Results 101 to 110 of about 1,186,405 (387)

Gazing at Translocation in the Mitochondrion [PDF]

Cell, 2008
Most mitochondrial proteins are synthesized in the cytosol and imported into the mitochondrion via molecular machines called translocons on the outer and inner mitochondrial membranes. Alder et al. (2008b) examine protein translocation into intact mitochondria by adapting fluorescent techniques first used to study translocation in the endoplasmic ...
Susan Walsh, Carla M. Koehler
openaire   +3 more sources

A working model for cytoplasmic assembly of H/ACA snoRNPs

FEBS Letters, EarlyView.
Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley   +1 more source

Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death

Cell Research, 2013
Mixed lineage kinase domain-like protein (MLKL) was identified to function downstream of receptor interacting protein 3 (RIP3) in tumor necrosis factor-α (TNF)-induced necrosis (also called necroptosis). However, how MLKL functions to mediate necroptosis
Xin Chen, Wenjuan Li, Junming Ren, Deli Huang, Wan-ting He, Yunlong Song, Chao Yang, Wanyun Li, Xinru Zheng, Pengda Chen, Jiahuai Han   +10 more
semanticscholar   +1 more source

Polymer Translocation througha Pore in a Membrane

, 1998
We construct a new statistical physical model of polymer translocation through a pore in a membrane treated as the diffusion process across a free energy barrier.
Park, P. J., Sung, W.
core   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Unifying model of driven polymer translocation [PDF]

, 2012
We present a Brownian dynamics model of driven polymer translocation, in which non-equilibrium memory effects arising from tension propagation (TP) along the cis side subchain are incorporated as a time-dependent friction. To solve the effective friction,
A. Bhattacharya, B. Alberts, T. Ala-Nissila, T. Ikonen, T. Sakaue, W. Sung   +5 more
core   +3 more sources

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Genetic outcomes from the translocations of the critically endangered woylie

Current Zoology, 2013
Translocations are an important conservation strategy for many species. However simply observing demographic growth of a translocated population is not sufficient to infer species recovery.
Carlo PACIONI, Adrian F.WAYNE, Peter B.S.SPENCER
doaj  

ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

Nature Cell Biology, 2012
Pyruvate kinase M2 (PKM2) is upregulated in multiple cancer types and contributes to the Warburg effect by unclear mechanisms. Here we demonstrate that EGFR-activated ERK2 binds directly to PKM2 Ile 429/Leu 431 through the ERK2 docking groove and ...
Weiwei Yang, Yanhua Zheng, Yan Xia, Haitao Ji, Xiaomin Chen, F. Guo, C. Lyssiotis, K. Aldape, L. Cantley, Zhimin Lu   +9 more
semanticscholar   +1 more source

Directed motion emerging from two coupled random processes: Translocation of a chain through a membrane nanopore driven by binding proteins

, 2005
We investigate the translocation of a stiff polymer consisting of M monomers through a nanopore in a membrane, in the presence of binding particles (chaperones) that bind onto the polymer, and partially prevent backsliding of the polymer through the pore.
Alberts B, Ambjörnsson T, Ambjörnsson T, Bates M, Chauwin J-F, Elston T C, Elston T C, Farkas Z, Gardiner C W, Gerland U, Harada Y, Lubensky D K, McQuistan R B, Meller A, Metzler R, Metzler R, Michael A Lomholt, Peskin C S, Press W H, Ralf Metzler, Risken H, Simon S F, Tobias Ambjörnsson, van Kampen N G   +23 more
core   +2 more sources