Results 81 to 90 of about 24,647 (268)

Novel IM‐associated protein Tim54 plays a role in the mitochondrial import of internal signal‐containing proteins in Trypanosoma brucei

Biology of the Cell, 2020
The translocase of the mitochondrial inner membrane (TIM) imports most of the nucleus‐encoded proteins that are destined for the matrix, inner membrane (IM) and the intermembrane space (IMS).
U. Singha, A. Tripathi, Joseph T. Smith, L. Quiñones, A. Saha, Tanu Singha, Minu Chaudhuri   +6 more
semanticscholar   +1 more source

A journey along the TIM23 complex, the major protein translocase of the mitochondrial inner membrane

, 2019
Summary. Proper structure and function of mitochondria depends on translocation of over a thousand different mitochondrial proteins from the cytosol. Mitochondrial proteins carry a number of different targeting signals and are translocated into the mitochondria by a number of different protein translocases. Here, we provide an overview of mitochondrial
Günsel, Umut, Mokranjac, Dejana
openaire   +1 more source

Corticosterone and Mitochondrial Efficiency Are Associated With Changes in DNA Oxidative Damage During an Acute Stress Response in Leach's Storm‐Petrels (Hydrobates leucorhous)

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
ABSTRACT The ability of organisms to effectively respond to challenges is critical for survival. We investigated how an acute stressor affected corticosterone, mitochondrial function, and DNA oxidative damage in a wild population of Leach's storm‐petrels (Hydrobates leucorhous).
Kayla E. Lichtner, Jack K. Dziubek, Nicole A. Joseph, Sarah E. Chapman, Tori J. Chace, Dongxiao Sun, Zachary T. Bitzer, Antoine Stier, Robert A. Mauck, Patricia L. Jones, Mark F. Haussmann   +10 more
wiley   +1 more source

Oxidative phosphorylation efficiency, proton conductance and reactive oxygen species production of liver mitochondria correlates with body mass in frogs [PDF]

, 2015
ody size is a central biological parameter affecting most biological processes (especially energetics) and mitochondria is a key organelle controlling metabolism and is also the cell's main source of chemical energy.
Dumet, A., Rey, B., Romestaing, C., Roussel, D., Salin, K., Voituron, Y.   +5 more
core   +3 more sources

The Type III System-Secreted Effector EspZ Localizes to Host Mitochondria and Interacts with the Translocase of Inner Mitochondrial Membrane 17b [PDF]

Infection and Immunity, 2011
ABSTRACT Enteropathogenic and enterohemorrhagic Escherichia coli (EPEC and EHEC, respectively) are attaching and effacing (A/E) bacterial pathogens that cause severe diarrheal disease worldwide. To cause disease, A/E pathogens require a type III secretion system, which facilitates transport of bacterial ...
Stephanie R, Shames, Matthew A, Croxen, Wanyin, Deng, B Brett, Finlay   +3 more
openaire   +2 more sources

Efficacy of omega‐3 fatty acids as a functional food: a multifaceted approach to health reinforcement

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Omega‐3 fatty acids (omega‐3s) are polyunsaturated fatty acids linked with numerous health benefits. Omega‐3s exhibit multifaceted activities through various mechanisms. Eicosapentaenoic acid (EPA) alleviates oxidative stress by lowering reactive oxygen species and improving oxidative stress in brain tissues and acts against neurodegenerative ...
Md Faruque Ahmad, Abdulrahman A Alsayegh, Anjum Khanam, Awais Ahmed, António Raposo, Farkad Bantun, Md Zeyaullah, Ahmad O Babalghith, Abdullah F Aldairi, Boshra Mozaffar, Mohammed F Bajahzer, Mohamed H Abdelrahman, Mohammad Intakhab Alam   +12 more
wiley   +1 more source

A hybrid TIM complex mediates protein import into hydrogenosomes of Trichomonas vaginalis

BMC Biology
Background Hydrogenosomes are a specific type of mitochondria that have adapted for life under anaerobiosis. Limited availability of oxygen has resulted in the loss of the membrane-associated respiratory chain, and consequently in the generation of ...
Abhijith Makki, Sami Kereïche, Tien Le, Jitka Kučerová, Petr Rada, Vojtěch Žárský, Ivan Hrdý, Jan Tachezy   +7 more
doaj   +1 more source

COA6 facilitates cytochrome c oxidase biogenesis as thiol-reductase for copper metallochaperones in mitochondria.

, 2020
The mitochondrial cytochrome c oxidase, the terminal enzyme of the respiratory chain, contains heme and copper centers for electron transfer. The conserved COX2 subunit contains the CuA site, a binuclear copper center.
Aich, A., Bogeski, I., Chacinska, A., Chudenkova, M., Deckers, M., Dennerlein, S., Gibhardt, C., Oeljeklaus, S., Pacheu-Grau, D., Rehling, P., Warscheid, B., Wasilewski, M.   +11 more
core   +2 more sources

Characterization of the Mitochondrial Inner Membrane Translocase Complex: the Tim23p Hydrophobic Domain Interacts with Tim17p but Not with Other Tim23p Molecules [PDF]

Molecular and Cellular Biology, 1998
Tim23p is a mitochondrial inner membrane protein essential for the import of proteins from the cytosol. Tim23p contains an amino-terminal hydrophilic segment and a carboxyl-terminal hydrophobic domain (Tim23Cp). To study the functions and interactions of the two parts of Tim23p separately, we constructed tim23N, encoding only the hydrophilic region of ...
K R, Ryan, R S, Leung, R E, Jensen
openaire   +2 more sources

Mass spectrometry‐based mitochondrial proteomics for cancer biomarker discovery

VIEW, EarlyView.
Figure.1 Schematic diagram of MS‐based mitochondrial proteomics for cancer biomarker discovery. The workflow highlights the integration of advanced technological platforms in mitochondrial proteomics and their application in cancer biomarker discovery.
Zheng Cao, ZiKun Song, Weijie Zhou, Xiaohui Liu, Yanling Liu, Peng R. Chen, Kun Qian   +6 more
wiley   +1 more source