Results 41 to 50 of about 1,273,742 (384)
The Journal of Clinical Investigation, 2022 Primary graft dysfunction (PGD) is the leading cause of postoperative mortality in lung transplant recipients and the most important risk factor for development of chronic lung allograft dysfunction.
Melissa Querrey +11 more
doaj +1 more source
Transplant: immunology and treatment of rejection
American Journal of Kidney Diseases, 2004 Connie L. Davis
openalex +4 more sources
The Journal of Clinical Investigation, 2022 Solid organ transplantation is the preferred treatment for end-stage organ failure. Although transplant recipients take life-long immunosuppressive drugs, a substantial percentage of them still reject their allografts.
Isabella Pirozzolo +11 more
doaj +1 more source
Memory NK cell features exploitable in anticancer immunotherapy [PDF]
, 2019 Besides their innate ability to rapidly produce effector cytokines and kill virus-infected or transformed cells, natural killer (NK) cells display a strong capability to adapt to environmental modifications and to differentiate into long-lived ...
Battella, Simone +5 more
core +2 more sources
NK and CD8+ T cell phenotypes predict onset and control of CMV viremia after kidney transplant
JCI Insight, 2021 CMV causes mostly asymptomatic but lifelong infection. Primary infection or reactivation in immunocompromised individuals can be life-threatening. CMV viremia often occurs in solid organ transplant recipients and associates with decreased graft survival ...
Harry Pickering +17 more
doaj +1 more source
ACTH treatment promotes murine cardiac allograft acceptance
JCI Insight, 2021 Heart transplantation is the optimal therapy for patients with end-stage heart disease, but its long-term outcome remains inadequate. Recent studies have highlighted the importance of the melanocortin receptors (MCRs) in inflammation, but how MCRs ...
Jing Zhao +13 more
doaj +1 more source
JCI Insight, 2021 Alloimmune responses driven by donor-specific antibodies (DSAs) can lead to antibody-mediated rejection (ABMR) in organ transplantation. Yet, the cellular states underlying alloreactive B cell responses and the molecular components controlling them ...
Kevin Louis +14 more
doaj +1 more source
Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
wiley +1 more source
IL-33 acts as a costimulatory signal to generate alloreactive Th1 cells in graft-versus-host disease
The Journal of Clinical Investigation, 2022 Antigen-presenting cells (APCs) integrate signals emanating from local pathology and program appropriate T cell responses. In allogeneic hematopoietic stem cell transplantation (alloHCT), recipient conditioning releases damage-associated molecular ...
Gaelen K. Dwyer +10 more
doaj +1 more source
Gene Expression Profiling of Bronchoalveolar Lavage Cells Preceding a Clinical Diagnosis of Chronic Lung Allograft Dysfunction. [PDF]
, 2017 BackgroundChronic Lung Allograft Dysfunction (CLAD) is the main limitation to long-term survival after lung transplantation. Although CLAD is usually not responsive to treatment, earlier identification may improve treatment prospects.MethodsIn a nested ...
Ardehali, Abbas +15 more
core +2 more sources