Results 111 to 120 of about 4,157,477 (289)

World Antimalarial Resistance Network (WARN) III: Molecular markers for drug resistant malaria [PDF]

, 2007
Molecular markers for drug resistant malaria represent public health tools of great but mostly unrealized potential value. A key reason for the failure of molecular resistance markers to live up to their potential is that data on the their prevalence is ...
Sibley, CH, Happi Christian T, Mbacham, W, Mugittu, K, Sutherland Colin J, Zimmerman, Peter A., Joshi, HH, Barnwell, JW, Naidoo, I, Happi, Christian T., Sutherland, Colin J, Sibley Carol H, Price Ric N, Mbacham, Wilfred, Happi, Christian T, Rosenthal Philip J, Barnwell, John W., Meshnick, Steven R, Shafer, RW, Plowe, CV, Roper, Cally, Zimmerman, PA, Sibley, Carol Hopkins, Shafer, Robert W, Barnwell John W, Barnwell, John W, Meshnick Steven R, Shafer, Robert W., Naidoo Inbarani, Sibley, Carol H, Joshi, Hema H., Sutherland, CJ, Meshnick, SR, Shafer Robert W, Rosenthal, Phillip J., Happi, CT, Rosenthal, PJ, Plowe Christopher V, Joshi, Hema H, Plowe, Christopher V., Rosenthal, Philip J, Mugittu Kefas, Roper Cally, Meshnick, Steven R., Zimmerman, Peter A, Sutherland, Colin J., Price, Ric N., Plowe, Christopher V, Mugittu, Kefas, Mbacham Wilfred, Naidoo, Inbarani, Price, RN, Price, Ric N, Zimmerman Peter A, Roper, C, Joshi Hema H, Happi, Christian, Zimmerman, Peter   +57 more
core   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Drug-Resistant Tuberculosis Transmission and Resistance Amplification within Families

Emerging Infectious Diseases, 2012
Drug-resistant tuberculosis is caused by transmission of resistant strains of Mycobacterium tuberculosis and by acquisition of resistance through inadequate treatment. We investigated the clinical and molecular features of the disease in 2 families after
James A. Seddon, Rob M. Warren, Donald A. Enarson, Nulda Beyers, H. Simon Schaaf   +4 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Transmitted drug resistance and phylogenetic analysis of HIV CRF01_AE in Northern Vietnam

Infection, Genetics and Evolution, 2012
The HIV epidemic in Vietnam began in injecting drug users (IDUs), but increasingly affects the general population. It is therefore important to monitor the spread of infection and, since antiretroviral therapy (ART) is now used more frequently, the prevalence of transmitted drug resistance.
Bontell, Irene, Cuong, Do Duy, Agneskog, Eva, Diwan, Vinod, Larsson, Mattias, Sönnerborg, Anders   +5 more
openaire   +2 more sources

Frequency of Major Transmitted Integrase Resistance in Poland Remains Low Despite Change in Subtype Variability

Viruses
With the widespread use of integrase inhibitors and the expanding use of long-acting cabotegravir in both pre-exposure prophylaxis and antiretroviral treatment, molecular surveillance on the transmission of integrase resistance has regained clinical ...
Kaja Mielczak, Karol Serwin, Anna Urbańska, Bogusz Aksak-Wąs, Malwina Karasińska-Cieślak, Elżbieta Mularska, Adam Witor, Paweł Jakubowski, Maria Hlebowicz, Monika Bociąga-Jasik, Elżbieta Jabłonowska, Aleksandra Szymczak, Bartosz Szetela, Władysław Łojewski, Miłosz Parczewski   +14 more
doaj   +1 more source

How Much Do We Know about Drug Resistance Due to PrEP Use? Analysis of Experts' Opinion and Its Influence on the Projected Public Health Impact.

PLoS ONE, 2016
BackgroundRandomized controlled trials reported that pre-exposure prophylaxis (PrEP) with tenofovir and emtricitabine rarely selects for drug resistance. However, drug resistance due to PrEP is not completely understood.
Dobromir T Dimitrov, Marie-Claude Boily, Timothy B Hallett, Jan Albert, Charles Boucher, John W Mellors, Deenan Pillay, David A M C van de Vijver   +7 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Application of RNAi to Genomic Drug Target Validation in Schistosomes. [PDF]

, 2015
Concerns over the possibility of resistance developing to praziquantel (PZQ), has stimulated efforts to develop new drugs for schistosomiasis. In addition to the development of improved whole organism screens, the success of RNA interference (RNAi) in ...
Bickle, Quentin D, Bickle, Quentin D., Carruthers, Ian M, Gilbert, Ian H, Ian H Gilbert, Nuha R. Mansour (146895), Andrew L. Hopkins (146939), Jérémy Besnard (741480), Hopkins, Andrew L, Gilbert, Ian H., Guidi, Alessandra, Quentin D. Bickle (146947), Ian H. Gilbert (146934), Alessandra Guidi (146927), Mansour, Nuha R., Paveley, Ross A., Alessandra Guidi, Ross A Paveley, Ian M Carruthers, Carruthers, Ian M., Jérémy Besnard, Quentin D Bickle, Paveley, Ross A, Besnard, Jérémy, Nuha R Mansour, Ross A. Paveley (146889), Mansour, Nuha R, Hopkins, Andrew L., Andrew L Hopkins, Ian M. Carruthers (741479)   +29 more
core   +1 more source