Results 51 to 60 of about 404,871 (284)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Knowledge Production and Transfer in the Iranian Oral Health Research Centers: Based on Research Evaluation from 2019 to 2021

Frontiers in Dentistry
Due to the global burden of oral diseases, knowledge production and transfer are essential for clinical practice and policy. This descriptive study assessed 28 Iranian Oral Health Research Centers (OHRCs) from 13 medical universities (2019–2021), using ...
Katayoun Falahat, Monir Baradaran Eftekhari, Aboozar Ramezani   +2 more
doaj   +1 more source

Translational Research from an Informatics Perspective [PDF]

, 2007
Clinical and translational research (CTR) is an essential part of a sustainable global health system. Informatics is now recognized as an important en-abler of CTR and informaticians are increasingly called upon to help CTR efforts.
Bernstam, Elmer, Johnson-Throop, Kathy A., Meric-Bernstam, Funda, Smith, Jack W., Turley, James P.   +4 more
core   +1 more source

Tracking the performance of an R&D programme in the biomedical sciences [PDF]

, 2016
Pre-refereed version of manuscript accepted for publication in Research EvaluatioN: arXiv:1602.04049This article aims at offering an evaluation framework of an R&D programme in the biomedical sciences.
Cabezas-Clavijo, Álvaro, Jiménez-Contreras, Evaristo, Robinson-García, Nicolás   +2 more
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

BATRACIO: BAsic, TRAnslational, Clinical, Research Phase Identification in BiOmedical Publications

IEEE Access
The increasing interest from research agencies, governments, and universities in understanding research funding and prioritising research efforts has highlighted the need for reliable and efficient methods for exploring research portfolios. In biomedical
Nicolau Duran-Silva, Jorge Carrillo-de-Albornoz, Laura Plaza, Sara Ricardo, Francesco A. Massucci, Sonia Veiga, Arnau Ramos-Prats   +6 more
doaj   +1 more source

Translational Biomedical Informatics and Pharmacometrics Approaches in the Drug Interactions Research [PDF]

CPT: Pharmacometrics & Systems Pharmacology, 2018
Drug interaction is a leading cause of adverse drug events and a major obstacle for current clinical practice. Pharmacovigilance data mining, pharmacokinetic modeling, and text mining are computation and informatic tools on integrating drug interaction knowledge and generating drug interaction hypothesis.
Zhang, Pengyue, Wu, Heng‐Yi, Chiang, Chien‐Wei, Wang, Lei, Binkheder, Samar, Wang, Xueying, Zeng, Donglin, Quinney, Sara K., Li, Lang   +8 more
openaire   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Mapping the evolving definitions of translational research

Journal of Clinical and Translational Science, 2017
Objective Systematic review and analysis of definitions of translational research. Materials and methods The final corpus was comprised of 33 papers, each
Daniel G. Fort, Timothy M. Herr, Pamela L. Shaw, Karen E. Gutzman, Justin B. Starren   +4 more
doaj   +1 more source

2017 Commencement for Sidney Kimmel Medical College, Jefferson Graduate School of Biomedical Sciences, and Jefferson School of Population Health [PDF]

, 2017
Processional Trumpet Voluntary, JOHN STANLEY The Jefferson Processional, BURLE MARX Organist, THE REVEREND R. BRUCE TODD Opening Proclamation RICHARD W. HEVNER, Chair, Board of Trustees, Thomas Jefferson University and Jefferson Health Presentation

core   +4 more sources