Results 121 to 130 of about 4,480,419 (303)

An exploratory case study investigating the implementation of a novel knowledge translation strategy in a pandemic: the Pandemic Practice Champion. [PDF]

open access: yesImplement Sci Commun, 2022
Stevens B   +7 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Exploring conceptualizations of knowledge translation, transfer and exchange across public health in one UK region: a qualitative mapping study [PDF]

open access: yes, 2014
Objectives - Knowledge translation (KT) is becoming common vocabulary, but as a concept it is not clearly defined. Many related terms exist; these are often used interchangeably and given multiple interpretations.
Steven, Alison   +5 more
core   +1 more source

Lattice score based data cleaning for phrase-based statistical machine translation [PDF]

open access: yes, 2010
Statistical machine translation relies heavily on parallel corpora to train its models for translation tasks. While more and more bilingual corpora are readily available, the quality of the sentence pairs should be taken into consideration.
Way, Andy   +2 more
core   +2 more sources

Die vertaling en lokalisering van Terminologie van het tolken vir ’n Suid-Afrikaanse teikengehoor

open access: yesStellenbosch Papers in Linguistics, 2017
Although much research is currently undertaken on interpreting in South Africa, the profession and academic discourse lack standardised interpreting terminology, especially in the indigenous languages.
Cornelius, Eleanor , Pienaar, Marné
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Operetta in Turkey: A case study of Gün’s translation of Strauss’s Die Fledermaus

open access: yes, 2020
The genre operetta has long found itself a place in the musical polysystem of Turkey and become one of the borrowed forms of art symbolizing modernity through Turkey’s Westernization process.
Soy, Özlem Şahin   +2 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

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