Results 31 to 40 of about 79,702 (253)

Transmission and prevalence of drug-resistant tuberculosis in a Brazilian setting under a directly observed therapy short-course strategy

Revista da Sociedade Brasileira de Medicina Tropical, 2020
INTRODUCTION: We aimed to estimate the prevalence and transmission of drug-resistant tuberculosis in a high-burden Brazilian setting under directly observed therapy short-course strategy.
Fábio Oliveira Latrilha, Vera Simonsen, Juliana Maira Watanabe Pinhata, Angela Pires Brandão, Vera Maria Neder Galesi, Eliseu Alves Waldman, Lucilaine Ferrazoli   +6 more
doaj   +1 more source

Acquired and Transmitted Multidrug Resistant Tuberculosis: The Role of Social Determinants. [PDF]

PLoS ONE, 2016
Although risk factors for multi-drug resistant tuberculosis are known, few studies have differentiated between acquired and transmitted resistance.
Anna Odone, Roger Calderon, Mercedes C Becerra, Zibiao Zhang, Carmen C Contreras, Rosa Yataco, Jerome Galea, Leonid Lecca, Matthew H Bonds, Carole D Mitnick, Megan B Murray   +10 more
doaj   +1 more source

High viremia and low level of transmitted drug resistance in anti-retroviral therapy-naïve perinatally-infected children and adolescents with HIV-1 subtype C infection

BMC Infectious Diseases, 2012
Background High plasma viremia in HIV-1 infection is associated with rapid CD4 cell decline and faster disease progression. Children with HIV infection have high viral loads, particularly in early childhood.
Neogi Ujjwal, Sahoo Pravat Nalini, De Costa Ayesha, Shet Anita   +3 more
doaj   +1 more source

Access to art, adherence and drug resistance among HIV-Positive patients in rural Tanzania [PDF]

, 2015
HIV is one of the worst pandemics in recent times, having affected more than 70 million and with a mortality rate close to 50%. Antiretroviral drugs fight viral replication and has improved life of HIV infected patients since it was introduced.
Nyogea, Daniel, Nyogea, Daniel Simon
core   +1 more source

Activity of oxantel pamoate monotherapy and combination chemotherapy against Trichuris muris and hookworms : revival of an old drug [PDF]

, 2013
BACKGROUND: It is widely recognized that only a handful of drugs are available against soil-transmitted helminthiasis, all of which are characterized by a low efficacy against Trichuris trichiura, when administered as single doses.
Speich Benjamin, Tritten Lucienne, Jennifer Keiser, Speich, B., Keiser Jennifer, Benjamin Speich, Adelfio Roberto, Keiser, J., Adelfio, R., Tritten, L., Silbereisen Angelika, Vargas Mireille, Angelika Silbereisen, Roberto Adelfio, Silbereisen, A., Vargas, M., Lucienne Tritten, Mireille Vargas   +17 more
core   +1 more source

Prevalence and trends in transmitted and acquired antiretroviral drug resistance, Washington, DC, 1999–2014

BMC Research Notes, 2017
Background Drug resistance limits options for antiretroviral therapy (ART) and results in poorer health outcomes among HIV-infected persons. We sought to characterize resistance patterns and to identify predictors of resistance in Washington, DC. Methods
Annette M. Aldous, Amanda D. Castel, David M. Parenti, the DC Cohort Executive Committee   +3 more
doaj   +1 more source

Novel insights in the fecal egg count reduction test for monitoring drug efficacy against soil-transmitted helminths in large-scale treatment programs

, 2011
Background The fecal egg count reduction test (FECRT) is recommended to monitor drug efficacy against soil-transmitted helminths (STHs) in public health.
Robert J. Dobson, Charlier, Johannes, Jozef Vercruysse, Speybroeck, Niko, Levecke Bruno, Charlier Johannes, Dobson, Robert J, Dobson, R.J., Charlier, J., Vercruysse, J., Johannes Charlier, Vercruysse Jozef, Bruno Levecke, Niko Speybroeck, Speybroeck, N., Vercruysse, Jozef, Levecke, B., Dobson Robert J., Levecke, Bruno, Robert J Dobson, Speybroeck Niko   +20 more
core   +1 more source

Antiretroviral Treatment Simplification With 2-Drug Regimens: Impact of Transmitted Drug Resistance Mutations. [PDF]

Open Forum Infect Dis, 2020
The frequency of clinically relevant transmitted drug resistance mutations (DRMs) against drugs used for 2-drug regimens was 15.6%, but only 2% were not eligible for 1 or more 2-drug regimens.
Kessler HH, Stelzl E, Blažič A, Mehta SR, Benezeder AS, Genger-Hackl C, Santner BI, Chaillon A, Hoenigl M.   +8 more
europepmc   +2 more sources

Application of RNAi to Genomic Drug Target Validation in Schistosomes. [PDF]

, 2015
Concerns over the possibility of resistance developing to praziquantel (PZQ), has stimulated efforts to develop new drugs for schistosomiasis. In addition to the development of improved whole organism screens, the success of RNA interference (RNAi) in ...
Bickle, Quentin D, Bickle, Quentin D., Carruthers, Ian M, Gilbert, Ian H, Ian H Gilbert, Nuha R. Mansour (146895), Andrew L. Hopkins (146939), Jérémy Besnard (741480), Hopkins, Andrew L, Gilbert, Ian H., Guidi, Alessandra, Quentin D. Bickle (146947), Ian H. Gilbert (146934), Alessandra Guidi (146927), Mansour, Nuha R., Paveley, Ross A., Alessandra Guidi, Ross A Paveley, Ian M Carruthers, Carruthers, Ian M., Jérémy Besnard, Quentin D Bickle, Paveley, Ross A, Besnard, Jérémy, Nuha R Mansour, Ross A. Paveley (146889), Mansour, Nuha R, Hopkins, Andrew L., Andrew L Hopkins, Ian M. Carruthers (741479)   +29 more
core   +1 more source

Epidemic Characteristics of HIV Drug Resistance in Hefei, Anhui Province

Pathogens, 2022
To study the characteristics of HIV pretreatment drug resistance (PDR) and acquired drug resistance (ADR) in Hefei, a cross-sectional survey was used to collect 816 samples from newly reported HIV infections from 2017 to 2020 and 127 samples from HIV ...
Shan Zheng, Jianjun Wu, Jingjing Hao, Dong Wang, Zhongwang Hu, Lei Liu, Chang Song, Jing Hu, Yanhua Lei, Hai Wang, Lingjie Liao, Yi Feng, Yiming Shao, Yuhua Ruan, Hui Xing   +14 more
doaj   +1 more source