Results 41 to 50 of about 1,480,919 (260)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Subtalar joint kinematics defined by a rotational axis translating along the posterior talocalcaneal facet

Scientific Reports
The subtalar joint is essential for the normal function of the human foot during bipedal walking, with its kinematics being pivotal for understanding foot biomechanics, disorders, and evolution.
Naomichi Ogihara, Yuka Matsumoto, Hiroyuki Seki, Takeo Nagura, Nobuaki Imanishi, Masahiro Jinzaki, Motoharu Oishi, Hideki Endo, Gen Suwa   +8 more
doaj   +1 more source

Discrimination of the shot distance by putter head motions of golf

Nihon Kikai Gakkai ronbunshu, 2015
In previous study, we proposed three dimensional motion measurement system which was composed of gyro sensor and infrared sensor to measure golf putter head motion.
Mayu TSUCHIYA, Masaki HOKARI
doaj   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Post-Translational Circadian Regulation of Inflammation: Mechanistic Control of Immune Signaling Networks

Immuno
Circadian rhythms impose temporal organization on immune function, shaping host responses to infection, injury, and chronic disease. While transcriptional control by core clock components such as CLOCK and BMAL1 has been extensively characterized, this ...
Derek Gu, Vincent Yuan
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Biodynamics of the seated human body with dual-axis excitation: nonlinearity and cross-axis coupling

, 2012
The apparent mass of the seated human body and the transmissibility to the upper-body (i.e., the spine and the pelvis) during vertical vibration excitation have been reported to have resonance frequencies around 5 Hz.
Zheng, Guangtai
core   +1 more source

Liver-nervous system axis: pathways, dysregulation, and translational perspectives

Journal of Neuroinflammation
The liver and the nervous system form a dynamic bidirectional regulatory network through the liver-nervous system axis, which is crucial for maintaining metabolic homeostasis, immune balance, and the integrity of neural function in the body. However, the
Donglin Hao, Yuebo Hu, Wei Luo, Shihui Li, Yongmin Yan, Jing Zhou   +5 more
doaj   +1 more source

Current Status of Translational Research on Functional Dyspepsia

The Korean Journal of Gastroenterology, 2016
Functional dyspepsia (FD) has a diverse pathophysiology and treatment is difficult. Translational research to understand its pathophysiology is underway.
Jae-Ho Park, Jong Wook Kim, Jong Kyu Park, Cheol Min Shin, Kee Wook Jung   +4 more
doaj   +1 more source

Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease

FEBS Letters, EarlyView.
Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim, Thi Thanh Mai Tran, Nakyung Kang, Min‐Woo Lee, Mihye Lee   +4 more
wiley   +1 more source