Results 51 to 60 of about 835,870 (307)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Optimal design scheme based on the segmental transmission line methodology for high-frequency interconnection in 3D micro/nano integration

Nanotechnology and Precision Engineering, 2020
With the continuous growth of signal frequency and package density, discontinuity of the high-frequency interconnection in 3D micro/nano integration becomes unavoidable, which results in serious signal integrity problems.
Chenye Li, Zhensong Li, Min Miao
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Modified Static Hysteresis Simulation Method for Electrical Equipment with Silicon Steel Core

Zhongguo dianli
Compared to traditional hysteresis models like Preisach and Jiles-Atherton (J-A), the micromagnetic Landau-Lifshitz-Gilbert (LLG) equation offers advantages such as clearer physical interpretation and higher simulation accuracy.
Ren LIU, Yu ZENG, Anlong HU, Bo TANG
doaj   +1 more source

A Review of Nonlinear Transmission Line System Design

IEEE Access, 2020
Nonlinear transmission lines (NLTLs) have been increasingly studied to produce high power microwaves (HPM) at higher repetition rates than conventional HPM devices without requiring the same auxiliary systems. The ability to array NLTLs to produce higher
Andrew J. Fairbanks, Adam M. Darr, Allen L. Garner   +2 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

An Integrated Assessment Method for Power System Transient Stability Based on CBAM-ConvGRU [PDF]

Dianli jianshe
[Objective] To improve the effectiveness of transient stability assessment in power systems and address evaluation performance degradation under class-imbalance conditions，this paper proposes an integrated multi-task transient stability assessment method
XU Yanchun, SUN Sihan, ZHANG Jingyu, TANG Xinlin, ZHANG Tao, XI Lei, WANG Lingyun, MI Lu
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Power Quality Estimation in a Remote Wind-Diesel Hybrid Power System in Cartwright, Labrador

Electrica, 2019
Generation of electricity using diesel is costly for small remote isolated communities. At remote location electricity generation from renewable energy such as wind can help reduce the overall operating costs by reducing the fuel costs.
Sheikh Mominul Islam, M. Tariq Iqbal
doaj   +2 more sources