Results 1 to 10 of about 5,934 (256)

Transportability of the comparative effect of finerenone for the treatment of symptomatic chronic heart failure with left ventricular ejection fraction of ≥40%: insights from the FINEARTS-HF trial [PDF]

Journal of Comparative Effectiveness Research
Aim: Global randomized controlled trials (RCTs) are used to inform reimbursement decisions in multiple markets, meaning the transportability of findings from these RCTs to multiple country-specific populations is critical for evidence-based decision ...
Alex J Turner, Claire Leboucher, Cécile Remuzat, Yik Ming Fung, Elena Pessina, Kerstin Folkerts   +5 more
doaj   +2 more sources

A General Algorithm for Deciding Transportability of Experimental Results

Journal of Causal Inference, 2013
Generalizing empirical findings to new environments, settings, or populations is essential in most scientific explorations. This article treats a particular problem of generalizability, called “transportability”, defined as a license to transfer ...
Elias Bareinboim, Judea Pearl
exaly   +2 more sources

Moving From Representativeness Toward Transportability in an Era of Digital and Big Data [PDF]

International Journal of Public Health
Evidence-based public health demands that study findings provide meaningful insights into improving the health of target populations, making representativeness a widely regarded hallmark of high-quality epidemiological research. However, big data and the
Arnaud Chiolero, Arnaud Chiolero, Arnaud Chiolero   +2 more
doaj   +2 more sources

Crossing borders: the need for empirical evidence of real-world evidence transportability in oncology [PDF]

Journal of Comparative Effectiveness Research
Plain language summary: What is this article about? This article discusses the challenges of using non local real-world evidence (RWE) in health technology assessments (HTA) when local data are unavailable, insufficient, or inappropriate.
Caitlin Clunie-O’Connor, Per-Olof Thuresson, Elizabeth Masters, Aliki Taylor, Mats Rosenlund, Philani Mpofu, Blythe Adamson   +6 more
doaj   +2 more sources

Evaluating transportability of in vitro cellular models to in vivo human phenotypes using gene perturbation data [PDF]

Nature Communications
Gene perturbation screens (e.g. CRISPR-Cas9) assess the impact of gene disruption on in-vitro cellular phenotypes (e.g., proliferation, anti-viral response). In-vitro experiments can be useful models for in-vivo (organismal) phenotypes (e.g., immune cell
Laurence J. Howe, Yurii S. Aulchenko, George Davey Smith, Neil M. Davies, Jorge Esparza-Gordillo, Toby Johnson, Jimmy Z. Liu, Tom G. Richardson, Philippe Sanseau, Robert A. Scott, Daniel D. Seaton, Ashwini Sharma, Adrian Cortes   +12 more
doaj   +2 more sources

Transportability of nonlocal real-world evidence and its relevance to health technology assessment: a primer [PDF]

Journal of Comparative Effectiveness Research
Real-world evidence (RWE) from outside Canada or the UK is sometimes included in submissions to health technology assessments by Canada’s Drug Agency/L’Agence des medicaments du Canada (CDAAMC) and National Institute for Health and Care Excellence when
Alind Gupta, Stephen Duffield, Cal Shephard, Eon Ting, Sanjay Popat, Winson Y Cheung, Paul Arora   +6 more
doaj   +2 more sources

R WE ready for reimbursement? A round-up of developments in real-world evidence relating to health technology assessment: part 23 [PDF]

Journal of Comparative Effectiveness Research
In this update, we explore a review on transportability methods to enable the use of cross-jurisdictional evidence when local data are limited, a review of clinical trials that use pragmatic elements and finally, we discuss a study highlighting the ...
Paul Arora, Sreeram V Ramagopalan
doaj   +2 more sources

Use of transportability methods for real-world evidence generation: a review of current applications

Journal of Comparative Effectiveness Research
Aim: To evaluate how transportability methods are currently used for real-world evidence (RWE) generation to inform good practices and support adoption and acceptance of these methods in the RWE context.
Natalie S Levy, Thomas Jemielita, Ashley Jakša   +2 more
exaly   +2 more sources

Inpatient Recovery of Function After Knee Replacement: A Longitudinal Evaluation Across Four Sequential Care Pathway Redesigns [PDF]

Learning Health Systems
Introduction Inpatient recovery of activities (IRoA) is a key outcome after total knee replacement (TKR), reflecting the patient's ability to regain independence.
Jelmer Jager, Wim vanHoutert, Wim P. Krijnen, Richard Bimmel, Nico L. U. vanMeeteren, Thomas J. Hoogeboom, Reinier P. Akkermans, Geert van derSluis   +7 more
doaj   +2 more sources

Letter to the editor regarding the article “Development of a new predictive clinico-biological score for acute appendicitis in the pediatric population” [PDF]

BMC Surgery
The recently published pediatric appendicitis score demonstrates promising discriminative performance. However, key methodological aspects—including predictor handling, possible predictor redundancy or multicollinearity, absence of calibration analysis ...
Javier Arredondo Montero
doaj   +2 more sources