Results 101 to 110 of about 79,702 (253)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Orally active antischistosomal early leads identified from the open access malaria box. [PDF]

, 2014
BACKGROUND: Worldwide hundreds of millions of schistosomiasis patients rely on treatment with a single drug, praziquantel. Therapeutic limitations and the threat of praziquantel resistance underline the need to discover and develop next generation drugs.
Wells, Timothy N. C., Bickle, Quentin D, Bickle, Quentin D., Mansour Nuha R., Jennifer Keiser, Wells, Timothy NC, Bickle, Quentin, Bickle Quentin D., Nuha R. Mansour (146895), Geary, Timothy G., Panic, Gordana, Vargas Mireille, Gordana Panic, Katrin Ingram-Sieber (507683), Cowan, Noemi, Mansour, Nuha, Quentin D. Bickle (146947), Jennifer Keiser (39606), Noemi Cowan (507684), Quentin D. Bickle, Mansour, Nuha R., Katrin Ingram-Sieber, Spangenberg, Thomas, Mireille Vargas, Thomas Spangenberg (422569), Cowan Noemi, Keiser Jennifer, Mireille Vargas (392661), Ingram-Sieber, Katrin, Timothy N C Wells, Quentin D Bickle, Noemi Cowan, Panic Gordana, Timothy N. C. Wells (422572), Ingram-Sieber Katrin, Wells Timothy N. C., Nuha R Mansour, Timothy N. C. Wells, Gordana Panic (507685), Mansour, Nuha R, Keiser, Jennifer, Thomas Spangenberg, Nuha R. Mansour, Spangenberg Thomas, Vargas, Mireille   +44 more
core   +1 more source

Transmitted and Acquired HIV-1 Drug Resistance from a Family: A Case Study

Infection and Drug Resistance, 2020
Liting Yan,1,2,* Fengting Yu,1,2,* Huimin Zhang,1,3 Hongxin Zhao,1,2 Linghang Wang,1,2 Zaiyan Liang,1,2 Xia Zhang,1,2 Liang Wu,1,2 Hongyuan Liang,1,2 Siyuan Yang,1,2 Yunxia Tang,1,2 Fujie Zhang1,2 1Beijing Ditan Hospital, Capital Medical University ...
Yan L, Yu F, Zhang H, Zhao H, Wang L, Liang Z, Zhang X, Wu L, Liang H, Yang S, Tang Y, Zhang F   +11 more
doaj  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

HIV-1 drug resistance and genetic transmission networks among patients with sexually transmitted HIV in Ningxia, China

Frontiers in Public Health
BackgroundOver the past decade, sexual transmission has become a dominant source of new HIV-1 infection in China. However, very few studies have been conducted to characterize the two sexual transmissions, homosexual and heterosexual transmission.
Jianxin Pei, Zhonglan Wu, Zhonglan Wu, Bingqian Si, Chunhua Ma, Yichang Liu, Xiaofa Ma, Wenhe Kuai, Yinhao Zhang, Yong Li   +9 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

HIV-1 genetic diversity and resistance to antiretroviral drugs among pregnant women in Ribeirão Preto (SP), Brazil. Cross-sectional study

São Paulo Medical Journal
BACKGROUND: Increasing genetic diversity of HIV-1 and emergence of drug-resistant mutations may reduce the efficacy of antiretroviral therapy and prophylaxis that are used to prevent mother-to-child transmission.
Ana Teresa Mancini Pimenta, Isadora Alonso Correa, Patricia Pereira dos Santos Melli, Renata Abduch, Geraldo Duarte, José Carlos Couto-Fernandez, Silvana Maria Quintana   +6 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Sensitivity of Six Tier 1 RTI resistance mutations for detecting transmitted or acquired drug resistance.

, 2016
Cumulative prevalence or sensitivity of the Six Tier 1 RT inhibitor (RTI) drug-resistance mutations (DRMs) for detecting transmitted or acquired drug resistance in viruses from individuals with intermediate or high-level NRTI or NNRTI resistance is shown.
Neil Parkin (273844), Annemarie M. J. Wensing (105565), Rami Kantor (7863), Soo-Yon Rhee (42412), Elliot Raizes (840995), Mark A. Wainberg (196455), Irene Mukui (757883), Douglas D. Richman (168764), Mina C. Hosseinipour (143744), Jonathan M. Schapiro (374093), Joseph E. Fitzgibbon (840997), Marco Schito (840998), Carole L. Wallis (326872), Nicaise Ndembi (703630), Michael R. Jordan (146520), Raph L. Hamers (718072), Avelin F. Aghokeng (322582), Clement Zeh (226174), Gert U. Van Zyl (427181), Michele Tang (840996), Robert W. Shafer (32534), Tobias F. Rinke de Wit (178193), Joseph Fokam (322576), Lisa M. Frenkel (337077), Chunfu Yang (293864), Arlene Chua (134856), Joel E. Gallant (348304), David Katzenstein (182035), Silvia Bertagnolio (57174), Ravindra K. Gupta (372679), Tulio De Oliveira (5666317), Sergio Carmona (562195)   +31 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source