Results 141 to 150 of about 5,669 (241)

Impairment of Innate Immunity and Depletion of Vaccine‐Induced Memory B and T Cells in the Absence of the Spleen

American Journal of Hematology, Volume 100, Issue 5, Page 770-784, May 2025.
ABSTRACT Splenectomy or congenital asplenia is associated with severe reduction of memory B cells and increased risk of fulminant sepsis by encapsulated bacteria. Current guidelines recommend vaccinations against these pathogens before or after splenectomy, but the longevity of immunity acquired after splenectomy has not been determined.
Veronica Bordoni, Bianca Laura Cinicola, Eva Piano Mortari, Concetta Castilletti, Federica Guarracino, Christian Albano, Silvia Accordini, Anwar Baban, Antonio Di Sabatino, Carlo Maria Rossi, Marco Vincenzo Lenti, Anna Maria Zicari, Riccardo Cirelli, Marco Spada, Gian Luca Forni, Isabella Quinti, Mattia Algeri, Maddalena Casale, Silverio Perrotta, Franco Locatelli, Chiara Agrati, Rita Carsetti   +21 more
wiley   +1 more source

Clinical Outcomes and Treatment Strategies of Adult Transplant‐Associated Thrombotic Microangiopathy: External Validation of Harmonizing Definitions and High‐Risk Criteria

American Journal of Hematology, Volume 100, Issue 5, Page 830-839, May 2025.
ABSTRACT Transplant‐associated thrombotic microangiopathy (TA‐TMA) is an endothelial dysfunction syndrome observed after allogeneic hematopoietic cell transplant (alloHCT). Our aim was to externally validate the impact of high‐risk features on the clinical outcomes of adult patients meeting the updated TA‐TMA harmonizing criteria. Between 2005 and 2022,
Aldo A. Acosta‐Medina, Meera Sridharan, Ronald S. Go, Ann M. Moyer, Nelson Leung, Maria Alice V. Willrich, Robert Wolf, Rabee Kassis, Almothana Manasrah, Mira A. Kohorst, Urshila Durani, Aasiya Matin, Mehrdad Hefazi, Saad J. Kenderian, Abhishek A. Mangaonkar, Mithun V. Shah, Mark R. Litzow, William J. Hogan, David Dingli, Hassan B. Alkhateeb   +19 more
wiley   +1 more source

TP53 ‐Mutated Myeloid Neoplasms: 2024 Update on Diagnosis, Risk‐Stratification, and Management

American Journal of Hematology, Volume 100, Issue S4, Page 88-115, June 2025.
ABSTRACT Alterations in the tumor suppressor gene TP53 are common in human cancers and are associated with an aggressive nature. Approximately 8%–12% of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) harbor TP53 mutations (TP53 mut) and present immense challenges due to inherent chemoresistance and poor outcomes.
Mithun Vinod Shah, Daniel A. Arber, Devendra K. Hiwase   +2 more
wiley   +1 more source

Classification of Myelodysplastic, Myeloproliferative, and Myelodysplastic/Myeloproliferative Neoplasms: The Past, Present, and Future

American Journal of Hematology, Volume 100, Issue S4, Page 5-15, June 2025.
ABSTRACT With the recent publication of new classification systems of hematopoietic neoplasms, understanding how recognition of disease entities has occurred over time and the subsequent development of formal disease classifications is of importance. This review focuses on the early recognition of myeloid disorders, especially chronic myeloid disorders,
Daniel A. Arber, Attilio Orazi
wiley   +1 more source

Targeted Therapies in Myelofibrosis: Present Landscape, Ongoing Studies, and Future Perspectives

American Journal of Hematology, Volume 100, Issue S4, Page 30-50, June 2025.
ABSTRACT Myelofibrosis (MF) is a myeloproliferative neoplasm that is accompanied by driver JAK2, CALR, or MPL mutations in more than 90% of cases, leading to constitutive activation of the JAK–STAT pathway. MF is a multifaceted disease characterized by trilineage myeloid proliferation with prominent megakaryocyte atypia and bone marrow fibrosis, as ...
Giuseppe G. Loscocco, Paola Guglielmelli
wiley   +1 more source

Randomized preclinical study of machine perfusion in vascularized composite allografts

BJS (British Journal of Surgery), EarlyView., 2020
This study was designed to identify the optimum machine perfusion parameters for preservation of limbs before transplantation, and determine whether this was better than cold storage. Normothermic machine perfusion at a pressure of 70 mmHg (NMP‐70) provided superior preservation to cold storage after transplantation.
K. R. Amin, J. P. Stone, J. Kerr, A. Geraghty, L. Joseph, A. Montero‐Fernandez, J. K. Wong, J. E. Fildes   +7 more
wiley   +1 more source

Uniform weighted inequalities for the Hankel transform transplantation operator [PDF]

arXiv
In this paper we present uniform weighted inequalities for the Hankel transform transplantation operator. A weighted vector-valued inequality is also obtained. As a consequence we deduce an extension of a transference theorem due to Rubio de Francia.
arxiv  

Allogeneic Stem Cell Transplant for Myelofibrosis and Myelodysplastic Syndromes: A Contemporary Review

American Journal of Hematology, Volume 100, Issue S4, Page 16-29, June 2025.
ABSTRACT Allogeneic hematopoietic stem‐cell transplantation (HCT) remains the only potentially curative therapy for patients with myelodysplastic neoplasms (MDS) and myelofibrosis (MF) and is the standard care for eligible patients with higher‐risk disease. Despite significant advancements, both diseases pose unique challenges due to their clinical and
Nico Gagelmann, Nicolaus Kröger
wiley   +1 more source

A Phase II Trial of Geriatric Assessment‐Guided Selection of Treatment Intensity in Older Adults With AML

American Journal of Hematology, EarlyView.
ABSTRACT How to select the appropriate intensity of chemotherapy in older adults with acute myeloid leukemia (AML) remains an unanswered question. In a phase II trial of older adults ≥ 60 years with AML (n = 73), we used geriatric assessment (measures of comorbidity burden, physical and cognitive function) to determine fitness for intensive ...
Vijaya R. Bhatt, Christopher S. Wichman, Thuy T. Koll, Alfred L. Fisher, Tanya M. Wildes, Michael Haddadin, Ann M. Berger, James O. Armitage, Sarah A. Holstein, Lori J. Maness, Krishna Gundabolu   +10 more
wiley   +1 more source

Revisiting transplant immunology through the lens of single-cell technologies [PDF]

, 2022
Arianna Barbetta, Brittany Rocque, Deepika Sarode, Johanna Ascher Bartlett, Juliet Emamaullee   +4 more
openalex   +1 more source