Results 31 to 40 of about 490,106 (255)

Expanding Indications of Liver Transplantation in Spain: Consensus Statement and Recommendations by the Spanish Society of Liver Transplantation [PDF]

, 2020
Trasplantament de fetge; Hepatitis C; ConsensTrasplante de hígado; Hepatitis C; ConsensoLiver Transplantation; Hepatitis C; ConsensusBackground. The number of patients awaiting liver transplantation (LT) in Spain has halved from 2015 to 2019 due to the
Jordi Colmenero, De la Rosa, Gloria, Bilbao Aguirre, Itxarone Izaskun, Rodríguez-Perálvarez, Manuel, Gloria Sánchez-Antolín, Miguel Ángel Gómez-Bravo, Gómez Bravo, Miguel Ángel, Bilbao, Itxarone, Gómez-Bravo, Miguel Ángel, Manuel Rodríguez-Perálvarez, Itxarone Bilbao, Sánchez-Antolín, Gloria, De-la-Rosa, Gloria, Colmenero, Jordi, Gloria De la Rosa   +14 more
core   +1 more source

T Cell Repertoire Maturation Induced by Persistent and Latent Viral Infection Is Insufficient to Induce Costimulation Blockade Resistant Organ Allograft Rejection in Mice

Frontiers in Immunology, 2018
CD28:CD80/86 pathway costimulation blockade (CoB) with the CD80/86-specific fusion protein CTLA4-Ig prevents T cell-mediated allograft rejection in mice.
Jaclyn R. Espinosa, Jaclyn R. Espinosa, Danny Mou, Bartley W. Adams, Louis R. DiBernardo, Andrea L. MacDonald, MacKenzie McRae, Allison N. Miller, Mingqing Song, Linda L. Stempora, Jun Wang, Neal N. Iwakoshi, Allan D. Kirk   +12 more
doaj   +1 more source

Combination of heterologous fibrin sealant and bioengineered human embryonic stem cells to improve regeneration following autogenous sciatic nerve grafting repair

Journal of Venomous Animals and Toxins including Tropical Diseases, 2018
Background Peripheral nerve injury is a worldwide clinical problem, and the preferred surgical method for treating it is the end-to-end neurorrhaphy. When it is not possible due to a large nerve gap, autologous nerve grafting is used.
Roghayeh Mozafari, Sergiy Kyrylenko, Mateus Vidigal Castro, Rui Seabra Ferreira, Benedito Barraviera, Alexandre Leite Rodrigues Oliveira   +5 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The International Liver Transplantation Society living donor liver transplant recipient guideline

, 2017
Living donor liver transplantation (LDLT) has been increasingly embraced around the world as an important strategy to address the shortage of deceased donor livers.
Lo, CM, Quintini, Cristiano, Lee, SG, Durand, F, Kyrana, E, Lerut, J, Kyrana, Eirini, Lee, Sung-Gyu, Kim-Schluger, HL, Quintini, C, Kim-Schluger, Hyung Leona, Pomfret, Elizabeth Anne, Heimbach, Julie K, Lerut, Jan, Miller, Charles M, Dhawan, A, Dhawan, Anil, Durand, Francois, Lo, Chung-Mau, Miller, CM, Heimbach, JK, Pomfret, EA   +21 more
core   +1 more source

Induced Foxp3+ T cells colonising tolerated allografts exhibit the hypomethylation pattern typical of mature regulatory T cells.

Frontiers in Immunology, 2016
Regulatory T cells expressing the transcription factor Foxp3 require acquisition of a specific hypomethylation pattern to ensure optimal functional commitment, limited lineage plasticity and long-term maintenance of tolerance.
Robert eHilbrands, Ye eChen, Adrian eKendal, Elizabeth eAdams, Stephen Paul Cobbold, Herman eWaldmann, Duncan eHowie   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

Influence of Liver Transplantation on Neuropsychiatric Manifestations of Wilson Disease

, 2015
Objectives. This study sought to evaluate the effect of liver transplantation on the neuropsychological manifestations of Wilson disease. Materials and Methods.
Tardu, A., Ince, V., Karagul, S., Unal, B., Yagci, M. A., Kirmizi, S., Ertugrul, I., Karagül, Servet, YILMAZ, SEZAİ, Kayaalp, Cüneyt, Ünal, Bülent, Tardu, Ali, IŞIK, BURAK, Işık, Burak, Yağcı, Mehmet Ali, İnce, Volkan, Kırmızı, Serdar, Yılmaz, Sezai, Ertuğrul, İsmail   +18 more
core   +1 more source

Complete Microbiota Engraftment Is Not Essential for Recovery from Recurrent Clostridium difficile Infection following Fecal Microbiota Transplantation

mBio, 2016
Bacterial communities from subjects treated for recurrent Clostridium difficile infection (rCDI) by fecal microbiota transplantation (FMT), using either heterologous donor stool samples or autologous stool samples, were characterized by Illumina next ...
Christopher Staley, Colleen R. Kelly, Lawrence J. Brandt, Alexander Khoruts, Michael J. Sadowsky   +4 more
doaj   +1 more source