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Interaction of presequence with human translocase of the inner membrane of mitochondria Tim50.
The Journal of Physical Chemistry B, 2012The preprotein translocase of the inner membrane of mitochondria (TIM23 complex) is the main entry gate for proteins of the matrix and the inner membrane. Tim50 is a major receptor for transporting the precursor protein across the mitochondrial inner membrane in the TIM23 complex.
Yongqiang Zhang +3 more
semanticscholar +3 more sources
Journal of Experimental Botany, 2023
Abstract The carrier translocase (also known as translocase of the inner membrane 22; TIM22 complex) is an important component of the mitochondrial protein import apparatus. However, the biological functions of AtTIM22-2 in Arabidopsis remain poorly defined.
Yuqin Zhang +6 more
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Abstract The carrier translocase (also known as translocase of the inner membrane 22; TIM22 complex) is an important component of the mitochondrial protein import apparatus. However, the biological functions of AtTIM22-2 in Arabidopsis remain poorly defined.
Yuqin Zhang +6 more
openaire +2 more sources
Genetic and structural characterization of the human mitochondrial inner membrane translocase.
Journal of molecular biology, 1999Translocation of nuclear-encoded mitochondrial preproteins is mediated by translocases in the outer and inner membranes. In the yeast Saccharomyces cerevisiae, translocation of preproteins into the matrix requires the membrane proteins Tim23, Tim17 and Tim44, which drive translocation in cooperation with mtHsp70 and its co-chaperone Mge1p.
M F, Bauer +8 more
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The preprotein translocase of the mitochondrial inner membrane: function and evolution
Journal of Molecular Biology, 1999Growing mitochondria acquire most of their proteins by the uptake of mitochondrial preproteins from the cytosol. To mediate this protein import, both mitochondrial membranes contain independent protein transport systems: the Tom machinery in the outer membrane and the Tim machinery in the inner membrane.
Rassow, Joachim +4 more
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Adenine nucleotide carrier protein dysfunction in human disease
IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology, 2023Adenine nucleotide translocase (ANT) is the prototypical member of the mitochondrial carrier protein family, primarily involved in ADP/ATP exchange across the inner mitochondrial membrane. Several carrier proteins evolutionarily related to ANT, including
Gargi Mishra, L. Coyne, Xin Jie Chen
semanticscholar +1 more source
Journal of Molecular Biology, 1996
The preprotein translocase of the inner mitochondrial membrane has only been described in Saccharomyces cerevisiae to date. We report that the essential subunit Tim17 is highly conserved in evolution. The targeting and assembly of yeast Tim17 as well as that of human and Drosophila melanogaster Tim17 were characterized with isolated yeast mitochondria.
Bomer, U. +5 more
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The preprotein translocase of the inner mitochondrial membrane has only been described in Saccharomyces cerevisiae to date. We report that the essential subunit Tim17 is highly conserved in evolution. The targeting and assembly of yeast Tim17 as well as that of human and Drosophila melanogaster Tim17 were characterized with isolated yeast mitochondria.
Bomer, U. +5 more
openaire +3 more sources
DNA and Cell Biology, 2019
Mitochondria are critical for cellular survival, and for their proper functioning, translocation of ∼1500 proteins across the mitochondrial membranes is required. The translocase of the outer (TOMM) and inner mitochondrial membrane (TIMM) complexes are major components of this translocation machinery.
Thea, Heinemeyer +3 more
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Mitochondria are critical for cellular survival, and for their proper functioning, translocation of ∼1500 proteins across the mitochondrial membranes is required. The translocase of the outer (TOMM) and inner mitochondrial membrane (TIMM) complexes are major components of this translocation machinery.
Thea, Heinemeyer +3 more
openaire +2 more sources
Environmental Microbiology, 2018
Summary Cyanobacteria were the first organisms ever to perform oxygenic photosynthesis and still significantly contribute to primary production on a global scale. To assure the proper functioning of their primary metabolism and cell homeostasis, cyanobacteria must rely on efficient transport systems to cross their
Cátia F. Gonçalves +3 more
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Summary Cyanobacteria were the first organisms ever to perform oxygenic photosynthesis and still significantly contribute to primary production on a global scale. To assure the proper functioning of their primary metabolism and cell homeostasis, cyanobacteria must rely on efficient transport systems to cross their
Cátia F. Gonçalves +3 more
openaire +3 more sources
Protein Expression and Purification, 2012
The preprotein translocase of the inner mitochondrial membrane (TIM23 complex) is the main entry gate for proteins of the matrix and the inner membrane. Tim23 forms a pore for preprotein transportation in TIM23 complex, which spans the inner membrane with transmembrane segments and exposes a hydrophilic domain in the intermembrane space. In this study,
Yongqiang, Zhang +5 more
openaire +2 more sources
The preprotein translocase of the inner mitochondrial membrane (TIM23 complex) is the main entry gate for proteins of the matrix and the inner membrane. Tim23 forms a pore for preprotein transportation in TIM23 complex, which spans the inner membrane with transmembrane segments and exposes a hydrophilic domain in the intermembrane space. In this study,
Yongqiang, Zhang +5 more
openaire +2 more sources