Results 31 to 40 of about 1,124,538 (196)

Carbon monoxide-releasing molecules protect against ischemia-reperfusion injury during kidney transplantation.

open access: yesKidney International, 2011
Carbon monoxide (CO) can provide beneficial antiapoptotic and anti-inflammatory effects in the context of ischemia–reperfusion injury (IRI). Here we tested the ability of pretreating the kidney donor with carbon monoxide-releasing molecules (CORM) to ...
Y. Caumartin   +10 more
semanticscholar   +2 more sources

Exogenous Lipocalin 2 Ameliorates Acute Rejection in a Mouse Model of Renal Transplantation

open access: yesAmerican Journal of Transplantation, Volume 16, Issue 3, Page 808-820, March 2016., 2016
Abstract Lipocalin 2 (Lcn2) is rapidly produced by damaged nephron epithelia and is one of the most promising new markers of renal injury, delayed graft function and acute allograft rejection (AR); however, the functional importance of Lcn2 in renal transplantation is largely unknown. To understand the role of Lcn2 in renal AR, kidneys from Balb/c mice
M. I. Ashraf   +9 more
wiley   +1 more source

Extracellular Vesicles from MSC Modulate the Immune Response to Renal Allografts in a MHC Disparate Rat Model

open access: yesStem Cells International, Volume 2015, Issue 1, 2015., 2015
Application of mesenchymal stromal cells (MSC) has been proposed for solid organ transplantation based on their potent immunomodulatory effects. Since side effects from the injection of large cells cannot be excluded, the hypothesis rises that extracellular vesicles (EV) may cause immunomodulatory effects comparable to MSC without additional side ...
M. Koch, A. Lemke, C. Lange, Eva Mezey
wiley   +1 more source

Two Faces of TGF‐Beta1 in Breast Cancer

open access: yesMediators of Inflammation, Volume 2014, Issue 1, 2014., 2014
Breast cancer (BC) is potentially life‐threatening malignancy that still causes high mortality among women. Scientific research in this field is focused on deeper understanding of pathogenesis and progressing of BC, in order to develop relevant diagnosis and improve therapeutic treatment. Multifunctional cytokine TGF‐β1 is one of many factors that have
Joanna Magdalena Zarzynska   +1 more
wiley   +1 more source

Cellular transplantation of nephrons

open access: yes, 2005
Cellular transplantation of nephrons. Embryonic renal cellular primordia transplanted into animal hosts undergo nephrogenesis in situ, become vascularized by blood vessels of host origin, exhibit excretory function, and support life in otherwise anephric
Hammerman, Marc R.
core   +1 more source

Immunological Barriers to Stem Cell Therapy in the Central Nervous System

open access: yesStem Cells International, Volume 2014, Issue 1, 2014., 2014
The central nervous system is vulnerable to many neurodegenerative disorders such as Alzheimer’s disease that result in the extensive loss of neuronal cells. Stem cells have the ability to differentiate into many types of cells, which make them ideal for treating such disorders.
Gregory E. Tullis   +3 more
wiley   +1 more source

IL-10, TGF-β, IL-2, IL-6, IL-17, IL-23, TNF-α, and IFN-γ concentrations in recipient serum and intestinal grafts (S1 and S2 Tables).

open access: yes, 2014
Cytokine concentrations in the recipient serum and intestinal grafts were measured by ELISA on day 1, 5, 7, and 10 after transplantation. Data are expressed as mean ± SD (p≤0.05 compared with *nontransplanted controls; #isogeneic controls; +allogeneic ...
Wei-Ping Zheng (674857)   +7 more
core   +1 more source

Late transplantation period of mice fetal intestine grafts: Morphometric aspects

open access: yes, 2007
Morphometric evaluation of the fetal intestinal graft in the late post-transplant period was done by using C57BL/6 mice. Under anesthesia, after hysterotomy, a transversal laparotomy was done in the fetus to harvest all intestines.
Ricardo Artigiani   +9 more
core   +1 more source

Synergistic Effect of Hyperglycemia and p27kip1 Suppression on Adult Mouse Islet Beta Cell Replication

open access: yesInternational Journal of Endocrinology, Volume 2012, Issue 1, 2012., 2012
The complementary role of hyperglycemia and p27kip1 suppression on islet beta cell regeneration was investigated in a syngeneic mouse model. p27kip1 gene silencing was performed by infecting islets of C57BL/6 with shRNA lentiviral particles. At 54 hours after viral infection, p27kip1 protein content in cultured targeting islets was 22% of that in ...
Szu-Tah Chen   +5 more
wiley   +1 more source

High Yield of Rodent Islets with Intraductal Collagenase and Stationary Digestion—A Comparison with Standard Technique

open access: yesCell Transplantation, 1996
Intraductal distention of the pancreas with collagenase followed by stationary warm incubation improves the recovery of islets of Langerhans in the rat, but controlled studies are needed for valid comparison with standard isolation methods.
A.M. James Shapiro   +3 more
doaj   +1 more source

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