Results 51 to 60 of about 24,647 (268)

Functional Diversity of Human Mitochondrial J-proteins Is Independent of Their Association with the Inner Membrane Presequence Translocase [PDF]

Journal of Biological Chemistry, 2016
Mitochondrial J-proteins play a critical role in governing Hsp70 activity and, hence, are essential for organellar protein translocation and folding. In contrast to yeast, which has a single J-protein Pam18, humans involve two J-proteins, DnaJC15 and DnaJC19, associated with contrasting cellular phenotype, to transport proteins into the mitochondria ...
Devanjan, Sinha, Shubhi, Srivastava, Patrick, D'Silva   +2 more
openaire   +2 more sources

Tim29 is a novel subunit of the human TIM22 translocase and is involved in complex assembly and stability

eLife, 2016
The TIM22 complex mediates the import of hydrophobic carrier proteins into the mitochondrial inner membrane. While the TIM22 machinery has been well characterised in yeast, the human complex remains poorly characterised. Here, we identify Tim29 (C19orf52)
Yilin Kang, Michael James Baker, Michael Liem, Jade Louber, Matthew McKenzie, Ishara Atukorala, Ching-Seng Ang, Shivakumar Keerthikumar, Suresh Mathivanan, Diana Stojanovski   +9 more
doaj   +1 more source

Proteomic and Bioinformatic Profiling of Transporters in Higher Plant Mitochondria

Biomolecules, 2020
To function as a metabolic hub, plant mitochondria have to exchange a wide variety of metabolic intermediates as well as inorganic ions with the cytosol.
Ian Max Møller, R. Shyama Prasad Rao, Yuexu Jiang, Jay J. Thelen, Dong Xu   +4 more
doaj   +1 more source

Mutations in a P-type ATPase gene cause axonal degeneration. [PDF]

PLoS Genetics, 2012
Neuronal loss and axonal degeneration are important pathological features of many neurodegenerative diseases. The molecular mechanisms underlying the majority of axonal degeneration conditions remain unknown.
Xianjun Zhu, Richard T Libby, Wilhelmine N de Vries, Richard S Smith, Dana L Wright, Roderick T Bronson, Kevin L Seburn, Simon W M John   +7 more
doaj   +1 more source

Is the mitochondrion a promising drug target in trypanosomatids?

Memorias do Instituto Oswaldo Cruz, 2022
The trypanosomatids Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp. are etiological agents of important neglected tropical diseases, affecting millions of people worldwide, and the drugs available for these diseases present several limitations.
Yasmin Pedra-Rezende, Ana Cristina Souza Bombaça, Rubem Figueiredo Sadok Menna-Barreto/   +2 more
doaj   +1 more source

Taz1, an outer mitochondrial membrane protein, affects stability and assembly of inner membrane protein complexes: implications for Barth Syndrome.

Molecular Biology of the Cell, 2005
The Saccharomyces cerevisiae Taz1 protein is the orthologue of human Tafazzin, a protein that when inactive causes Barth Syndrome (BTHS), a severe inherited X-linked disease.
Katrin Brandner, David U. Mick, Ann E. Frazier, Rebecca D. Taylor, C. Meisinger, P. Rehling   +5 more
semanticscholar   +1 more source

The Carboxyl-terminal Third of the Dicarboxylate Carrier Is Crucial for Productive Association with the Inner Membrane Twin-pore Translocase [PDF]

Journal of Biological Chemistry, 2005
The carrier proteins of the mitochondrial inner membrane consist of three structurally related tandem repeats (modules). Several different, and in some cases contradictory, views exist on the role individual modules play in carrier transport across the mitochondrial membranes and how they promote protein insertion into the inner membrane.
Brandner, Katrin., Rehling, Peter., Truscott, Kaye N.   +2 more
openaire   +4 more sources

Mutations in valosin-containing protein (VCP) decrease ADP/ATP translocation across the mitochondrial membrane and impair energy metabolism in human neurons [PDF]

, 2017
Mutations in the gene encoding valosin-containing protein (VCP) lead to multisystem proteinopathies including frontotemporal dementia. We have previously shown that patient-derived VCP mutant fibroblasts exhibit lower mitochondrial membrane potential ...
Abramov, Andrey Y. Abramov, Angelova, Bartolome, Bobba, Brand, Brown, Charles Arber, Ding, Edri, Elisavet Preza, Eva Carro, Fernando Bartolome, Ganote, Henry Houlden, Imamura, Johnson, Kokoszka, Krauss, Ludtmann, Macarena de Vicente, Marthe H.R. Ludtmann, Meyer, Muqit, Nalbandian, Nalbandian, Nalbandian, Okita, Papkovskaia, Plun-Favreau, Schirris, Selina Wray, Shi, Shi, Sonia Gandhi, Sposito, Vallier, Vieira, Weihl, Weinbach, Weydt, Wray, Yin, Zhivotovsky   +43 more
core   +2 more sources

High-salinity growth conditions promote tat-independent secretion of tat substrates in Bacillus subtilis [PDF]

, 2012
The Gram-positive bacterium Bacillus subtilis contains two Tat translocases, which can facilitate transport of folded proteins across the plasma membrane. Previous research has shown that Tat-dependent protein secretion in B.
Alami, Antelmann, Antelmann, Barnett, Barnett, Berks, Bogsch, Bolhuis, Bongers, Bron, Bursy, Carmine G. Monteferrante, Chaddock, Cline, Colin Robinson, Cristobal, DeLisa, Driessen, Eijlander, Gasson, Harwood, Hoper, James P. Barnett, Jan Maarten van Dijl, Jongbloed, Jongbloed, Jongbloed, Jongbloed, Kolkman, Kouwen, Kouwen, Kunst, Lewis, Maillard, Meile, Meissner, Mendel, Muller, Natale, Nicolas, Palmer, Palmer, Panahandeh, Pommier, René van der Ploeg, Ridder, Robinson, Robinson, Sambrook, Sargent, Sjouke Piersma, Stanley, Thijs R. H. M. Kouwen, Tjalsma, Tjalsma, Tullman-Ercek, van der Ploeg, van Dijl, van Roosmalen, Yuan   +59 more
core   +1 more source

The protein-conducting channel SecYEG [PDF]

, 2004
In bacteria, the translocase mediates the translocation of proteins into or across the cytosolic membrane. It consists of a membrane embedded protein-conducting channel and a peripherally associated motor domain, the ATPase SecA. The channel is formed by
Driessen, AM, van der Does, C, Veenendaal, AKJ, Veenendaal, Andreas K.J.   +3 more
core   +11 more sources