Results 61 to 70 of about 1,513,840 (316)

Blackfeet innovation pathways to food sovereignty: sustainability through indigenous-led research partnerships

Frontiers in Sustainable Food Systems
The Blackfeet Nation in northwestern Montana, United States, is implementing its Agriculture Resource Management Plan (ARMP), an Indigenous-led, sustainable agriculture plan prioritizing economic development for Indigenous producers, intergenerational ...
Kimberly L. Paul, Kristin T. Ruppel, Kristin T. Ruppel, Micaela M. Young, Laura Caplins, Jill Falcon Ramaker, Christopher J. Carter, William B. Seeley, Christen Falcon, Andrew Berger   +9 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

To be or not to be translational.

Translational medicine @ UniSa, 2013
Translational Research means different things to different people, but it seems crucial to almost everyone. This discipline, although defined differently in academia, regulatory institutions, and industry, shares the fundamental vision of Translational Medicine, which efficiently and effectively translates basic scientific findings relevant to human ...
Anastasio Antonio, Armenante Annnunziata, Gimigliano Anna, MOSCARINO, AZZURRA, PANZERA, STEFANIA, ROMANO, ROSALBA, Russo Ilaria, Scarpati Giuliana   +7 more
openaire   +3 more sources

UMCCTS Newsletter, June 2023

, 2023
This is the June 2023 issue of the UMass Center for Clinical and Translational Science Newsletter containing news and events of interest.Supported by the National Center for Advancing Translational Sciences, National Institutes of Health, through Grants ...
UMass Center for Clinical and Translational Science
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Multimodal AI-based systems in major depressive disorder: a review of clinical and translational applications

Frontiers in Digital Health
Major Depressive Disorder (MDD) is one of the most prevalent and disabling psychiatric conditions worldwide, involving alterations in mood regulation, cognitive function, sleep, and physiological systems.
Claudio Crema, Silvia De Francesco, Cesare Michele Baronio, Alberto Boccali, Claudio Demaria, Giovanni Battista Tura, Damiano Archetti, Alberto Redolfi   +7 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Evaluation of Andrographis paniculata in a mouse model of influenza A viral infection using oral administration and a translationally relevant dose

Frontiers in Pharmacology
IntroductionEthnobotanically, Andrographis paniculata aerial parts have been used to alleviate the symptoms of viral infections, colds, and sore throats.
Kashif Shamim, Grace C. Burnett, Jin Zhang, Nessma H. Ahmed, Shabana I. Khan, Shabana I. Khan, Amar G. Chittiboyina, Amar G. Chittiboyina, Amar G. Chittiboyina, Ikhlas A. Khan, Ikhlas A. Khan, Gailen D. Marshall, Gailen D. Marshall, John T. Bates, John T. Bates, John T. Bates, Nirmal D. Pugh   +16 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Innovative micro physiological systems for vaccine development

Human Vaccines & Immunotherapeutics
Micro Physiological systems (MPS) are biomimetic platforms that reconstitute the complex architecture of human organs and tissues in vitro. MPSs have the capacity to improve clinical development pipelines as they address certain translational limitations
Kendra Reynaud, Scott Atwell, Christophe Védrine, Cyril Guyard, Laurent Beloeil   +4 more
doaj   +1 more source