Results 71 to 80 of about 513,979 (295)

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Chaperone driven polymer translocation through Nanopore: spatial distribution and binding energy

, 2016
Chaperones are binding proteins which work as a driving force to bias the biopolymer translocation by binding to it near the pore and preventing its backsliding. Chaperones may have different spatial distribution. Recently we show the importance of their
Abdolvahab, Rouhollah Haji
core   +1 more source

Butyrate protects Caco-2 cells from Campylobacter jejuni invasion and translocation [PDF]

, 2008
Invasion in and translocation across enterocytes are major events during Campylobacter jejuni-induced enteritis in humans. C. jejuni in vitro infection of cell monolayers typically results in loss of tight junction integrity, which could contribute to ...
Ducatelle, Richard, Haesebrouck, Freddy, Pasmans, Frank, Van Deun, Kim, Van Immerseel, Filip   +4 more
core   +1 more source

Translocation and radiotelemetry monitoring of black-tailed marmosets, Callithrix (Mico) melanura(É. Geoffroy in Humboldt), in a wildlife rescue operation in Brazil

Brazilian Journal of Biology
Five black-tailed marmoset Callithrix (Mico) melanura (Primates - Callitrichidae) individuals were monitored by radiotelemetry as part of a project on translocated wildlife affected by flooding the Manso River reservoir in the state of Mato Grosso ...
AAB. Marques, M. Schneider, CJR. Alho
doaj   +1 more source

Diurnal roosts and minimum home range defined by sleeping sites of a thin-spined porcupine Chaetomys subspinosus (Rodentia: Erethizontidae)

Zoologia (Curitiba), 2010
The thin-spined porcupine Chaetomys subspinosus (Olfers, 1818) is a species endemic to the extremely disturbed and fragmented Brazilian Atlantic forest. Little is known about its natural history. We analyzed the preferences of porcupine diurnal roost and
Marlon Zortéa, Bernardo F. A. de Brito
doaj   +1 more source

Flexibility of habitat use in novel environments: insights from a translocation experiment with lesser black-backed gulls [PDF]

Royal Society Open Science, 2017
Being faced with unknown environments is a concomitant challenge of species' range expansions. Strategies to cope with this challenge include the adaptation to local conditions and a flexibility in resource exploitation. The gulls of the Larus argentatus-
Mariëlle L. van Toor, Elena Arriero, Richard A. Holland, Markku J. Huttunen, Risto Juvaste, Inge Müller, Kasper Thorup, Martin Wikelski, Kamran Safi   +8 more
doaj   +1 more source

Brucella NyxA and NyxB dimerization enhances effector function during infection

FEBS Letters, EarlyView.
Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre, Arthur Louche, Francine C. A. Gérard, Laurent Terradot, Suzana P. Salcedo   +4 more
wiley   +1 more source

Translocation of a Single Stranded DNA Through a Conformationally Changing Nanopore [PDF]

, 2004
We investigate the translocation of a single stranded DNA through a pore which fluctuates between two conformations, using coupled master equations.
Alberts, Ambjornsson, Bar-Haim, Bar-Haim, Bates, Berezhkovskii, Chuang, Doering, Doi, Flomenbom, Huang, J. Klafter, Kafri, Kasianowicz, Klafter, Lubensky, Madigan, Meller, Meller, Metzler, Muthukumar, O. Flomenbom, Redner, Slonika, Song, Sung, Zwanzig   +26 more
core   +3 more sources

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Driven translocation of a polymer: role of pore friction and crowding

, 2014
Force-driven translocation of a macromolecule through a nanopore is investigated by taking into account the monomer-pore friction as well as the "crowding" of monomers on the {\it trans} - side of the membrane which counterbalance the driving force ...
Dubbeldam, Johan L. A., Rostiashvili, V. G., Vilgis, T. A.   +2 more
core   +1 more source