Results 41 to 50 of about 79,702 (253)

National prevalence and trends of HIV transmitted drug resistance in Mexico. [PDF]

PLoS ONE, 2011
BACKGROUND: Transmitted drug resistance (TDR) remains an important concern for the management of HIV infection, especially in countries that have recently scaled-up antiretroviral treatment (ART) access.
Santiago Avila-Ríos, Claudia García-Morales, Daniela Garrido-Rodríguez, Christopher E Ormsby, Ramón Hernández-Juan, Jaime Andrade-Villanueva, Luz A González-Hernández, Indiana Torres-Escobar, Samuel Navarro-Álvarez, Gustavo Reyes-Terán, Mexican HIV Molecular Epidemiology Project Group   +10 more
doaj   +1 more source

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

The role of the HIV-1 protease substrate in therapy resistance [PDF]

, 2015
In Switzerland and Germany up to a half of the first-line regimens include protease inhibitors (PIs) [1, 2]. Although in the Swiss HIV Cohort Study (SHCS) most patients under antiretroviral therapy (ART) have suppressed viral loads [3], every third ...
Kletenkov, Konstantin
core   +1 more source

Hospitalization Through Families’ Eyes: Comparing Inpatient Care Quality for Children With Sickle Cell Disease and Cystic Fibrosis in Canada

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a chronic, inherited hemoglobinopathy that requires frequent hospitalization for disease‐related complications. Canadian data on inpatient care is limited. This study compared caregiver‐reported hospital experiences of children with SCD to those with cystic fibrosis (CF), a chronic, autosomal recessive ...
Hailey M. Zwicker, Kyle Kemp, Perri Tutelman, Sharon H. J. Hou, Paul Fairie, Maria Santana, Gregory M. T. Guilcher, Taryn Fay‐McClymont, Glenda Bendiak, Wendy Pelletier, Nicola Wright, Fiona Schulte   +11 more
wiley   +1 more source

HIV and antiretroviral drug resistance

Журнал инфектологии
The article presents modern views on the causes of the formation of drug-resistant HIV strains. The main reasons for the ineffectiveness of antiretroviral therapy are low patient adherence to treatment, lack of combination therapy, and high rate of viral
N. V. Nemchinova, T. A. Bairova, A. Yu. Sambyalova, E. V. Belyaeva, O. A. Ershova   +4 more
doaj   +1 more source

Prevalence of transmitted drug resistance and impact of transmitted resistance on treatment success in the German HIV-1 Seroconverter Cohort.

PLoS ONE, 2010
BackgroundThe aim of this study is to analyse the prevalence of transmitted drug resistance, TDR, and the impact of TDR on treatment success in the German HIV-1 Seroconverter Cohort.MethodsGenotypic resistance analysis was performed in treatment-naïve ...
Barbara Bartmeyer, Claudia Kuecherer, Claudia Houareau, Johanna Werning, Kathrin Keeren, Sybille Somogyi, Christian Kollan, Heiko Jessen, Stephan Dupke, Osamah Hamouda, German HIV-1 Seroconverter Study Group   +10 more
doaj   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Evolution of transmitted HIV-1 drug resistance in HIV-1 infected patients in Italy from 2000 to 2010. [PDF]

, 2012
Prevalence and predictors of transmitted drug resistance (TDR), defined as the presence of at least one WHO surveillance drug resistance mutation (SDRM), were investigated in antiretroviral-naive HIV-1-infected patients, with a genotypic resistance test (
Torti, C., Cauda, R., Giambenedetto, A., Corsi, P., Parruti, G., Penco, G., Monno, L., Bruzzone, B., Gonnelli, A., FILICE, GAETANO, Arca, Ucsc And Brescia Hiv Resistance Study G. R. O. U. P. S., Bagnarelli, P., Albini, L., Punzi, G., Rosi, A., Micheli, V., Colafigli, M., Manca, N., Trecarichi E. , M.   +18 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Cellular HIV-1 DNA levels in drug sensitive strains are equivalent to those in drug resistant strains in newly-diagnosed patients in Europe. [PDF]

PLoS ONE, 2010
HIV-1 genotypic drug resistance is an important threat to the success of antiretroviral therapy and transmitted resistance has reached 9% prevalence in Europe.
Victoria L Demetriou, David A M C van de Vijver, Ioanna Kousiappa, Claudia Balotta, Bonaventura Clotet, Zehava Grossman, Louise B Jørgensen, Snjezana Z Lepej, Itzchak Levy, Claus Nielsen, Dimitrios Paraskevis, Mario Poljak, Francois Roman, Lidia Ruiz, Jean-Claude Schmidt, Anne-Mieke Vandamme, Anne-Mieke Vandamme, Kristel Van Laethem, Jurgen Vercauteren, Leondios G Kostrikis   +19 more
doaj   +1 more source