Results 41 to 50 of about 4,157,477 (289)

Prevalence and patterns of HIV transmitted drug resistance in Guatemala

Revista Panamericana de Salud Pública, 2011
To assess human immunodeficiency virus (HIV) diversity and the prevalence of transmitted drug resistance (TDR) in Guatemala.One hundred forty-five antiretroviral treatment-naïve patients referred to the Roosevelt Hospital in Guatemala City were enrolled from October 2010 to March 2011.
Santiago, Avila-Ríos, Carlos R, Mejía-Villatoro, Claudia, García-Morales, Maribel, Soto-Nava, Ingrid, Escobar, Ricardo, Mendizabal, Amalia, Girón, Leticia, García, Gustavo, Reyes-Terán   +8 more
openaire   +2 more sources

Spread of anti-malarial drug resistance: mathematical model with implications for ACT drug policies. [PDF]

, 2008
BACKGROUND: Most malaria-endemic countries are implementing a change in anti-malarial drug policy to artemisinin-based combination therapy (ACT). The impact of different drug choices and implementation strategies is uncertain.
Hastings, Ian M, Day, Nicholas PJ, White, Nicholas J., Dondorp, AM, Hastings, Ian M., Dondorp, Arjen M, Dondorp, Adrianus, Hastings, Ian, Day, Nicholas P. J., Pongtavornpinyo, W, Hastings, IM, Pongtavornpinyo, Wirichada, White, Nicholas J, Day, Nicholas, Day, Nicholas P.J., Yeung, Shunmay, Day, NP, White, NJ, White, Nicholas, Dondorp, Arjen M., Yeung, S, Hastings Ian M, Dondorp Arjen M, Pongtavornpinyo Wirichada, Day Nicholas PJ, Yeung Shunmay, White Nicholas J   +26 more
core   +1 more source

An analysis of drug resistance among people living with HIV/AIDS in Shanghai, China.

PLoS ONE, 2017
BackgroundUnderstanding the mechanisms of drug resistance can facilitate better management of antiretroviral therapy, helping to prevent transmission and decrease the morbidity and mortality of people living with HIV/AIDS.
Fengdi Zhang, Li Liu, Meiyan Sun, Jianjun Sun, Hongzhou Lu   +4 more
doaj   +1 more source

Adherence as a predictor of the development of class-specific resistance mutations: the Swiss HIV Cohort Study [PDF]

, 2013
BACKGROUND: Non-adherence is one of the strongest predictors of therapeutic failure in HIV-positive patients. Virologic failure with subsequent emergence of resistance reduces future treatment options and long-term clinical success. METHODS: Prospective
Jürg Böni (36157), Yerly, Sabine, von Wyl Viktor, Alexandra Calmy (36005), Dunja Nicca (336117), Glass, Tracy R, Swiss HIV Cohort Study,, Hansjakob Furrer (93994), Günthard Huldrych F., Vincent Aubert (297526), Jürg Böni, Aubert Vincent, Calmy, Alexandra, Bucher, Heiner C, Huldrych F. Günthard (173082), Böni, J., Cavassini Matthias, Viktor von Wyl, Swiss HIV Cohort Study, Günthard, Huldrych F., Enos Bernasconi (174329), Furrer, Hansjakob, Heiner C Bucher, Klimkait, Thomas, Hansjakob Furrer, Alexandra Calmy, Calmy Alexandra, Aubert, Vincent, Glass, T.R., Sabine Yerly (82534), Dunja Nicca, Yerly, S., Bucher, Heiner C., Tracy R. Glass (134725), Yerly Ferrillo, Sabine, Bucher Heiner C., Tracy R Glass, Nicca, D., Bernasconi, E., Wainberg, Mark, Thomas Klimkait (178911), Calmy, A., Günthard, Huldrych F, Enos Bernasconi, Heiner C. Bucher (134728), Cavassini, M., Matthias Cavassini (146654), Aubert, V., Glass, Tracy R., Böni, Jürg, Klimkait Thomas, Thomas Klimkait, Glass Tracy R., Bernasconi, Enos, Nicca Dunja, von Wyl, Viktor, Nicca, Dunja, von Wyl, V., Furrer Hansjakob, Bernasconi Enos, Sabine Yerly, Furrer, H., Viktor von Wyl (146506), Günthard, H.F., Böni Jürg, Klimkait, T., Yerly Sabine, Vincent Aubert, Bucher, H.C., Huldrych F Günthard, Cavassini, Matthias, Matthias Cavassini   +71 more
core   +3 more sources

