Results 31 to 40 of about 76,872 (109)

HIV and antiretroviral drug resistance

Журнал инфектологии
The article presents modern views on the causes of the formation of drug-resistant HIV strains. The main reasons for the ineffectiveness of antiretroviral therapy are low patient adherence to treatment, lack of combination therapy, and high rate of viral
N. V. Nemchinova, T. A. Bairova, A. Yu. Sambyalova, E. V. Belyaeva, O. A. Ershova   +4 more
doaj   +1 more source

Drug resistant tuberculosis: Implications for transmission, diagnosis, and disease management

Frontiers in Cellular and Infection Microbiology, 2022
Drug resistant tuberculosis contributes significantly to the global burden of antimicrobial resistance, often consuming a large proportion of the healthcare budget and associated resources in many endemic countries.
Dale Liebenberg, Bhavna Gowan Gordhan, Bavesh Davandra Kana   +2 more
doaj   +1 more source

Transmitted Drug Resistance Mutations in Antiretroviral-Naïve Injection Drug Users with Chronic HIV-1 Infection in Iran. [PDF]

PLoS ONE, 2015
The growing incidence and transmission of drug resistant HIV-1 strains due to widespread use of antiretroviral therapy (ART) can jeopardize the success of first-line ART.
Arash Memarnejadian, Shahoo Menbari, Seyed Ali Mansouri, Leila Sadeghi, Rouhollah Vahabpour, Mohammad Reza Aghasadeghi, Ehsan Mostafavi, Mohammad Abdi   +7 more
doaj   +1 more source

Modeling Drug Resistance Emergence and Transmission in HIV-1 in the UK

Viruses, 2023
A deeper understanding of HIV-1 transmission and drug resistance mechanisms can lead to improvements in current treatment policies. However, the rates at which HIV-1 drug resistance mutations (DRMs) are acquired and which transmitted DRMs persist are ...
Anna Zhukova, David Dunn, Olivier Gascuel   +2 more
doaj   +1 more source

The prevalence of drug resistance among treatment-naïve HIV-1-infected individuals in China during pre- and post- 2004

BMC Infectious Diseases, 2016
Background The widespread use of antiretroviral therapies has led to considerable concerns about the prevalence of drug-resistant, as transmission of drug-resistant (TDR) strains poses a challenge for the control of the HIV-1 epidemic.
Hanping Li, Shuai Chang, Yang Han, Daomin Zhuang, Lin Li, Yongjian Liu, Siyang Liu, Zuoyi Bao, Wenfu Zhang, Hongbin Song, Taisheng Li, Jingyun Li   +11 more
doaj   +1 more source

Five Antiretroviral Drug Class–Resistant HIV-1 in a Treatment-Naïve Patient Successfully Suppressed with Optimized Antiretroviral Drug Selection

Journal of the International Association of Providers of AIDS Care, 2015
Transmitted HIV-1 exhibiting reduced susceptibility to protease and reverse transcriptase inhibitors is well documented but limited for integrase inhibitors and enfuvirtide.
Joseph M. Volpe PhD, Douglas J. Ward MD, Laura Napolitano MD, Pham Phung BS, Jonathan Toma BS, Owen Solberg PhD, Christos J. Petropoulos PhD, Charles M. Walworth MD   +7 more
doaj   +1 more source

Surveillance of transmitted HIV drug resistance among newly diagnosed, treatment-naive individuals at a county HIV clinic in Santa Clara County

Heliyon, 2019
Introduction: To our knowledge, HIV transmitted drug resistance (TDR) patterns have not been characterized specifically in Santa Clara County (SCC), California, one of the largest counties by population in the United States.
William Chan, Wilson Ly
doaj   +1 more source

Low-cost ultra-wide genotyping using Roche/454 pyrosequencing for surveillance of HIV drug resistance. [PDF]

PLoS ONE, 2012
Great efforts have been made to increase accessibility of HIV antiretroviral therapy (ART) in low and middle-income countries. The threat of wide-scale emergence of drug resistance could severely hamper ART scale-up efforts. Population-based surveillance
Dawn M Dudley, Emily N Chin, Benjamin N Bimber, Sabri S Sanabani, Leandro F Tarosso, Priscilla R Costa, Mariana M Sauer, Esper G Kallas, David H O'Connor   +8 more
doaj   +1 more source

Transmitted drug resistance in persons with acute/early HIV-1 in San Francisco, 2002-2009. [PDF]

PLoS ONE, 2010
Transmitted HIV-1 drug resistance (TDR) is an ongoing public health problem, representing 10-20% of new HIV infections in many geographic areas. TDR usually arises from two main sources: individuals on antiretroviral therapy (ART) who are failing to ...
Vivek Jain, Teri Liegler, Eric Vittinghoff, Wendy Hartogensis, Peter Bacchetti, Lauren Poole, Lisa Loeb, Christopher D Pilcher, Robert M Grant, Steven G Deeks, Frederick M Hecht   +10 more
doaj   +1 more source

Drug resistance from preferred antiretroviral regimens for HIV infection in South Africa: A modeling study.

PLoS ONE, 2019
BACKGROUND:Tenofovir-containing regimens comprise the preferred first-line antiretroviral therapy (ART) in many countries including South Africa, where utilization of second-line regimens is limited.
Ume L Abbas, Robert L Glaubius, Yajun Ding, Gregory Hood   +3 more
doaj   +1 more source