Results 1 to 10 of about 24,647 (268)

The Sorting Route of Cytochrome b 2Branches from the General Mitochondrial Import Pathway at the Preprotein Translocase of the Inner Membrane* [PDF]

Journal of Biological Chemistry, 1997
Cytochrome b2 is synthesized in the cytosol with a bipartite presequence. The first part of the presequence targets the protein to mitochondria and mediates translocation into the mitochondrial matrix compartment; the second part contains the sorting signal that is required for delivery of the protein to the intermembrane space. The localization of the
U. Bömer, M. Meijer, B. Guiard, K. Dietmeier, N. Pfanner, J. Rassow   +5 more
semanticscholar   +5 more sources

The non-canonical mitochondrial inner membrane presequence translocase of trypanosomatids contains two essential rhomboid-like proteins [PDF]

Nature Communications, 2016
The mitochondrial protein import machinery is crucial for eukaryotes but little is known about its evolutionary origin. Here, the authors characterize the translocase of the inner membrane (TIM) in trypanosomes, showing that it contains two rhomboid-like
Anke Harsman, Silke Oeljeklaus, Christoph Wenger, Jonathan L. Huot, Bettina Warscheid, André Schneider   +5 more
doaj   +5 more sources

The Mitochondrial Translocase of the Inner Membrane PaTim54 is involved in Defense Response and Longevity in Podospora anserina.

Fungal Genetics and Biology, 2019
Fungi are very successful microorganisms capable of colonizing virtually any ecological niche where they must constantly cope with competitors including fungi, bacteria and nematodes.
Alex P. Mercier, Colin Clairet, R. Debuchy, D. Morais, P. Silar, Sylvain Brun   +5 more
semanticscholar   +4 more sources

Evolution of mitochondrial TAT translocases illustrates the loss of bacterial protein transport machines in mitochondria [PDF]

BMC Biology, 2018
Background Bacteria and mitochondria contain translocases that function to transport proteins across or insert proteins into their inner and outer membranes. Extant mitochondria retain some bacterial-derived translocases but have lost others.
Markéta Petrů, Jeremy Wideman, Kristoffer Moore, Felicity Alcock, Tracy Palmer, Pavel Doležal   +5 more
doaj   +4 more sources

Functional Cooperation and Stoichiometry of Protein Translocases of the Outer and Inner Membranes of Mitochondria* [PDF]

Journal of Biological Chemistry, 1997
The qualitative relationship between preprotein translocases in the mitochondrial outer and inner membranes was determined by both a functional analysis and a determination of characteristic components of the translocases.
C. Sirrenberg, Maxi Endres, K. Becker, M. Bauer, Ernst Walther, W. Neupert, M. Brunner   +6 more
semanticscholar   +3 more sources

Differential use of the signal recognition particle translocase targeting pathway for inner membrane protein assembly in Escherichia coli.

Proceedings of the National Academy of Sciences, 1998
Assembly of several inner membrane proteins—leader peptidase (Lep), a Lep derivative (Lep-inv) that inserts with an inverted topology compared with the wild-type protein, the phage M13 procoat protein, and a procoat derivative (H1-procoat) with the hydrophobic core of the signal peptide replaced by a stretch from the first transmembrane ...
J. D. Gier, P. Scotti, Annika Sääf, Q. Valent, A. Kuhn, J. Luirink, G. Heijne   +6 more
semanticscholar   +5 more sources

A unified mechanism for mitochondrial damage sensing in PINK1-Parkin–mediated mitophagy [PDF]

The EMBO Journal
Damaged mitochondria can be cleared from the cell by mitophagy, using a pathway formed by the recessive Parkinson’s disease genes PINK1 and Parkin. Whether the pathway senses diverse forms of mitochondrial damage via a common mechanism, however, remains ...
Julia A Thayer, Jennifer D Petersen, Xiaoping Huang, Luiza M Gruel Budet, James Hawrot, Daniel M Ramos, Shiori Sekine, Yan Li, Michael E Ward, Derek P Narendra   +9 more
doaj   +2 more sources

Correction: Corrigendum: The non-canonical mitochondrial inner membrane presequence translocase of trypanosomatids contains two essential rhomboid-like proteins [PDF]

Nature Communications, 2017
Nature Communications 7: Article number:13707 (2016); Published: 19 December 2016; Updated: 30 June 2017 The original version of this Article contained an error in the gene ID for TimRhom I, cited in the Methods, which specified an unrelated gene.
Anke Harsman, Silke Oeljeklaus, Christoph Wenger, Jonathan L. Huot, Bettina Warscheid, André Schneider   +5 more
doaj   +3 more sources

Organic cation transporter 3 on neuronal mitochondria mediates MPP+-induced mitochondrial dysfunction and neurotoxicity in a TIMM22-dependent manner [PDF]

BMC Biology
Background Mitochondria play crucial roles in cellular metabolism, and metabolite compartmentalization significantly impacts mitochondrial function and disease pathophysiology.
Ao Guan, Sida Han, Suzhen Liang, Weiwei Shen, Min Guo, Mei Cui   +5 more
doaj   +2 more sources

Bacterial porin disrupts mitochondrial membrane potential and sensitizes host cells to apoptosis. [PDF]

PLoS Pathogens, 2009
The bacterial PorB porin, an ATP-binding beta-barrel protein of pathogenic Neisseria gonorrhoeae, triggers host cell apoptosis by an unknown mechanism. PorB is targeted to and imported by host cell mitochondria, causing the breakdown of the mitochondrial
Vera Kozjak-Pavlovic, Elke A Dian-Lothrop, Michael Meinecke, Oliver Kepp, Katharina Ross, Krishnaraj Rajalingam, Anke Harsman, Eva Hauf, Volker Brinkmann, Dirk Günther, Ines Herrmann, Robert Hurwitz, Joachim Rassow, Richard Wagner, Thomas Rudel   +14 more
doaj   +2 more sources