Results 61 to 70 of about 79,702 (253)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Five Antiretroviral Drug Class–Resistant HIV-1 in a Treatment-Naïve Patient Successfully Suppressed with Optimized Antiretroviral Drug Selection

Journal of the International Association of Providers of AIDS Care, 2015
Transmitted HIV-1 exhibiting reduced susceptibility to protease and reverse transcriptase inhibitors is well documented but limited for integrase inhibitors and enfuvirtide.
Joseph M. Volpe PhD, Douglas J. Ward MD, Laura Napolitano MD, Pham Phung BS, Jonathan Toma BS, Owen Solberg PhD, Christos J. Petropoulos PhD, Charles M. Walworth MD   +7 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

On the pathway to better birth outcomes? A systematic review of azithromycin and curable sexually transmitted infections. [PDF]

, 2013
The WHO recommends the administration of sulfadoxine-pyrimethamine (SP) to all pregnant women living in areas of moderate (stable) to high malaria transmission during scheduled antenatal visits, beginning in the second trimester and continuing to ...
Chandramohan, Daniel, Enesia Ngulube, Chico, R Matthew, Hack, Berkin B, Daniel Chandramohan, Newport, Melanie J, Melanie J Newport, Berkin B Hack, R Matthew Chico, Ngulube, Enesia   +9 more
core   +1 more source

TRANSMITTED DRUG RESISTANCE MUTATIONS AND TRENDS OF HIV-1 SUBTYPES IN TREATMENT-NAÏVE PATIENTS: A SINGLE CENTER EXPERIENCE [PDF]

, 2020
Transmitted drug resistances (TDRs) and HIV-1 diversity could affect treatment efficacy and clinical outcomes. Here we describe the circulating viral subtypes and estimate the prevalence of resistance among drug naïve patients attending Sapienza ...
Cella, Eleonora, Calabretto, Marianna, Iaiani, Giancarlo, Vullo, Vincenzo, Spaziante, Martina, Fimiani, Caterina, Ciccozzi, Massimo, Mezzaroma, Ivano, Turriziani, Ombretta, Falasca, Francesca, Antonelli, Guido, Mazzuti, Laura, Melengu, Taulant, d'Ettorre, Gabriella   +13 more
core   +1 more source

Surveillance of transmitted HIV drug resistance among newly diagnosed, treatment-naive individuals at a county HIV clinic in Santa Clara County

Heliyon, 2019
Introduction: To our knowledge, HIV transmitted drug resistance (TDR) patterns have not been characterized specifically in Santa Clara County (SCC), California, one of the largest counties by population in the United States.
William Chan, Wilson Ly
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Factors associated with different responses to combination antiretroviral therapy in an observational cohort study of HIV-1 infected patients [PDF]

, 2008
The introduction of combination antiretroviral therapy (cART) into clinical practice for the treatment of HIV in 1995-1996 has led to dramatic reductions in mortality and morbidity. Factors linked to a positive response to therapy include a potent and
Bannister, W.P., Bannister, W P
core  

Low-cost ultra-wide genotyping using Roche/454 pyrosequencing for surveillance of HIV drug resistance. [PDF]

PLoS ONE, 2012
Great efforts have been made to increase accessibility of HIV antiretroviral therapy (ART) in low and middle-income countries. The threat of wide-scale emergence of drug resistance could severely hamper ART scale-up efforts. Population-based surveillance
Dawn M Dudley, Emily N Chin, Benjamin N Bimber, Sabri S Sanabani, Leandro F Tarosso, Priscilla R Costa, Mariana M Sauer, Esper G Kallas, David H O'Connor   +8 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source