Results 141 to 150 of about 396,222 (280)

Variable selection in Logistic regression model with genetic algorithm

, 2018
Variable or feature selection is one of the most important steps in model specification. Especially in the case of medical-decision making, the direct use of a medical database, without a previous analysis and preprocessing step, is often ...
Zhongheng Zhang, Sayed Shahabuddin Hoseini, Subha, Velappan, Victor Trevino, Trevino, Victor, Gorunescu, Florin, Velappan Subha, Boopathi, Arumugam Manivanna, Smaranda Belciug, Arumugam Manivanna Boopathi, Songshi Dai, Hoseini, Sayed Shahabuddin, Dai, Songshi, Ping Zhang, Zhang, Zhongheng, Belciug, Smaranda, Zhang, Ping, Florin Gorunescu   +17 more
core   +1 more source

Conservation of location of several specific inhibitory codon pairs in the Saccharomyces sensu stricto yeasts reveals translational selection. [PDF]

Nucleic Acids Res, 2019
Ghoneim DH, Zhang X, Brule CE, Mathews DH, Grayhack EJ.   +4 more
europepmc   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Implementation of the CDC translational informatics platform - from genetic variants to the national Swedish Rheumatology Quality Register

, 2013
Background Sequencing of the human genome and the subsequent analyses have produced immense volumes of data. The technological advances have opened new windows into genomics beyond the DNA sequence. In parallel, clinical practice generate
Klareskog, Lars, Lars Klareskog, Snir, O, Abugessaisa, I,, Tegner, J,, Lindblad, S,, Malmström, Vivianne, Jesper Tegnér, Klareskog, L,, Gomez-Cabrero, David, Vivianne Malmström, Malmstrom, V, Tegnér, Jesper, Omri Snir, Gomez-Cabrero, D,, David Gomez-Cabrero, Abugessaisa, Imad, Snir, Omri, Imad Abugessaisa, Lindblad, Staffan, Staffan Lindblad   +20 more
core   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Hypervirulent Clostridium difficile ribotypes are CpG depleted

Virulence, 2018
Vinay Kamuju, Santosh Kumar, Wajihul Hasan Khan, Perumal Vivekanandan   +3 more
doaj   +1 more source

Human protein synthesis requires aminoacyl-tRNA pivoting during proofreading

Nature Communications
Rigorous studies have characterized the aa-tRNA selection mechanism in bacteria, which is essential for maintaining translational fidelity. Recent investigations have identified critical distinctions in humans, such as the requirement of subunit rolling ...
Divya Sapkota, Karissa Y. Sanbonmatsu, Dylan Girodat   +2 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source