Results 101 to 110 of about 1,246,248 (385)

Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death

Cell Research, 2013
Mixed lineage kinase domain-like protein (MLKL) was identified to function downstream of receptor interacting protein 3 (RIP3) in tumor necrosis factor-α (TNF)-induced necrosis (also called necroptosis). However, how MLKL functions to mediate necroptosis
Xin Chen, Wenjuan Li, Junming Ren, Deli Huang, Wan-ting He, Yunlong Song, Chao Yang, Wanyun Li, Xinru Zheng, Pengda Chen, Jiahuai Han   +10 more
semanticscholar   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Comment on ``Passage Times for Unbiased Polymer Translocation through a Narrow Pore'' [PDF]

, 2007
One of the most fundamental quantities associated with polymer translocation through a nanopore is the translocation time $\tau$ and its dependence on the chain length $N$.
Aniket Bhattacharya, Ilkka Huopaniemi, Kaifu Luo, M. Doi, Mikko Karttunen, P. G. de Gennes, Pawel Pomorski, Santtu T. T. Ollila, See-Chen Ying, Tapio Ala-Nissila   +9 more
core   +6 more sources

Translocation of Inhaled Ultrafine Manganese Oxide Particles to the Central Nervous System

Environmental Health Perspectives, 2006
Background Studies in monkeys with intranasally instilled gold ultrafine particles (UFPs; < 100 nm) and in rats with inhaled carbon UFPs suggested that solid UFPs deposited in the nose travel along the olfactory nerve to the olfactory bulb.
A. Elder, R. Gelein, V. Silva, Tessa Feikert, L. Opanashuk, J. Carter, R. Potter, A. Maynard, Yasuo Ito, J. Finkelstein, G. Oberdörster   +10 more
semanticscholar   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Future Directions in Sea Otter Research and Management

Frontiers in Marine Science, 2019
The conservation and management of sea otters has benefited from a dedicated research effort over the past 60 years enabling this species to recover from a few thousand in the early 20th century to about 150,000 today.
Randall W. Davis, James L. Bodkin, Heather A. Coletti, Daniel H. Monson, Shawn E. Larson, Lilian P. Carswell, Linda M. Nichol   +6 more
doaj   +1 more source

Coupled dynamics of RNA folding and nanopore translocation [PDF]

, 2005
The translocation of structured RNA or DNA molecules through narrow pores necessitates the opening of all base pairs. Here, we study the interplay between the dynamics of translocation and base-pairing theoretically, using kinetic Monte Carlo simulations
B. Alberts, C. Gardiner, D. Lubensky, Ralf Bundschuh, Ulrich Gerland   +4 more
core   +2 more sources

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Directed motion emerging from two coupled random processes: Translocation of a chain through a membrane nanopore driven by binding proteins

, 2005
We investigate the translocation of a stiff polymer consisting of M monomers through a nanopore in a membrane, in the presence of binding particles (chaperones) that bind onto the polymer, and partially prevent backsliding of the polymer through the pore.
Alberts B, Ambjörnsson T, Ambjörnsson T, Bates M, Chauwin J-F, Elston T C, Elston T C, Farkas Z, Gardiner C W, Gerland U, Harada Y, Lubensky D K, McQuistan R B, Meller A, Metzler R, Metzler R, Michael A Lomholt, Peskin C S, Press W H, Ralf Metzler, Risken H, Simon S F, Tobias Ambjörnsson, van Kampen N G   +23 more
core   +2 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source