Results 111 to 120 of about 24,647 (268)

MTFP1 is a mitophagy receptor that operates in PINK1/PRKN-dependent mitophagy and promotes oral cancer cell survival

Autophagy Reports, 2023
MTFP1 (mitochondrial fission process 1), an inner mitochondrial membrane protein, plays a crucial role in mitochondrial fission to maintain mitochondrial morphology.
Debasna P Panigrahi, Sujit K Bhutia
doaj   +1 more source

Demonstration of beat‐to‐beat, on‐demand ATP synthesis in ventricular myocytes reveals sex‐specific mitochondrial and cytosolic dynamics

The Journal of Physiology, EarlyView.
Abstract figure legend Beat‐locked mitochondrial ATP transients reveal modular, sex‐specific bioenergetic control during excitation–contraction coupling. A, each action potential activates L‐type CaV1.2 channels, producing a Ca2+ influx that triggers ryanodine receptors (RyR2) and elicits SR Ca2+ release.
Paula Rhana, Collin Matsumoto, L. Fernando Santana   +2 more
wiley   +1 more source

Characterization of Mmp37p, a \u3cem\u3eSaccharomyces cerevisiae\u3c/em\u3e Mitochondrial Matrix Protein with a Role in Mitochondrial Protein Import [PDF]

, 2006
Many mitochondrial proteins are encoded by nuclear genes and after translation in the cytoplasm are imported via translocases in the outer and inner membranes, the TOM and TIM complexes, respectively.
Dienhart, Mary Kathryn, Gallas, Michelle R., Long, Roy M., Stuart, Rosemary A.   +3 more
core   +1 more source

Caspase-2 inhibits mitochondrial respiration in colorectal adenocarcinoma cells

Cell Communication and Signaling
Knockout of caspase-2 in colorectal adenocarcinoma cells enhances mitochondrial oxygen consumption supported by succinate, a substrate of complex II. Additionally, caspase-2 knockout stimulates oxidative stress and promotes cell proliferation.
Chanin Sillapachaiyaporn, Maria A. Yapryntseva, Aygun R. Mamedova, Lina Abdelghany, Vladimir Gogvadze, Boris Zhivotovsky   +5 more
doaj   +1 more source

From the cytosol to the inner membrane: biogenesis of the mitochondrial carrier family

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Mitochondrial carrier proteins are essential for cellular physiology as they are active in a wide range of metabolic pathways including production of cellular energy, amino acid synthesis, redox balance and ion homeostasis. The double membrane of mitochondria provides a tightly gated environment through which carrier proteins facilitate the ...
Catherine S. Palmer, Phoebe J. Leeming, Diana Stojanovski   +2 more
wiley   +1 more source

Uncoupling protein-1 (UCP1) contributes to the basal proton conductance of brown adipose tissue mitochondria [PDF]

, 2009
Proton leak pathways uncouple substrate oxidation from ATP synthesis in mitochondria. These pathways are classified as basal (not regulated) or inducible (activated and inhibited). Previously it was found that over half of the basal proton conductance of
A Andreyev, A Ocloo, AA Toye, AJ Vidal-Puig, Antonio J. Vidal-Puig, B Hojeberg, CY Zhang, D Arsenijevic, D Roussel, DFS Rolfe, DFS Rolfe, DFS Rolfe, DG Nicholls, DG Nicholls, DW Gong, E Rial, E Rial, EN Christiansen, IG Shabalina, IG Shabalina, JA Harper, JA Stuart, KD Garlid, KS Echtay, KS Echtay, LA Sazanov, LN Wu, M Goubern, Martin D. Brand, MD Brand, MD Brand, MD Brand, MD Brand, MM Gonzalez-Barroso, N Parker, N Parker, Nadeene Parker, Paul G. Crichton, RM Locke, S Cadenas, S Enerback, S Monemdjou, TC Esteves, TC Esteves, V Azzu, V Beck, V Beck, VN Samartsev   +47 more
core   +1 more source

High expression of mitochondrial intermembrane chaperone TIMM9 represents a negative prognostic marker in gastric cancer.

Journal of the Formosan Medical Association = Taiwan yi zhi, 2017
BACKGROUND/PURPOSE Gastric cancer (GC) is one of the most common malignant cancers worldwide. However, little is known about the molecular process underlying this disease and its progression. This study investigated correlations between the expression of
C. Lin, C. Fang, Ding-Ping Sun, Y. Hseu, Y. Uen, Kai-Yuan Lin, Yung-Chang Lin   +6 more
semanticscholar   +1 more source

The complexities of respiratory chain biogenesis and maintenance in yeast mitochondria

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Mitochondrial oxidative phosphorylation is the most efficient way of energy conversion for eukaryotic cells. It is executed by a series of high‐molecular weight enzyme complexes in the inner mitochondrial membrane that were acquired during endosymbiosis at the root of eukaryotic evolution.
Andreas Carlström, Carmela Vazquez‐Calvo, Martin Ott   +2 more
wiley   +1 more source

A trypanosomal orthologue of an intermembrane space chaperone has a non-canonical function in biogenesis of the single mitochondrial inner membrane protein translocase

PLOS Pathogens, 2017
Mitochondrial protein import is essential for Trypanosoma brucei across its life cycle and mediated by membrane-embedded heterooligomeric protein complexes, which mainly consist of trypanosomatid-specific subunits. However, trypanosomes contain orthologues of small Tim chaperones that escort hydrophobic proteins across the intermembrane space.
Christoph Wenger, Silke Oeljeklaus, Bettina Warscheid, André Schneider, Anke Harsman   +4 more
openaire   +7 more sources

Visualizing interactions along the Escherichia coli twin-arginine translocation pathway using protein fragment complementation.

PLoS ONE, 2010
The twin-arginine translocation (Tat) pathway is well known for its ability to export fully folded substrate proteins out of the cytoplasm of gram-negative and gram-positive bacteria. Studies of this mechanism in Escherichia coli have identified numerous
Jan S Kostecki, Haiming Li, Raymond J Turner, Matthew P DeLisa   +3 more
doaj   +1 more source