Results 11 to 20 of about 24,647 (268)

Biogenesis of mitochondrial β‐barrel membrane proteins [PDF]

FEBS Open Bio
β‐barrel membrane proteins in the mitochondrial outer membrane are crucial for mediating the metabolite exchange between the cytosol and the mitochondrial intermembrane space. In addition, the β‐barrel membrane protein subunit Tom40 of the translocase of
Iniyan Ganesan, Jon V. Busto, Nikolaus Pfanner, Nils Wiedemann   +3 more
doaj   +2 more sources

Diverse Functions of Tim50, a Component of the Mitochondrial Inner Membrane Protein Translocase [PDF]

International Journal of Molecular Sciences, 2021
Mitochondria are essential in eukaryotes. Besides producing 80% of total cellular ATP, mitochondria are involved in various cellular functions such as apoptosis, inflammation, innate immunity, stress tolerance, and Ca2+ homeostasis. Mitochondria are also the site for many critical metabolic pathways and are integrated into the signaling network to ...
Chaudhuri, Minu, Tripathi, Anuj, Gonzalez, Fidel Soto   +2 more
openaire   +2 more sources

Functions of J-domain proteins in mitochondrial protein biogenesis. [PDF]

Protein Sci
Abstract Mitochondrial biogenesis and functions depend on the import and assembly of more than 1000 proteins that are made as precursors on cytosolic ribosomes. The majority of these precursor proteins are transported from the ribosome to the translocase of the outer membrane (TOM complex), which constitutes the main entry site for mitochondrial ...
Tiku V, Bossenz G, Kirstein J, Becker T.
europepmc   +2 more sources

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

Dimeric SecA couples the preprotein translocation in an asymmetric manner. [PDF]

PLoS ONE, 2011
The Sec translocase mediates the post-translational translocation of a number of preproteins through the inner membrane in bacteria. In the initiatory translocation step, SecB targets the preprotein to the translocase by specific interaction with its ...
Ying Tang, Xijiang Pan, Yong Chen, Phang C Tai, Sen-Fang Sui   +4 more
doaj   +1 more source

Mitochondrial stress in advanced fibrosis and cirrhosis associated with chronic hepatitis B, chronic hepatitis C, or nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...
Dimitri Loureiro, Issam Tout, Stéphanie Narguet, Cheikh Mohamed Bed, Morgane Roinard, Ahmad Sleiman, Nathalie Boyer, Nathalie Pons‐Kerjean, Corinne Castelnau, Nathalie Giuly, Dorothy Tonui, Vassili Soumelis, Jamel El Benna, Patrick Soussan, Richard Moreau, Valérie Paradis, Abdellah Mansouri, Tarik Asselah   +17 more
wiley   +1 more source

Biogenesis of Mitochondrial Metabolite Carriers

Biomolecules, 2020
Metabolite carriers of the mitochondrial inner membrane are crucial for cellular physiology since mitochondria contribute essential metabolic reactions and synthesize the majority of the cellular ATP. Like almost all mitochondrial proteins, carriers have
Patrick Horten, Lilia Colina-Tenorio, Heike Rampelt   +2 more
doaj   +1 more source

A subset of bacterial inner membrane proteins integrated by the twin‐arginine translocase [PDF]

Molecular Microbiology, 2003
Summary A group of bacterial exported proteins are synthesized with N‐terminal signal peptides containing a SRRxFLK ‘twin‐arginine’ amino acid motif. Proteins bearing twin‐arginine signal peptides are targeted post‐translationally to the twin‐arginine translocation (Tat) system which transports folded substrates ...
Hatzixanthis, Kostas, Palmer, Tracy, Sargent, Frank   +2 more
openaire   +3 more sources

Transmembrane Coordination of Preprotein Recognition and Motor Coupling by the Mitochondrial Presequence Receptor Tim50

Cell Reports, 2020
Summary: Mitochondrial preproteins contain amino-terminal presequences directing them to the presequence translocase of the mitochondrial inner membrane (TIM23 complex).
Anne Caumont-Sarcos, Cyril Moulin, Lucyle Poinot, Bernard Guiard, Martin van der Laan, Raffaele Ieva   +5 more
doaj   +1 more source

Prognostic value of TIMM50 expression in colorectal cancer

Archives of Medical Science, 2020
Introduction Translocase of the inner mitochondrial membrane 50 (TIMM50) is universally considered to play a key role in several malignancies. However, its role in predicting colorectal cancer (CRC) patient prognosis remains unclear.
Bo Sun, Jun Wang, Yan-Feng Zhu, Zhen-Yang Li, Jian-Bin Xiang, Zong-You Chen, Zhi-Gang He, Xiao-Dong Gu   +7 more
doaj   +1 more source