Results 61 to 70 of about 1,247,898 (402)

Relationship of transitional regulatory B and regulatory T cells and immunosuppressive drug doses in stable renal transplant recipients

Immunity, Inflammation and Disease, 2021
Objectives Regulatory B cells (Bregs) and T cells (Tregs) are thought to be involved in the regulation of graft acceptance in renal transplant recipients. However, mechanisms that affect Breg differentiation and interaction with Tregs are rather unclear.
Eman H Ibrahim, Mostafa Aly, Christian Morath, Douaa M Sayed, Naruemol Ekpoom, Gerhard Opelz, Caner Süsal, Volker Daniel   +7 more
doaj   +1 more source

Higher CD19+CD25+ Bregs are independently associated with better graft function in renal transplant recipients

BMC Nephrology, 2021
Background The Identification of B cell subsets with regulatory functions might open the way to new therapeutic strategies in the field of transplantation, which aim to reduce the dose of immunosuppressive drugs and prolong the graft survival.
Eman H. Ibrahim, Mostafa G. Aly, Gerhard Opelz, Christian Morath, Martin Zeier, Caner Süsal, Douaa M. Sayed, Eman Hassan, Naruemol Ekpoom, Volker Daniel   +9 more
doaj   +1 more source

Evaluation of transplant benefits with the U.S. Scientific Registry of Transplant Recipients by semiparametric regression of mean residual life [PDF]

arXiv, 2023
Kidney transplantation is the most effective renal replacement therapy for end stage renal disease patients. With the severe shortage of kidney supplies and for the clinical effectiveness of transplantation, patient's life expectancy post transplantation is used to prioritize patients for transplantation; however, severe comorbidity conditions and old ...
arxiv  

Virus-specific TRM cells of both donor and recipient origin reside in human kidney transplants

JCI Insight, 2023
Tissue-resident lymphocytes (TRLs) are critical for local protection against viral pathogens in peripheral tissue. However, it is unclear if TRLs perform a similar role in transplanted organs under chronic immunosuppressed conditions.
Daphne M. Hullegie-Peelen, Hector Tejeda Mora, Dennis A. Hesselink, Eric M.J. Bindels, Thierry P.P. van den Bosch, Marian C. Clahsen-van Groningen, Marjolein Dieterich, Sebastiaan Heidt, Robert C. Minnee, Georges M.G.M. Verjans, Martin J. Hoogduijn, Carla C. Baan   +11 more
doaj   +1 more source

Tools for histocompatibility testing and significance of panel reactive antibodies - A narrative review

Indian Journal of Transplantation, 2021
Immune response directed towards the allograft is a major barrier to the longterm graft survival in kidney transplantation. The importance of various tools for histocompatibility testing including the significance of panel reactive antibodies in ...
Praveen Kumar Etta
doaj   +1 more source

Predicting Kidney Transplant Survival using Multiple Feature Representations for HLAs [PDF]

Proceedings of the 19th International Conference on Artificial Intelligence in Medicine (2021) 51-60, 2021
Kidney transplantation can significantly enhance living standards for people suffering from end-stage renal disease. A significant factor that affects graft survival time (the time until the transplant fails and the patient requires another transplant) for kidney transplantation is the compatibility of the Human Leukocyte Antigens (HLAs) between the ...
arxiv  

IFN-γR/STAT1 signaling in recipient hematopoietic antigen-presenting cells suppresses graft-versus-host disease

The Journal of Clinical Investigation, 2023
The absence of IFN-γ receptor (IFN-γR) or STAT1 signaling in donor cells has been shown to result in reduced induction of acute graft-versus-host disease (GVHD).
Caisheng Lu, Huihui Ma, Liangsong Song, Hui Wang, Lily Wang, Shirong Li, Stephen M. Lagana, Antonia R. Sepulveda, Kasper Hoebe, Samuel S. Pan, Yong-Guang Yang, Suzanne Lentzsch, Markus Y. Mapara   +12 more
doaj   +1 more source

IMMUNOLOGICAL MONITORING IN TRANSPLANTATION [PDF]

Medical Journal Armed Forces India, 1997
Sixty eight patients who had undergone live related donor renal transplantation (LRD), were evaluated for soluble interleukin-2 receptors (sIL-2R), tumour necrosis factor alpha (TNF-α) and autoantibodies against IgG(Fab')2 and IgG(Fc), at pre- and various post-transplant intervals.
S C Dash, Narinder K. Mehra, G S Chopra, JR Bhardwaj   +3 more
openaire   +3 more sources

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

Suppression of allograft rejection by regulatory B cells induced via TLR signaling

JCI Insight, 2022
B lymphocytes have long been recognized for their critical contributions to adaptive immunity, providing defense against pathogens through cognate antigen presentation to T cells and Ab production.
Kang Mi Lee, Qiang Fu, Guoli Huai, Kevin Deng, Ji Lei, Lisa Kojima, Divyansh Agarwal, Peter van Galen, Shoko Kimura, Naoki Tanimine, Laura Washburn, Heidi Yeh, Ali Naji, Charles G. Rickert, Christian LeGuern, James F. Markmann   +15 more
doaj   +1 more source