Results 41 to 50 of about 298,243 (256)

Liver-nervous system axis: pathways, dysregulation, and translational perspectives

Journal of Neuroinflammation
The liver and the nervous system form a dynamic bidirectional regulatory network through the liver-nervous system axis, which is crucial for maintaining metabolic homeostasis, immune balance, and the integrity of neural function in the body. However, the
Donglin Hao, Yuebo Hu, Wei Luo, Shihui Li, Yongmin Yan, Jing Zhou   +5 more
doaj   +1 more source

Gait Analysis Using Walking-Generated Acceleration Obtained from Two Sensors Attached to the Lower Legs

Sensors
Gait evaluation approaches using small, lightweight inertial sensors have recently been developed, offering improvements in terms of both portability and usability.
Ayuko Saito, Natsuki Sai, Kazutoshi Kurotaki, Akira Komatsu, Shinichiro Morichi, Satoru Kizawa   +5 more
doaj   +1 more source

Neurovisceral interactions within the brain-heart axis as the basis of neurocardiology

Кардиоваскулярная терапия и профилактика, 2022
The use of a systematic approach to the study of the etiology of a certain pathology makes it possible to improve the understanding of its pathogenesis, as well as to develop more effective diagnostic and therapeutic approaches, including improving the ...
A. S. Limonova, K. N. Germanova, M. V. Gantman, M. A. Nazarova, K. V. Davtyan, P. A. Novikov, A. A. Sukmanova, A. V. Tarasov, M. S. Kharlap, A. I. Ershova, O. M. Drapkina   +10 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

The depressor axis of the renin–angiotensin system and brain disorders: a translational approach

Clinical Science, 2018
All the components of the classic renin–angiotensin system (RAS) have been identified in the brain. Today, the RAS is considered to be composed mainly of two axes: the pressor axis, represented by angiotensin (Ang) II/angiotensin-converting enzyme/AT1 receptors, and the depressor and protective one, represented by Ang-(1–7)/ angiotensin-converting ...
Gironacci, Mariela Mercedes, Vicario, Augusto, Cerezo, Gustavo, Silva, Mauro Gastón   +3 more
openaire   +3 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Characteristic rotational behaviors of rod-shaped cargo revealed by automated five-dimensional single particle tracking

Nature Communications, 2017
Distinguishing rotational motions from translational motions in the z-axis has been a long-standing challenge. Here the authors develop a five-dimensional single particle tracking method to detect rotational behaviors of nanocargos during clathrin ...
Kuangcai Chen, Yan Gu, Wei Sun, Bin Dong, Gufeng Wang, Xinxin Fan, Tian Xia, Ning Fang   +7 more
doaj   +1 more source

The Axis-Translation and Osmotic Techniques in Shear Testing of Unsaturated Soils: A Comparison

Soils and Foundations, 2007
ABSTRACT Matric suction in the laboratory testing of an unsaturated specimen is usually controlled by the axis-translation technique or the osmotic technique. To investigate possible differences in the axis-translation and osmotic techniques in shear testing of unsaturated soils, three series of unsaturated triaxial shear tests were conducted on a ...
Ng, Charles Ww, Cui, Yu-Jun, Chen, Rui, Delage, Pierre   +3 more
openaire   +4 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source