Results 41 to 50 of about 1,247,898 (402)
Stem Cell Transplantation As A Dynamical System: Are Clinical Outcomes Deterministic? [PDF]
Frontiers in Immunology (2014). 5:613, 2014 Outcomes in stem cell transplantation (SCT) are modeled using probability theory. However the clinical course following SCT appears to demonstrate many characteristics of dynamical systems, especially when outcomes are considered in the context of immune reconstitution.
arxiv +1 more source
IL-33 acts as a costimulatory signal to generate alloreactive Th1 cells in graft-versus-host disease
The Journal of Clinical Investigation, 2022 Antigen-presenting cells (APCs) integrate signals emanating from local pathology and program appropriate T cell responses. In allogeneic hematopoietic stem cell transplantation (alloHCT), recipient conditioning releases damage-associated molecular ...
Gaelen K. Dwyer +10 more
doaj +1 more source
ACTH treatment promotes murine cardiac allograft acceptance
JCI Insight, 2021 Heart transplantation is the optimal therapy for patients with end-stage heart disease, but its long-term outcome remains inadequate. Recent studies have highlighted the importance of the melanocortin receptors (MCRs) in inflammation, but how MCRs ...
Jing Zhao +13 more
doaj +1 more source
In Silico Derivation of HLA-Specific Alloreactivity Potential from Whole Exome Sequencing of Stem Cell Transplant Donors and Recipients: Understanding the Quantitative Immuno-biology of Allogeneic Transplantation [PDF]
Frontiers in Immunology 2014. 5:529, 2014 Donor T cell mediated graft vs. host effects may result from the aggregate alloreactivity to minor histocompatibility antigens (mHA) presented by the HLA in each donor-recipient pair (DRP) undergoing stem cell transplantation (SCT). Whole exome sequencing has demonstrated extensive nucleotide sequence variation in HLA-matched DRP. Non-synonymous single
arxiv +1 more source
Tregs integrate native and CAR-mediated costimulatory signals for control of allograft rejection
JCI Insight, 2023 Tregs expressing chimeric antigen receptors (CAR-Tregs) are a promising tool to promote transplant tolerance. The relationship between CAR structure and Treg function was studied in xenogeneic, immunodeficient mice, revealing advantages of CD28-encoding ...
Isaac Rosado-Sánchez +8 more
doaj +1 more source
IL-21–producing effector Tfh cells promote B cell alloimmunity in lymph nodes and kidney allografts
JCI Insight, 2023 Follicular helper T (Tfh) cells have been implicated in controlling rejection after allogeneic kidney transplantation, but the precise subsets, origins, and functions of Tfh cells in this process have not been fully characterized.
Hengcheng Zhang +12 more
doaj +1 more source
The Journal of Clinical Investigation, 2022 Primary graft dysfunction (PGD) is the leading cause of postoperative mortality in lung transplant recipients and the most important risk factor for development of chronic lung allograft dysfunction.
Melissa Querrey +11 more
doaj +1 more source
Decision Support System for Renal Transplantation [PDF]
In: Proceedings of the 2018 IISE Annual Conference: 2018; Orlando:
IISE; 2018: 431-436, 2018 The burgeoning need for kidney transplantation mandates immediate attention. Mismatch of deceased donor-recipient kidney leads to post-transplant death. To ensure ideal kidney donor-recipient match and minimize post-transplant deaths, the paper develops a prediction model that identifies factors that determine the probability of success of renal ...
arxiv +1 more source
The Journal of Clinical Investigation, 2022 Solid organ transplantation is the preferred treatment for end-stage organ failure. Although transplant recipients take life-long immunosuppressive drugs, a substantial percentage of them still reject their allografts.
Isabella Pirozzolo +11 more
doaj +1 more source
Family based HLA imputation and optimization of haplo-identical transplants [PDF]
arXiv, 2022 Recently, haplo-identical transplantation with multiple HLA mismatches has become a viable option for system cell transplants. Haplotype sharing detection requires imputation of donor and recipient. We show that even in high-resolution typing when all alleles are known, there is a 15% error rate in haplotype phasing, and even more in low resolution ...
arxiv