: a scoping review protocol. [PDF]

HRB Open Res
Phillips A, Macenaite M, Byrne M, Treweek S, Toomey E.   +4 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Arthroscopic Lateral Tibial Plateau Translation Correlates With Pivot-Shift Severity in Anterior Cruciate Ligament-Deficient Knees. [PDF]

Arthrosc Sports Med Rehabil
Rivarola H, Helito C, Collazo C, Palanconi M, Meninato M, Peñaherrera-Carrillo C, Barros Castro A, Rivarola B, Endara Urresta F.   +8 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Assessment of LLMs on basic bioinformatics tasks requiring multi-step reasoning and code writing. [PDF]

Bioinformatics
Rajesh V, Blumberg M, Jain S, Siwo GH.
europepmc   +1 more source