Results 81 to 90 of about 79,702 (253)

Prevalence and transmission dynamics of HIV-1 transmitted drug resistance in a southeastern cohort [PDF]

, 2018
Background. Transmitted drug resistance (TDR) compromises clinical management and outcomes. Transmitted drug resistance surveillance and identification of growing transmission clusters are needed in the Southeast, the epicenter of the US HIV epidemic ...
Sebastian, J., Dennis, A.M., Mkumba, L., Hué, S., Virkud, A., Eron, J.J., Levintow, S.N., Miller, W.C., Napravnik, S., Okeke, N.L.   +9 more
core   +2 more sources

Drug resistance from preferred antiretroviral regimens for HIV infection in South Africa: A modeling study.

PLoS ONE, 2019
BACKGROUND:Tenofovir-containing regimens comprise the preferred first-line antiretroviral therapy (ART) in many countries including South Africa, where utilization of second-line regimens is limited.
Ume L Abbas, Robert L Glaubius, Yajun Ding, Gregory Hood   +3 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Characteristics of patients with and without transmitted drug resistance (TDR).

, 2012
Characteristics of patients with and without transmitted drug resistance (TDR).
Jan Albert (176517), Göran Bratt (176495), Mattias Mild (176512), Håkan Ekvall (176499), Annika Karlsson (176486), Per Björkman (51007), Magnus Gisslén (176506), Anders Sönnerborg (153581)   +7 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Transmitted Drug Resistance by ARV Class and Virologic Outcome.

, 2013
Transmitted Drug Resistance by ARV Class and Virologic Outcome: Note: TDRs are not mutually exclusive (i.e. a subject could have a TDR from more than one ARV class).
Jonathan Uy (143781), Marco Mancini (364356), Rong Yang (107028), Donnie McGrath (364357), Max Lataillade (183356), Daniel Seekins (183368), Mark Krystal (364355), Jennifer Chiarella (183360), Steven Schnittman (364353), Victoria Wirtz (364354), Michael Kozal (183380), Michael Egholm (180599), Birgitte Simen (183369)   +12 more
core   +1 more source

Prevalence and persistence of transmitted drug resistance mutations in the German HIV-1 Seroconverter Study Cohort.

PLoS ONE, 2019
The prevalence of transmitted drug resistance (TDR) in antiretroviral therapy (ART)-naïve individuals remains stable in most developed countries despite a decrease in the prevalence of acquired drug resistance.
Patrycja Machnowska, Karolin Meixenberger, Daniel Schmidt, Heiko Jessen, Heribert Hillenbrand, Barbara Gunsenheimer-Bartmeyer, Osamah Hamouda, Claudia Kücherer, Norbert Bannert, German HIV-1 Seroconverter Study Group   +9 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source