Results 81 to 90 of about 4,157,477 (289)

Clinically Relevant Transmitted Drug Resistance to First Line Antiretroviral Drugs and Implications for Recommendations

PLoS ONE, 2014
The aim was to analyse trends in clinically relevant resistance to first-line antiretroviral drugs in Spain, applying the Stanford algorithm, and to compare these results with reported Transmitted Drug Resistance (TDR) defined by the 2009 update of the WHO SDRM list.We analysed 2781 sequences from ARV naive patients of the CoRIS cohort (Spain) between ...
Monge Corella, Susana, Guillot, Vicente, Alvarez, Marta, Chueca, Natalia, Stella, Natalia, Peña, Alejandro, Delgado, Rafael, Córdoba, Juan, Aguilera, Antonio (Aguilera Martín), Vidal Lancis, Maria Carmen, García, Federico, Miró Meda, José M. (José María), 1956-, Gatell, José M.   +12 more
openaire   +9 more sources

Surveillance of transmitted HIV drug resistance among newly diagnosed, treatment-naive individuals at a county HIV clinic in Santa Clara County

Heliyon, 2019
Introduction: To our knowledge, HIV transmitted drug resistance (TDR) patterns have not been characterized specifically in Santa Clara County (SCC), California, one of the largest counties by population in the United States.
William Chan, Wilson Ly
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Temporal trends of transmitted HIV drug resistance in a multinational seroconversion cohort [PDF]

AIDS, 2018
The rate of transmitted drug resistance (TDR) may increase with wider use of antiretroviral therapy and can contribute to therapeutic failure. We analysed time trends in TDR among HIV seroconverters.Using CASCADE data of individuals with well estimated dates of HIV seroconversion, we examined HIV nucleotide sequences collected prior to antiretroviral ...
Olson, A, Bannert, N, Soennerborg, A, de Mendoza, C, Price, M, Zangerle, R, Chaix, M-L, Prins, M, Kran, A-MB, Gill, J, Paraskevis, D, Porter, K   +11 more
openaire   +5 more sources

Low-cost ultra-wide genotyping using Roche/454 pyrosequencing for surveillance of HIV drug resistance. [PDF]

PLoS ONE, 2012
Great efforts have been made to increase accessibility of HIV antiretroviral therapy (ART) in low and middle-income countries. The threat of wide-scale emergence of drug resistance could severely hamper ART scale-up efforts. Population-based surveillance
Dawn M Dudley, Emily N Chin, Benjamin N Bimber, Sabri S Sanabani, Leandro F Tarosso, Priscilla R Costa, Mariana M Sauer, Esper G Kallas, David H O'Connor   +8 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Patterns of Transmitted HIV Drug Resistance in Europe Vary by Risk Group

PLoS ONE, 2014
In Europe, a continuous programme (SPREAD) has been in place for ten years to study transmission of drug resistant HIV. We analysed time trends of transmitted drug resistance mutations (TDRM) in relation to the risk behaviour reported.HIV-1 patients newly diagnosed in 27 countries from 2002 through 2007 were included.
Frentz, D., Van De Vijver, D., Abecasis, A. B., Albert, Jan, Hamouda, O., Jørgensen, L., Kücherer, C., Struck, D., Schmit, J. -C, Vercauteren, J., Åsjö, Birgitta, Balotta, Claudia, Bergin, C., Beshkov, Danail, Camacho, Ricardo J., Clotet, B., Griskevicius, A., Grossman, Z., Horban, A., Kolupajeva, T., Korn, K., Kostrikis, Leontios G., Linka, K. L. M., Nielsen, C., Otelea, D., Paraskevis, Dimitrios N., Paredes, R., Poljak, M., Puchhammer-Stöckl, E., Sönnerborg, A., Stanekova, D., Stanojevic, M., Vandamme, A. -M, Boucher, C., Wensing, A., Frentz, D., Van De Vijver, D., Abecasis, A. B., Albert, Jan, Hamouda, O., Jørgensen, L., Kücherer, C., Struck, D., Schmit, J. -C, Vercauteren, J., Åsjö, Birgitta, Balotta, Claudia, Bergin, C., Beshkov, Danail, Camacho, Ricardo J., Clotet, B., Griskevicius, A., Grossman, Z., Horban, A., Kolupajeva, T., Korn, K., Kostrikis, Leontios G., Linka, K. L. M., Nielsen, C., Otelea, D., Paraskevis, Dimitrios N., Paredes, R., Poljak, M., Puchhammer-Stöckl, E., Sönnerborg, A., Stanekova, D., Stanojevic, M., Vandamme, A. -M, Boucher, C., Wensing, A.   +69 more
openaire   +12 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Drug resistance mutations in drug-naive HIV type 1 subtype C-infected individuals from rural Malawi. [PDF]

, 2010
In this preliminary study we show that in 2008, 3 years after antiretroviral therapy was introduced into the Karonga District, Malawi, a greater than expected number of drug-naive individuals have been infected with HIV-1 subtype C virus harboring major ...
Grace P. McCormack, Emmanuel Banda, Judith R. Glynn, Bansode, Vijay, McCormack, Grace P., Glynn, Judith R., Neil French, French, Neil, Glynn, Judith R, Zuzanna J. Drebert, Banda, Emmanuel, Drebert, Zuzanna J., Molesworth, Anna, Vijay Bansode, Travers, Simon AA, Amelia Crampin, Drebert, Zuzanna, McCormack, Grace P, Crampin, Amelia, Anna Molesworth, Drebert, Zuzanna J, Simon A.A. Travers, Travers, Simon A A, Travers, Simon A.A., Ngwira, Bagrey, Bagrey Ngwira   +25 more
core   +1 more source