Results 91 to 100 of about 698,201 (312)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Avian Conservation and Ecology, 2022 Survival of translocated prairie-grouse (Tympanuchus spp.) is often low in the first few weeks or months following release into a novel environment. Understanding the processes and mechanisms that influence short-term, post-release survival, such as ...
Steven Roy. Mathews +4 more
doaj
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Future Directions in Sea Otter Research and Management
Frontiers in Marine Science, 2019 The conservation and management of sea otters has benefited from a dedicated research effort over the past 60 years enabling this species to recover from a few thousand in the early 20th century to about 150,000 today.
Randall W. Davis +6 more
doaj +1 more source
Assembly and mechanism of bacterial twin-arginine translocation systems [PDF]
The bacterial twin-arginine translocation (Tat) pathway is able to export pre-folded cofactor containing proteins across the cytoplasmic membrane. Tat substrates bear cleavable N-terminal signal peptides that are characterized by the presence of a ...
Baglieri, J.
core
A dual origin for Bcr-Abl gene translocation/fusion as dynamics of synergism of the hematopoietic stem cell and hemangioblast in chronic myeloid leukemia [PDF]
, 2015 Contextual BCR-ABL tyrosine kinase over-activity determines in formulated fashion the emergence of proliferation and anti-apoptosis that arise largely as derived phenomena of otherwise homeostatic mechanisms of the c-ABL gene within hematopoietic ...
Agius, Lawrence M.
core +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Translocation of Photosynthates in Deciduous Fruit Trees
, 2014 瞭解光合成產物之運移及分配，有助於生產者對作物栽培及生理特性之了解以作正確的管理。落葉果樹光合成產物運移之形式主要為蔗糖及糖醇，運移途徑由供源葉片器官裝載，然後沿韌皮部運移到積貯器官卸載，積貯器官之強度會隨著不同的生育階段而改變。落葉果樹每年出其生長刀比須依看貯藏光合成產物的再轉移，隨著葉片逐漸成熟輸出其光合成產物供應當年的生長與果實之發育，在果實收穫後則運移至貯藏器官。本文亦討論在不同生育階段供源與積貯間關係及其對光合成產物運移之影響。The understanding of ...
Chih-Sheng Chang, 張致盛
core
Translocation of Iron in Podzol Formation
, 1952 Several mechanisms have been postulated to account for the translocation of iron and aluminium in the process of podzol formation. Thus Jones and Willcox1 suggest that simple organic acids such as oxalic acid are responsible for the solution of the ...
Bloomfield, C.
core +1 more source