Results 91 to 100 of about 659,557 (291)
Tunable Signal Processing Through Modular Control of Transcription Factor Translocation [PDF]
Science, 2013 Transcription Factor as Computer Cellular signaling pathways can serve to process information so that cells respond appropriately to various environmental stimuli. Hao et al. (p.
Nan, Hao +3 more
openaire +2 more sources
Cardiac hypertrophy is inhibited by a local pool of cAMP regulated by phosphodiesterase 2 [PDF]
, 2015 Rationale: Chronic elevation of 3'-5'-cyclic adenosine monophosphate (cAMP) levels has been associated with cardiac remodelling and cardiac hypertrophy.
Aronsen, Jan M. +24 more
core +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Plants, 2020 Metal pollution is pervasive across terrestrial and aquatic ecosystems owing to anthropogenic activities. Sediments can accrue high concentrations of metals and act as secondary sources, and thus may be valuable indicators of metal contamination across ...
Ndivhuwo R. Netshiongolwe +7 more
doaj +1 more source
Biogenesis of mitochondrial porin [PDF]
, 1990 We review here the present knowledge about the pathway of import and assembly of porin into mitochondria and compare it to those of other mitochondrial proteins.
A. Grossmann +74 more
core +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Nuclear Translocation of Apoptosis-Inducing Factor after Focal Cerebral Ischemia [PDF]
Journal of Cerebral Blood Flow & Metabolism, 2004 Signaling cascades associated with apoptosis contribute to cell death after focal cerebral ischemia. Cytochrome c release from mitochondria and the subsequent activation of caspases 9 and 3 are critical steps. Recently, a novel mitochondrial protein, apoptosis-inducing factor (AIF), has been implicated in caspase-independent programmed cell death ...
Nikolaus, Plesnila +5 more
openaire +2 more sources
Crucial role of local peroxynitrite formation in neutrophil-induced endothelial cell activation [PDF]
, 2003 Introduction and methods: The reaction of superoxide anions and NO not only results in a decreased availability of NO, but also leads to the formation of peroxynitrite, the role of which in the cardiovascular system is still discussed controversially. In
Gloe, Torsten +8 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Limnological Review, 2016 The paper concerns the bioaccumulation of zinc, nickel, iron and manganese in leaves and roots of selected macrophytes from the Krzynia Reservoir (northern Poland).
Parzych Agnieszka +2 more
doaj +1 more source