Results 61 to 70 of about 5,985 (254)

Best practices for acceptability of GM crops field trials conclusions: lessons for Africa

GM Crops & Food
The ability to transfer information about the performance, safety, and environmental impacts of a genetically modified (GM) crop from confined field trials (CFTs) conducted in one location to another is increasingly gaining importance in biosafety ...
Paul Chege, Julia Njagi, John Komen, Godfrey Ngure, John Muriuki, Margaret Karembu   +5 more
doaj   +1 more source

The effects on mucociliary clearance of prednisone associated with bronchial section

Clinics, 2012
OBJECTIVE: Infections have been and remain the major cause of morbidity and mortality after lung transplantation. Because mucociliary clearance plays an important role in human defense mechanisms, the influence of drugs on the mucociliary epithelium of ...
Karina Andrighetti de Oliveira Braga, Natalia Aparecida Nepomuceno, Aristides Tadeu Correia, Fabio Biscegli Jatene, Paulo Manuel Pêgo-Fernandes   +4 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Transportability of overall survival estimates from the USA to France in patients with metastatic triple-negative breast cancer

ESMO Real World Data and Digital Oncology
Background: Metastatic triple-negative breast cancer (mTNBC) represents an aggressive breast cancer subtype with limited treatment options. The external validity of transportability for real-world evidence (RWE) applied across health care systems remains
C. Esnault, L. Simomia, G. Machuron, M. Robain, B. Adamson, V. Machuron   +5 more
doaj   +1 more source

Effects of mycophenolate sodium on mucociliary clearance using a bronchial section and anastomosis rodent model

Clinics, 2011
OBJECTIVE: To study the effects of mycophenolate sodium on mucociliary clearance. INTRODUCTION: Mycophenolate is one of the most commonly used immunosuppressive drugs in lung transplantation.
Viviane Ferreira Paes e Silva, Rogerio Pazetti, Sonia de Fatima Soto, Mariana Moreira Quinhones Siqueira, Aristides Tadeu Correia, Fabio Biscegli Jatene, Paulo Manuel Pego-Fernandes   +6 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

The Narrative Engageability Scale: A Multidimensional Trait Measure for the Propensity to Become Engaged in a Story

International Journal of Communication, 2019
This study developed a self-report measure for Narrative Engageability using 4 different data sets (N = 339, N = 514, N = 121, N = 151). Scale development started with an exploratory factor analysis, resulting in a 12-item measure with 4 distinct ...
Helena Bilandzic, Freya Sukalla, Cornelia Schnell, Matthias R. Hastall, Rick W. Busselle   +4 more
doaj  

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source