Results 61 to 70 of about 1,480,919 (260)

Apparent Masses of Seated Human Body with Tri-Axis Vibration: Combined Effect of In-Line Magnitude, Cross-Axis Magnitude, and Backrest Inclination

Applied Sciences
Despite the presence of multi-axis vibration in many vehicles, biodynamic responses of the human body are mostly studied under single-axis conditions.
Weitan Yin, Yi Qiu, Fengqin Li, Zefeng Lin, Chi Liu, Xu Zheng, Qianqian Chen   +6 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Growing Translational Plant Sciences

, 2015
The annual magazine for the Virginia Tech Translational Plant Sciences (TPS) graduate program, formerly Molecular Plant Sciences (MPS)
Translational Plant Sciences, Fralin Life Sciences Institute   +1 more
core  

The microbiota-gut-brain axis: novel mechanisms and therapeutic frontiers in obesity and type 2 diabetes

npj Biofilms and Microbiomes
The microbiota-gut-brain axis (MGBA) is a bidirectional network linking gut microbes to the CNS. This review elucidates how microbial messengers—short-chain fatty acids, bile acids, neuroactive metabolites, and extracellular vesicles—drive obesity and ...
Kaile Ma, Qiqi Zhang, Rui Hao, Xiao Sun, Jing Jia, Min Li   +5 more
doaj   +1 more source

HIF1α-PHD1-FOXA1 Axis Orchestrates Hypoxic Reprogramming and Androgen Signaling Suppression in Prostate Cancer

Cells
Hypoxia is a hallmark of aggressive prostate cancer, but how it disrupts lineage-specific transcriptional programs to drive progression remains unclear. Here, we identify the HIF1α-PHD1-FOXA1 axis as a critical mediator of hypoxic adaptation and androgen
Limiao Liang, Dandan Dong, Jiaxue Sun, Qin Zhang, Xiayun Yang, Gong-Hong Wei, Peng Zhang   +6 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Growing Translational Plant Sciences

, 2016
The annual magazine for the Virginia Tech Translational Plant Sciences (TPS) graduate program, formerly Molecular Plant Sciences (MPS)
Translational Plant Sciences, Fralin Life Sciences Institute   +1 more
core  

Modeling of an Impact Wrench for Use in Reducing Hand–Arm Vibrations

Machines
Impact wrenches are widely used in construction and automotive industries, yet they generate harmful vibrations that pose health risks to operators and reduce tool usability.
Tashari ter Braack, Donald L. Margolis
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source