Results 71 to 80 of about 24,647 (268)

Unique Interactions of the Small Translocases of the Mitochondrial Inner Membrane (Tims) in Trypanosoma brucei

International Journal of Molecular Sciences
The infectious agent for African trypanosomiasis, Trypanosoma brucei, possesses a unique and essential translocase of the mitochondrial inner membrane, known as the TbTIM17 complex. TbTim17 associates with six small TbTims (TbTim9, TbTim10, TbTim11, TbTim12, TbTim13, and TbTim8/13).
Linda S. Quiñones, Fidel Soto Gonzalez, Chauncey Darden, Muhammad Khan, Anuj Tripathi, Joseph T. Smith, Jamaine Davis, Smita Misra, Minu Chaudhuri   +8 more
openaire   +2 more sources

The Metabolic Role of Mitochondria in the Perinatal Cardiac Development and Cardiovascular Diseases

Exploration, EarlyView.
This review explores the critical role of mitochondria in heart development and cardiovascular disease. It highlights how mitochondrial maturation during embryonic‐to‐postnatal transition, regulated by oxygen and metabolic changes, shapes cardiac structure and function.
Minghao Li, Ruiyi Zhang, Xinyuan Li, Hefeng Huang   +3 more
wiley   +1 more source

Preprotein mature domains contain translocase targeting signals that are essential for secretion [PDF]

, 2017
Secretory proteins are only temporary cytoplasmic residents. They are typically synthesized as preproteins, carrying signal peptides N-terminally fused to their mature domains. In bacteria secretion largely occurs posttranslationally through the membrane-
Albert Konijnenberg, Alexandra Tsirigotaki, Anastassios Economou, Bauer, Beckwith, Beerten, Bieker, Blobel, Bradford, Chang, Charalampos G. Kalodimos, Chatzi, Chatzi, Chen, Cunningham, De Geyter, Derman, Dimmer, Frank Sobott, García De La Torre, Gelis, Gouridis, Gouridis, Gouridis, Grudnik, Guex, Hegde, Huang, Hunt, Karamanou, Katerina E. Chatzi, Larkin, Le Loir, Lecker, Lill, Lill, Marina Koukaki, Marios Frantzeskos Sardis, Martoglio, Michaelis, Mitchell, Nikaido, Nikolina Šoštarić, Orfanoudaki, Ortega, Papanikolau, Papanikou, Park, Reineke, Rhoads, Roos, Saio, Schierle, Schneider, Sengoku, Shu, Spyridoula Karamanou, Stoscheck, Testa, Tsirigotaki, Uversky, Wilkins, Wilkins, Zimmer, Zimmer   +64 more
core   +2 more sources

Blood and liver telomere length, mitochondrial DNA copy number, and hepatic gene expression of mitochondrial dynamics in mid-lactation cows supplemented with l-carnitine under systemic inflammation

Journal of Dairy Science, 2023
: The current study was conducted to examine the effect of l-carnitine (LC) supplementation on telomere length and mitochondrial DNA copy number (mtDNAcn) per cell in mid-lactation cows challenged by lipopolysaccharide (LPS) in blood and liver.
S. Häussler, M.H. Ghaffari, K. Seibt, H. Sadri, M. Alaedin, K. Huber, J. Frahm, S. Dänicke, H. Sauerwein   +8 more
doaj   +1 more source

Solute channels of the outer membrane: from bacteria to chloroplasts [PDF]

, 2007
Chloroplasts, unique organelles of plants, originated from endosymbiosis of an ancestor of today's cyanobacteria with a mitochondria-containing host cell. It is assumed that the outer envelope membrane, which delimits the chloroplast from the surrounding
Aljamal J.A., Benz R., Blumenthal A., Drea S.C., Fischer K., Murcha M.W., Pilsl H., Umeda H., Zizi M.   +8 more
core   +1 more source

Mutant huntingtin disrupts mitochondrial proteostasis by interacting with TIM23

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance We delineate the downstream pathologic consequences underlying the known mitochondrial protein import defect caused by mutant huntingtin (mHTT).
S. Yablonska, V. Ganesan, Lisa M. Ferrando, Jinho Kim, Anna M. Pyzel, Oxana V. Baranova, Nicolas K. Khattar, Timothy M. Larkin, S. Baranov, Ning Chen, Colleen E. Strohlein, D. A. Stevens, Xiaomin Wang, Yue-Fang Chang, M. Schurdak, D. Carlisle, J. Minden, R. Friedlander   +17 more
semanticscholar   +1 more source

Identification of Timm13 protein translocase of the mitochondrial inner membrane as a potential mediator of liver fibrosis based on bioinformatics and experimental verification

Journal of Translational Medicine, 2023
Abstract Objective To explore the association between translocase of the inner mitochondrial membrane 13 (Timm13) and liver fibrosis. Methods Gene expression profiles of GSE167033 were collected from Gene Expression Omnibus (GEO).
Xiaomin Liao, Xianxian Ruan, Xianbin Wu, Zhejun Deng, Shanyu Qin, Haixing Jiang   +5 more
openaire   +3 more sources

Effect of crista morphology on mitochondrial ATP output: A computational study

Current Research in Physiology, 2021
Folding of the mitochondrial inner membrane (IM) into cristae greatly increases the ATP-generating surface area, SIM, per unit volume but also creates diffusional bottlenecks that could limit reaction rates inside mitochondria.
Nasrin Afzal, W. Jonathan Lederer, M. Saleet Jafri, Carmen A. Mannella   +3 more
doaj   +1 more source

Oxa1 Directly Interacts with Atp9 and Mediates Its Assembly into the Mitochondrial F\u3csub\u3e1\u3c/sub\u3eF\u3csub\u3eo\u3c/sub\u3e-ATP Synthase Complex [PDF]

, 2007
The yeast Oxa1 protein is involved in the biogenesis of the mitochondrial oxidative phosphorylation (OXPHOS) machinery. The involvement of Oxa1 in the assembly of the cytochrome oxidase (COX) complex, where it facilitates the cotranslational membrane ...
Dienhart, Mary Kathryn, Jia, Lixia, Stuart, Rosemary A.   +2 more
core   +1 more source

Shaping the import system of mitochondria [PDF]

, 2018
Evidence is accumulating that unrelated species have independently evolved the same way of importing proteins in their ...
Alcock, Becker, Dolezal, Gray, Mani, Perry, Riemer, Schmidt, Vitali   +8 more
core   +1 more source