Explaining risk factors for drug-resistant tuberculosis in England and Wales: contribution of primary and secondary drug resistance [PDF]
, 2004 Drug-resistant tuberculosis can be transmitted (primary) or develop during the course of treatment (secondary). We investigated risk factors for each type of resistance.
Glynn, JR +5 more
core +1 more source
The effect of intrinsic stochasticity on transmitted HIV drug resistance patterns [PDF]
Journal of Theoretical Biology, 2010 Estimates of transmitted HIV drug-resistance prevalence vary widely among and within epidemiological surveys. Interpretation of trends from available survey data is therefore difficult. Because the emergence of drug-resistance involves small populations of infected drug-resistant individuals, the role of stochasticity (chance events) is likely to be ...
Marks, A, Pillay, D, Mclean, A
openaire +2 more sources
Molecular monitoring of HIV-1 drug resistance in Ifakara HIV-1 Cohort, Tanzania [PDF]
, 2013 HIV-1 resistance is one of the problems affecting success of antiretroviral therapy programmes worldwide. Many studies on efficacy of ART programmes, specifically on drug resistance, have been conducted in developed countries but not in developing ...
Masimba, Pax Jessey
core +1 more source
Evolution of primary HIV drug resistance in a subtype C dominated epidemic in Mozambique. [PDF]
PLoS ONE, 2013 In Mozambique, highly active antiretroviral treatment (HAART) was introduced in 2004 followed by decentralization and expansion, resulting in a more than 20-fold increase in coverage by 2009. Implementation of HIV drug resistance threshold surveys (HIVDR-
Dulce Celina Adolfo Bila +10 more
doaj +1 more source
HIV transmitted drug resistance in adult and pediatric populations in Panama [PDF]
Revista Panamericana de Salud Pública, 2011 To investigate the prevalence of transmitted drug-resistant HIV among adults in Panama by using a modified World Health Organization Threshold Survey (WHO-TS) and to investigate rates of initial resistance among HIV-positive infants in Panama.At the Gorgas Memorial Institute, 47 HIV-positive adults were genotyped for mutations associated with ...
Juan, Castillo +9 more
openaire +2 more sources
Sentinel surveillance of HIV-1 transmitted drug resistance, acute infection and recent infection. [PDF]
PLoS ONE, 2011 HIV-1 acute infection, recent infection and transmitted drug resistance screening was integrated into voluntary HIV counseling and testing (VCT) services to enhance the existing surveillance program in San Francisco.
Hong-Ha M Truong +6 more
doaj +1 more source
Transmitted Drug Resistance in Nonsubtype B HIV-1 Infection [PDF]
HIV Therapy, 2009 HIV-1 nonsubtype B variants account for the majority of HIV infections worldwide. Drug resistance in individuals who have never undergone antiretroviral therapy can lead to early failure and limited treatment options and, therefore, is an important concern.
Philip A, Chan, Rami, Kantor
openaire +2 more sources
Drug resistance with monitored adherence [PDF]
, 2013 Drug resistance can be defined as the failure of a drug to exert its expected effect on pharmacological biomarkers and is caused by pharmacogenetic, cellular or clinical factors.
Walter, Philipp Niklaus
core +1 more source
Antiretroviral Treatment Simplification With 2-Drug Regimens: Impact of Transmitted Drug Resistance Mutations. [PDF]
Open Forum Infect Dis, 2020 Abstract The frequency of clinically relevant transmitted drug resistance mutations (DRMs) against drugs used for 2-drug regimens was 15.6%, but only 2% were not eligible for 1 or more 2-drug regimens. More than 50% of patients harboring any clinically relevant DRMs were found to be part of genetic transmission clusters.
Kessler HH +8 more
europepmc +5 more sources
Hsp90 governs dispersion and drug resistance of fungal biofilms [PDF]
, 2011 Fungal biofilms are a major cause of human mortality and are recalcitrant to most treatments due to intrinsic drug resistance. These complex communities of multiple cell types form on indwelling medical devices and their eradication often requires ...
Ramage Gordon +25 more
core +2 more sources