Transmission and prevalence of drug-resistant tuberculosis in a Brazilian setting under a directly observed therapy short-course strategy

Revista da Sociedade Brasileira de Medicina Tropical, 2020
INTRODUCTION: We aimed to estimate the prevalence and transmission of drug-resistant tuberculosis in a high-burden Brazilian setting under directly observed therapy short-course strategy.
Fábio Oliveira Latrilha, Vera Simonsen, Juliana Maira Watanabe Pinhata, Angela Pires Brandão, Vera Maria Neder Galesi, Eliseu Alves Waldman, Lucilaine Ferrazoli   +6 more
doaj   +1 more source

Acquired and Transmitted Multidrug Resistant Tuberculosis: The Role of Social Determinants. [PDF]

PLoS ONE, 2016
Although risk factors for multi-drug resistant tuberculosis are known, few studies have differentiated between acquired and transmitted resistance.
Anna Odone, Roger Calderon, Mercedes C Becerra, Zibiao Zhang, Carmen C Contreras, Rosa Yataco, Jerome Galea, Leonid Lecca, Matthew H Bonds, Carole D Mitnick, Megan B Murray   +10 more
doaj   +1 more source

Analysis of transmitted HIV-1 drug resistance using 454 ultra-deep-sequencing and the DeepChek(®)-HIV system. [PDF]

, 2014
Introduction Next-generation sequencing (NGS) is capable of detecting resistance-associated mutations (RAMs) present at frequencies of 1% or below. Several studies have found that baseline low-frequency RAMs are associated with failure to first-line ...
Gonzalez, D., Garcia-Diaz, A., Webster, D., Johnson, M., Sayada, C., Haque, T., McCormick, A.L., Booth, C.   +7 more
core   +1 more source

High viremia and low level of transmitted drug resistance in anti-retroviral therapy-naïve perinatally-infected children and adolescents with HIV-1 subtype C infection

BMC Infectious Diseases, 2012
Background High plasma viremia in HIV-1 infection is associated with rapid CD4 cell decline and faster disease progression. Children with HIV infection have high viral loads, particularly in early childhood.
Neogi Ujjwal, Sahoo Pravat Nalini, De Costa Ayesha, Shet Anita   +3 more
doaj   +1 more source

Nitroheterocyclic drug resistance mechanisms in Trypanosoma brucei [PDF]

, 2016
Objectives The objective of this study was to identify the mechanisms of resistance to nifurtimox and fexinidazole in African trypanosomes. Methods Bloodstream-form Trypanosoma brucei were selected for resistance to nifurtimox and fexinidazole by ...
Kelner, Anna, Fairlamb, Alan; id_orcid, Berriman, Matthew, Foth, Bernado J., Sokolova, Antoaneta Y., Wyllie, Susan   +5 more
core   +1 more source

Comparison of algorithms that interpret genotypic HIV-1 drug resistance to determine the prevalence of transmitted drug resistance [PDF]

AIDS, 2008
We compared eight genotypic interpretation methods to determine whether the method used would affect the rates of reported transmitted drug resistance.Retrospective cohort study.For the International AIDS Society-USA method we classified a mutation as resistant if it was a 'major' resistance-associated mutation.
Lin, Liu, Susanne, May, Douglas D, Richman, Frederick M, Hecht, Martin, Markowitz, Eric S, Daar, Jean-Pierre, Routy, Joseph B, Margolick, Ann C, Collier, Christopher H, Woelk, Susan J, Little, Davey M, Smith   +11 more
openaire   +3 more sources