Results 61 to 70 of about 4,157,477 (289)

Cellular HIV-1 DNA levels in drug sensitive strains are equivalent to those in drug resistant strains in newly-diagnosed patients in Europe. [PDF]

PLoS ONE, 2010
HIV-1 genotypic drug resistance is an important threat to the success of antiretroviral therapy and transmitted resistance has reached 9% prevalence in Europe.
Victoria L Demetriou, David A M C van de Vijver, Ioanna Kousiappa, Claudia Balotta, Bonaventura Clotet, Zehava Grossman, Louise B Jørgensen, Snjezana Z Lepej, Itzchak Levy, Claus Nielsen, Dimitrios Paraskevis, Mario Poljak, Francois Roman, Lidia Ruiz, Jean-Claude Schmidt, Anne-Mieke Vandamme, Anne-Mieke Vandamme, Kristel Van Laethem, Jurgen Vercauteren, Leondios G Kostrikis   +19 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Estimating the prevalence of transmitted HIV drug resistance using pooled samples [PDF]

Statistical Methods in Medical Research, 2013
In many resource-poor countries, hiv-infected patients receive a standardized antiretroviral cocktail. In these settings, population-level surveillance of drug resistance is needed to characterize the prevalence of resistance mutations and to enable antiretroviral therapy programs to select the optimal regimen for their local population.
Mariel M, Finucane, Christopher F, Rowley, Christopher J, Paciorek, Max, Essex, Marcello, Pagano   +4 more
openaire   +2 more sources

HIV and antiretroviral drug resistance

Журнал инфектологии
The article presents modern views on the causes of the formation of drug-resistant HIV strains. The main reasons for the ineffectiveness of antiretroviral therapy are low patient adherence to treatment, lack of combination therapy, and high rate of viral
N. V. Nemchinova, T. A. Bairova, A. Yu. Sambyalova, E. V. Belyaeva, O. A. Ershova   +4 more
doaj   +1 more source

Drug resistant tuberculosis: Implications for transmission, diagnosis, and disease management

Frontiers in Cellular and Infection Microbiology, 2022
Drug resistant tuberculosis contributes significantly to the global burden of antimicrobial resistance, often consuming a large proportion of the healthcare budget and associated resources in many endemic countries.
Dale Liebenberg, Bhavna Gowan Gordhan, Bavesh Davandra Kana   +2 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

VIM-1, VIM-2, and GES-5 Carbapenemases Among Pseudomonas aeruginosa Isolates at a Tertiary Hospital in Istanbul, Turkey. [PDF]

, 2017
Worldwide increase in carbapenem resistance and transferable carbapenemases are significant challenges in treatment of Pseudomonas aeruginosa infections. In this study, investigation of carbapenemase production in carbapenem-resistant P.
Otlu, Barış, Bulut, Mehmet Emin, Aktaş, Elif, Bayraktar, Banu, Malkoçoğlu, Gülşah   +4 more
core   +1 more source

Prevalence and Virologic Consequences of Transmitted HIV-1 Drug Resistance in Uganda [PDF]

AIDS Research and Human Retroviruses, 2014
Few reports have examined the impact of HIV-1 transmitted drug resistance (TDR) in resource-limited settings where there are fewer regimen choices and limited pretherapy/posttherapy resistance testing. In this study, we examined TDR prevalence in Kampala and Mbarara, Uganda and assessed its virologic consequences after ...
Lee, Guinevere Q, Bangsberg, David R, Muzoora, Conrad, Boum, Yap, Oyugi, Jessica H, Emenyonu, Nneka, Bennett, John, Hunt, Peter W, Knapp, David, Brumme, Chanson J, Harrigan, P Richard, Martin, Jeffrey N   +11 more
openaire   +4 more sources

Transmitted Drug Resistance Mutations in Antiretroviral-Naïve Injection Drug Users with Chronic HIV-1 Infection in Iran. [PDF]

PLoS ONE, 2015
The growing incidence and transmission of drug resistant HIV-1 strains due to widespread use of antiretroviral therapy (ART) can jeopardize the success of first-line ART.
Arash Memarnejadian, Shahoo Menbari, Seyed Ali Mansouri, Leila Sadeghi, Rouhollah Vahabpour, Mohammad Reza Aghasadeghi, Ehsan Mostafavi, Mohammad Abdi   +7 more
doaj   +1 more source