Results 71 to 80 of about 79,702 (253)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Transmitted antiretroviral drug resistance surveillance among newly HIV type 1-diagnosed women attending an antenatal clinic in Entebbe, Uganda.

, 2008
To evaluate transmitted HIV-1 drug resistance and study the natural polymorphism in pol of HIV-1 strains of newly diagnosed women attending an antenatal clinic in Uganda we sequenced the protease and reverse transcriptase genes for 46 HIV-1 strains from ...
Kushemererwa, G, Uganda HIV Drug Resistance Working Group, Lyagoba, F, Grosskurth, H, Serwanga, J, Kaleebu, P, Nanteza, B, Katongole-Mbidde, E, Ndembi, N   +8 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Development of an in vitro drug sensitivity assay for Trichuris muris first-stage larvae [PDF]

, 2013
Trichuriasis represents a major public health problem in the developing world and is regarded as a neglected disease. Albendazole and mebendazole, the two drugs of choice against trichuriasis display only moderate cure rates, hence alternative drugs are ...
Jennifer Keiser, Keiser, Jennifer, Tritten, Lucienne, Lucienne Tritten, Wimmersberger, David, David Wimmersberger   +5 more
core   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Impact of Long-Term Treatment with Ivermectin on the Prevalence and Intensity of Soil-Transmitted Helminth Infections

, 2008
Background Control of soil-transmitted helminth (STH) infections relies on the periodic and long-term administration of anthelmintic drugs to high-risk groups, particularly school-age children living in endemic areas.
Oviedo, G, Leila Amorim, Silvia Erazo, Martha Chico, Padilla, M, Gisela Oviedo, Margarita Padilla, Eduardo Gomez, Rodriguez, A, Ana Lucia Moncayo, Alejandro Rodriguez, Raquel Lovato, Lovato, R, Chico, M, Isabel Quinzo, Quinzo, I, Vaca, M, Erazo, S, Amorim, L, Philip J Cooper, Barreto, ML, Maritza Vaca, Mauricio L Barreto, Gomez, E, Moncayo, AL, Cooper, PJ   +25 more
core   +1 more source

Transmitted drug resistance in persons with acute/early HIV-1 in San Francisco, 2002-2009. [PDF]

PLoS ONE, 2010
Transmitted HIV-1 drug resistance (TDR) is an ongoing public health problem, representing 10-20% of new HIV infections in many geographic areas. TDR usually arises from two main sources: individuals on antiretroviral therapy (ART) who are failing to ...
Vivek Jain, Teri Liegler, Eric Vittinghoff, Wendy Hartogensis, Peter Bacchetti, Lauren Poole, Lisa Loeb, Christopher D Pilcher, Robert M Grant, Steven G Deeks, Frederick M Hecht   +10 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Prevalence and incidence of transmitted HIV drug resistance.

, 2019
A: Distribution of transmitted drug resistance by resistance type at 2018 and by 2030. B: Distribution of incident infections by resistance status at 2018 and by 2030.
Yajun Ding (3126264), Gregory Hood (224388), Robert L. Glaubius (6912509), Ume L. Abbas (224384)   +3 more
core   +1 more source

The calibrated population resistance tool: standardized genotypic estimation of transmitted HIV-1 drug resistance. [PDF]

, 2009
UNLABELLED: The calibrated population resistance (CPR) tool is a web-accessible program for performing standardized genotypic estimation of transmitted HIV-1 drug resistance.
Gifford, Robert J, Hue, Stephane, Liu, Tommy F, Rhee, Soo-Yon, Pillay, Deenan, Kiuchi, Mark, Shafer, Robert W   +6 more
core   +1 more source