Results 91 to 100 of about 4,157,477 (289)
Transmitted drug resistance in persons with acute/early HIV-1 in San Francisco, 2002-2009. [PDF]
PLoS ONE, 2010 Transmitted HIV-1 drug resistance (TDR) is an ongoing public health problem, representing 10-20% of new HIV infections in many geographic areas. TDR usually arises from two main sources: individuals on antiretroviral therapy (ART) who are failing to ...
Vivek Jain +10 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
The processes of reform in Victoria’s alcohol and other drug sector, 2011-2014 [PDF]
, 2014 This paper explores issues and concerns related to the 2014 alcohol and other drug sector recommissioning process in Victoria. Overview In mid-2014, the Victorian Alcohol and Drug Association approached the Drug Policy Modelling Program, at the ...
Drug Policy Modelling Program
core
Access to art, adherence and drug resistance among HIV-Positive patients in rural Tanzania [PDF]
, 2015 HIV is one of the worst pandemics in recent times, having affected more than 70 million and with a mortality rate close to 50%. Antiretroviral drugs fight viral replication and has improved life of HIV infected patients since it was introduced.
Nyogea, Daniel, Nyogea, Daniel Simon
core +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Transmitted Drug Resistance and HIV Molecular Epidemiology in Nicaragua
Open Forum Infectious Diseases, 2015 Guillermo Porras-Cortes, MD2*; Santiago Avila-Rios, PhD1; Claudia Garcia-Morales, MSc1; Daniela Tapia-Trejo1; Sumaya Moreira-Lopez, MD2; Bismarck Hernandez-Alvarez3; Carlos Quant-Duran, MD2,3*; Gustavo Reyes-Teran, MD1* 1Centre for Research in Infectious Diseases, National Institute of Respiratory Diseases, Mexico City, Mexico.
Santiago Avila-Ríos +7 more
openaire +1 more source
Prevalence of
HIV Medicine, 2017 ObjectivesThe aim of the study was to determine the prevalence of transmitted drug resistance (TDR)‐associated mutations among treatment‐naïve, incarcerated individuals with HIV‐1 infection in the USA as well as the class TDR and antiretroviral (ARV) mutations present at baseline.MethodsPatients over the age of 18 years were included in the study if ...
J, Sapozhnikov +5 more
openaire +2 more sources
PLoS ONE, 2019 BACKGROUND:Tenofovir-containing regimens comprise the preferred first-line antiretroviral therapy (ART) in many countries including South Africa, where utilization of second-line regimens is limited.
Ume L Abbas +3 more
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Post-translational modifications in drug resistance
Resistance to antitumor drugs, antimicrobial drugs, and antiviral drugs severely limits treatment effectiveness and cure rate of diseases. Protein post-translational modifications (PTMs) represented by glycosylation, ubiquitination, SUMOylation ...
Zhang, Cheng +9 more
core +1 more source