Results 51 to 60 of about 4,157,477 (289)

Azithromycin-chloroquine and the intermittent preventive treatment of malaria in pregnancy. [PDF]

, 2008
In the high malaria-transmission settings of sub-Saharan Africa, malaria in pregnancy is an important cause of maternal, perinatal and neonatal morbidity.
Chandramohan, Daniel, Chico, R Matthew, Pittrof, Rudiger, Pittrof Rudiger, Daniel Chandramohan, Chico R Matthew, Greenwood Brian, Rudiger Pittrof, Greenwood, Brian, Brian Greenwood, Chandramohan Daniel, R Matthew Chico   +11 more
core   +1 more source

Prevalence and trends in transmitted and acquired antiretroviral drug resistance, Washington, DC, 1999–2014

BMC Research Notes, 2017
Background Drug resistance limits options for antiretroviral therapy (ART) and results in poorer health outcomes among HIV-infected persons. We sought to characterize resistance patterns and to identify predictors of resistance in Washington, DC. Methods
Annette M. Aldous, Amanda D. Castel, David M. Parenti, the DC Cohort Executive Committee   +3 more
doaj   +1 more source

New approaches to measuring anthelminthic drug efficacy : parasitological responses of childhood schistosome infections to treatment with praziquantel [PDF]

, 2015
By 2020, the global health community aims to control and eliminate human helminthiases, including schistosomiasis in selected African countries, principally by preventive chemotherapy (PCT) through mass drug administration (MDA) of anthelminthics ...
Scherrer, A U, Raso, G, Utzinger, Jürg, Alexandra U. Scherrer, King, Charles H., Coulibaly, Jean T., Walker, Martin, Basanez, MG, Jean T. Coulibaly, Basáñez, M-G, King, CH, Martin Walker, Walker, M, Scherrer, Alexandra U., Sousa-Figueiredo, José Carlos, Katarina Stete, Mabud, Tarub S., Mabud, T, Stete, Katarina, Basáñez, Maria-Gloria, Coulibaly, J T, José Carlos Sousa-Figueiredo, Jürg Utzinger, Maria-Gloria Basáñez, Utzinger, J, Giovanna Raso, Scherrer, AU, Raso, Giovanna, Olliaro, Piero L., Stothard, JR, Stothard, J R, Sousa-Figueiredo, J C, Olliaro, PL, Coulibaly, JT, Sousa-Figueiredo, JC, Stothard, J. Russell, Charles H. King, King, C H, J. Russell Stothard, Tarub S. Mabud, Piero L. Olliaro, Olliaro, P L, Stete, K   +42 more
core   +1 more source

Drug resistance-conferring mutations in Mycobacterium tuberculosis from Madang, Papua New Guinea [PDF]

, 2012
: BACKGROUND: Monitoring drug resistance in Mycobacterium tuberculosis is essential to curb the spread of tuberculosis (TB). Unfortunately, drug susceptibility testing is currently not available in Papua New Guinea (PNG) and that impairs TB control in ...
Gagneux, S., Siba Peter, Beck, H. P., Hans-Peter Beck, Beck Hans-Peter, Carter Robyn, Paul Harino, Harino, P., Carter, R., Serej Ley, Ley Serej, Siba, P., Gagneux Sebastien, Borrell Sonia, Coscolla Mireia, Mireia Coscolla, Ballif Marie, Stefan Niemann, Ley, S., Marie Ballif, Coulter, C., Robyn Carter, Coulter Christopher, Christopher Coulter, Ballif, M., Peter Siba, Niemann, S., Harino Paul, Niemann Stefan, Sebastien Gagneux, Phuanukoonnon, S., Borrell, S., Coscolla, M., Sonia Borrell, Suparat Phuanukoonnon, Phuanukoonnon Suparat   +35 more
core   +1 more source

Epidemic Characteristics of HIV Drug Resistance in Hefei, Anhui Province

Pathogens, 2022
To study the characteristics of HIV pretreatment drug resistance (PDR) and acquired drug resistance (ADR) in Hefei, a cross-sectional survey was used to collect 816 samples from newly reported HIV infections from 2017 to 2020 and 127 samples from HIV ...
Shan Zheng, Jianjun Wu, Jingjing Hao, Dong Wang, Zhongwang Hu, Lei Liu, Chang Song, Jing Hu, Yanhua Lei, Hai Wang, Lingjie Liao, Yi Feng, Yiming Shao, Yuhua Ruan, Hui Xing   +14 more
doaj   +1 more source

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source

Biphasic Clinical Course of Pediatric Cytomegalovirus‐Associated Immune Thrombocytopenia: Early Poor Treatment Response but Favorable Long‐Term Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cytomegalovirus (CMV) is a recognized trigger of immune thrombocytopenia (ITP); however, its incidence and impact on disease course in children remain controversial. Therefore, we aimed to characterize the clinical course of pediatric patients with CMV‐associated ITP.
Oded Gilad, Ohad Atia, Osama Tanous, Dafna Brik Simon, Michal Dvori, Miriam Cohen, Tracie A. Goldberg, Efraim Bilavsky, Joanne Yacobovich, Orna Steinberg‐Shemer   +9 more
wiley   +1 more source

Characterizing the emergence and persistence of drug resistant mutations in HIV-1 subtype C infections using 454 ultra deep pyrosequencing. [PDF]

, 2013
BACKGROUND: The role of HIV-1 RNA in the emergence of resistance to antiretroviral therapies (ARTs) is well documented while less is known about the role of historical viruses stored in the proviral DNA. The primary focus of this work was to characterize
Grace P McCormack, Crampin, Amelia C., Bansode, Vijay, McCormack, Grace P., Glynn, Judith R., Neil French, Ram K Shrestha, Travers, Simon A, Simon A Travers, French, Neil, Glynn, Judith R, Crampin, Amelia C, Vijay Bansode, Judith R Glynn, Vijay Bansode, Amelia C Crampin, McCormack, Grace P, Travers, Simon A., Shrestha, Ram K., Ngwira, Bagrey, Shrestha, Ram K, Bagrey Ngwira, Bansode Vijay, French Neil, Ngwira Bagrey, Crampin Amelia C, McCormack Grace P, Travers Simon A, Glynn Judith R, Shrestha Ram K   +29 more
core   +2 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Predicting the risk and speed of drug resistance emerging in soil-transmitted helminths during preventive chemotherapy

Nature Communications
Control of soil-transmitted helminths relies heavily on regular large-scale deworming of high-risk groups (e.g., children) with benzimidazole derivatives.
Luc E. Coffeng, Wilma A. Stolk, Sake J. de Vlas   +2 more
doaj   +1 more source