Results 171 to 180 of about 75,114 (212)

An overview of transmissible spongiform encephalopathies

Animal Health Research Reviews, 2004
AbstractTransmissible spongiform encephalopathies (TSEs) are fatal neurodegenerative disorders of humans and animals associated with an accumulation of abnormal isoforms of prion protein (PrP) in nerve cells. The pathogenesis of TSEs involves conformational conversions of normal cellular PrP (PrPc) to abnormal isoforms of PrP (PrPSc). While the protein-
K, Takemura, M, Kahdre, D, Joseph, A, Yousef, S, Sreevatsan   +4 more
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Spiroplasma spp. from transmissible spongiform encephalopathy brains or ticks induce spongiform encephalopathy in ruminants [PDF]

Journal of Medical Microbiology, 2007
Spiroplasma, small motile wall-less bacteria, are linked by molecular and serological studies to the transmissible spongiform encephalopathies (TSEs), which include scrapie in sheep, chronic wasting disease (CWD) in deer and Creutzfeldt-Jakob disease in ...
Frank O Bastian, Joel V Walker, Philip H Elzer   +2 more
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Transmissible spongiform encephalopathies in ruminants

Veterinary Clinics of North America: Food Animal Practice, 2004
Transmissible spongiform encephalopathies (TSEs) have been observed in North American sheep, cervidae, and cattle. The causative agent of TSEs seems to be proteins that induce a conformational change in normal host proteins. Common clinical signs ofTSEs include chronic weight loss and deteriorating neurologic function.
Jeff W, Tyler, John R, Middleton
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Leucodepletion for transmissible spongiform encephalopathies

British Journal of Biomedical Science, 2004
Transmissible spongiform encephalopathies (TSEs) have been recognised around the world for many years. Creutzfeldt-Jakob disease (CJD), one of the human forms of TSE, has been studied widely and thus far has not proved a great threat to human health. The emergence of two new TSEs--bovine spongiform encephalopathy (BSE) in cattle and variant Creutzfeldt-
C, St Romaine, G, Hazlehurst, A P, Jewell   +2 more
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Animal Transmissible Spongiform Encephalopathies and Genetics

Veterinary Research Communications, 2003
The genotype of the host plays a crucial role in the pathogenesis of transmissible spongiform encephalopathies (TSEs). In this respect, the most important factor is represented by the gene of the prion protein (PrP). The present work summarizes the currently available knowledge on the genetic basis of TSEs focusing, in particular, on sheep scrapie ...
AGRIMI U., CONTE M., MORELLI L., DI BARI M. A., DI GUARDO, Giovanni, LIGIOS C., ANTONUCCI G., AUFIERO G. M., POZZATO N., MUTINELLI F., NONNO R., VACCARI G.   +11 more
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The Other Transmissible Spongiform Encephalopathies

Reviews in the Neurosciences, 2005
Murine leukemia viruses may produce encephalopathies that have the same characteristics as those induced by infectious proteins or prions: neuronal loss, astrocytosis, and absence of inflammatory response. The pathogenic mechanism is still poorly understood but it seems that it involves the envelope proteins (Env), which may be misprocessed in the cell,
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Transmissible Spongiform Encephalopathies

Journal of Food Science, 2005
The Institute of Food Technologists has issued this Scientific Status Summary to update our knowledge of transmissible spongiform encephalopathies and provide an authoritative perspective on the surrounding regulatory and trade landscape.
Will Hueston, Cory M. Bryant
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Transmissible Spongiform Encephalopathies

2016
Prion disease is a unique category of illness, affecting both animals and humans, in which the underlying pathogenesis is related to a conformational change of a normal, self-protein called PrPC (C for cellular) to a pathological and infectious conformer known as PrPSc (Sc for scrapie) (Prusiner, Annu Rev Genet 47:601–623, 2013; Aguzzi and Falsig, Nat ...
Thomas Wisniewski, Fernando Goñi
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Reflections on the Transmissible Spongiform Encephalopathies

Veterinary Pathology, 1999
Forty years ago scrapie of sheep and goats was the only known transmissible degenerative disease of the central nervous system. Yet even then its transmissibility was controversial; indeed, its very nature disputed. Nevertheless, at the time, scrapie was unique; no other disease like it had been recognized in man or animals.
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[Transmissible spongiform encephalopathies in animals].

Revista de neurologia, 2000
The transmissible spongiform encephalopathies affect several species of higher animals apart from man. Amongst these, undoubtedly the best known is that affecting cattle, since the association between consumption of beef and its derivatives and the appearance of a variant of Creutzfeldt-Jakob disease in humans has been established.This type of ...
Brun Torres, Alejandro, Castilla, Joaquín, Torres, Juan María   +2 more
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